Living Related and Unrelated Donors for Kidney Transplantation A 28-Year Experience

Abstract

ObjectiveThe objective of this study was to analyze a single center's 28-year experience with 1000 living donor transplants. Summary Background DataThe number of potential renal transplant recipients far exceeds the number of cadaveric donors. For this reason, living related donors (LRDs) and, more recently, living unrelated donors (LURDs) have been used to decrease the cadaveric donor shortage. MethodsFrom November 15, 1966, until August 5, 1994, 1000 living donor transplants were performed; 906 were living related and 94 were living unrelated transplants. Results were divided into precyclosporine , era 1) and cyclosporine (1986-1994, era 11) eras. Patient and graft survivals were compared between diabetic and nondiabetic recipients, between LRDs and LURDs, and according to human leukocyte antigen (HLA) matching. Donor mortality, morbidity, and postoperative renal function were also analyzed. ResultsThe 5-, 10-, and 20-year graft survivals were 78.8%, 64.8%, and 43.4%, respectively. Patient and graft survival improved in era 11 (patient =

Two Hundred One Consecutive Living-Donor Nephrectomies

“…5,14-16 An apparent difference is the incidence of pneumothorax requiring a chest tube, which was 7% in the series of D'Alessandro et al 14 Cosimi 5 reported an incidence of 9% in his collective series, although whether all patients required chest tubes was not specified. Chest tubes for postoperative pneumothorax were required in only 1% of our patients, although radiographic evidence of an incidental or asymptomatic pneumothorax was found in an additional 10%.…”

When Disaster Strikes: Death of a Living Organ Donor

“…Yet living organ donors have died. The first living donor death that was reported in the medical literature occurred in 1970 due to a pulmonary embolus following kidney donation (2). Live kidney donation is performed routinely in the United States and over 6000 live donor nephrectomies are performed each year (3 (Table 2).…”

Pathology of Renal Transplantation

“…Similarly, a chronically failing allograft may show an apparent acute rise in serum creatinine, resulting from diminished functional reserve, and precipitated by some acute insult (John & Herzenberg, 2010). It is worth reiterating that the causes of renal allograft dysfunction vary depending on the induction protocol, maintenance immunosuppression, living vs. cadaveric organ source, and many other factors (D'Alessandro et al, 1995;Farnsworth et al, 1984;Matas et al, 2001;Mihatsch et al, 1985;Mishra et al, 2004;Ratnakar et al, 2002;Rizvi et al, 2011;Verma et al, 2007).…”