LIX Scleroma in Guatemala

Quevedo, Julio

doi:10.1177/000348944905800301

Cited by 35 publications

(12 citation statements)

References 29 publications

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“…RS is also rare in the United States, but recent reports suggest an increase in cases because of migration from endemic areas [22]. Regions with high endemicity (e.g., Guatemala [23], El Salvador [24], Mexico [25], Colombia [26], and Egypt [27]) have hundreds of reported cases. Within those countries, the endemic areas tend to remain well defined and are often quite small [17,26,28].…”

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confidence: 99%

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

et al. 2008

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Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

et al. 2008

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“…This may represent mutational resistance, a phenomenon demonstrated with the early use of streptomycin in the treatment of tuberculosis (15). Despite the in vitro demonstration of susceptibility to sulfonamide, clinical trials in the 1940s did not document the efficacy of this agent (16). In contrast, more recent studies have shown success with TMP-SMX (1, 9, 18).…”

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In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis

Perkins¹,

Hamill²,

Musher³

et al. 1992

Antimicrob Agents Chemother

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We tested in vitro the activities of streptomycin and tetracycline-antibiotics that have long been used to treat rhinoscleroma-as well as several newer oral agents by using 23 isolates of the causative organism KlebsieUla rhinosckeromatis. All isolates were inhibited by clinically achievable concentrations of trimethoprim-sulfamethoxazole, amoxicillin-clavulanate, chloramphenicol, ciprofloxacin, cephalexin, cefuroxime, and cefpodoxime.Klebsiella rhinoscleromatis causes rhinoscleroma, a chronic granulomatous infection of the upper airways. This disease occurs sporadically in the United States (3,11,19); but it is endemic in parts of Europe, Africa, Central and South America, and southern Asia, where thousands of humans may be afflicted (12). Prolonged antimicrobial treatment is required to cure rhinoscleroma. Streptomycin in combination with tetracycline has long been regarded as the standard treatment (7, 10), although rifampin (7, 8) has more recently been found to be effective either by topical application or oral ingestion. Trimethoprim-sulfamethoxazole (TMP-SMX) (1, 7) has also been recommended, but this recommendation has been made in the absence of published clinical trials. Anecdotal reports describe the efficacy of expanded-spectrum cephalosporins (3). No systematic in vitro study of the antibiotic susceptibility of K rhinoscleromatis has been described for two decades, and the efficacies of more recently available antibiotics that are administered orally have not been reported. We examined the in vitro inhibitory and bactericidal activities of antimicrobial agents that have traditionally been used to treat rhinoscleroma as well as those of some newly available ones. Since prolonged treatment is required in treating this disease, we directed our study toward orally available antimicrobial agents.Twenty

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“…It has been reported in 168 countries, mostly from Central Europe, extending into Ukraine and around the Black and Caspian Seas. [5] Regions with high endemicity (e.g., Guatemala,[6] El Salvador,[7] Mexico,[8] Colombia,[9] and Egypt[10]) have hundreds of reported cases. Rhinoscleroma is more frequent among people in the second or third decades of life, living in crowded conditions, rural areas, with poor hygienic and nutritional conditions such as iron deficiency anemia.…”

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confidence: 99%

Septal rhinoscleroma

Shoeib¹

2010

Indian J Plast Surg

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Rhinoscleroma is a chronic granulomatous condition of the nose and other structures of the upper respiratory tract. Infection by the bacterium Klebsiella rhinoscleromatis is said to be the cause. A female patient aged 45 years, presented with a past history of trauma to the nose and swelling on her nose since last 1 year. There was nasal asymmetry and internal nasal examination showed a septal swelling protruding to the right nasal cavity with hypertrophied nasal mucosa and inferior turbinate. Open tip rhinoplasty approach was used to excise the mass, which examined pathologically revealing a rhinoscleroma, fibrotic infiltrative stage.

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LIX Scleroma in Guatemala

Cited by 35 publications

References 29 publications

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

Rhinoscleroma: A French National Retrospective Study of Epidemiological and Clinical Features

In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis

Septal rhinoscleroma

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