2022
DOI: 10.1073/pnas.2201371119
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Lizards from warm and declining populations are born with extremely short telomeres

Abstract: Aging is the price to pay for acquiring and processing energy through cellular activity and life history productivity. Climate warming can exacerbate the inherent pace of aging, as illustrated by a faster erosion of protective telomere DNA sequences. This biomarker integrates individual pace of life and parental effects through the germline, but whether intra- and intergenerational telomere dynamics underlies population trends remains an open question. Here, we investigated the covariation between life history… Show more

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Cited by 30 publications
(30 citation statements)
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“…In anthropogenic habitats where the risk of adult mortality is high, selection might favor individuals investing heavily in reproduction at the expense of somatic maintenance, which could result in the deterioration of some physiological functions, thereby accelerating senescence and shortening lifespan (44). Third, stressful environmental conditions brought about by human activities could have a direct detrimental impact on organisms' physiology (e.g., accelerated telomere attrition [45], as recently reported in common lizard [Zootoca vivipara] in the context of climate warming [46]), which may intensify senescence and shorten lifespan in the long run. Irrespective of the pathway involved, we provide evidence of a close link between habitat anthropization and senescence of B. variegata, which supports the hypothesis that anthropogenic global change is a critical driver of aging in animal populations (47,48).…”
Section: Anthropogenic Habitats Are Associated With Increased Adultmentioning
confidence: 99%
“…In anthropogenic habitats where the risk of adult mortality is high, selection might favor individuals investing heavily in reproduction at the expense of somatic maintenance, which could result in the deterioration of some physiological functions, thereby accelerating senescence and shortening lifespan (44). Third, stressful environmental conditions brought about by human activities could have a direct detrimental impact on organisms' physiology (e.g., accelerated telomere attrition [45], as recently reported in common lizard [Zootoca vivipara] in the context of climate warming [46]), which may intensify senescence and shorten lifespan in the long run. Irrespective of the pathway involved, we provide evidence of a close link between habitat anthropization and senescence of B. variegata, which supports the hypothesis that anthropogenic global change is a critical driver of aging in animal populations (47,48).…”
Section: Anthropogenic Habitats Are Associated With Increased Adultmentioning
confidence: 99%
“…However, further studies on multiple populations are required to disentangle the speci c (environmental) effects shaping such population differences [87]. Contrasting intraspeci c TL dynamics have also been found in different populations of European roe deer (Capreolus capreolus) whose habitats differ in food availability [88], in great tits (Parus major) living in urban or rural environments where diet composition differs [89], in American redstarts (Setophaga ruticilla) over-wintering in different non-breeding habitat types that also vary in food availability [90], in pied ycatchers (Ficedula hypoleuca) breeding in different habitats across Europe [91], and in populations of spotted snow skinks (Niveoscincus ocellatus [92]), common lizards (Zootoca vivipara [93]) and moose (Alces alces [94]) experiencing different thermal environments.…”
Section: Discussionmentioning
confidence: 99%
“…Identifying the ecoevolutionary causes and consequences of individual variation in TL has recently become a popular topic (5). In that context, the study by Dupou e et al (6) among populations of lizards subjected to a continuum of environmental harshness pushes the field forward by shedding an exciting light on the ecological relevance of TL.…”
Section: Telomeres As a Sentinel Of Population Decline In The Context...mentioning
confidence: 99%
“…Natural populations can be placed along a gradient from stable to pseudoextinct populations. Based on the finding from Dupou e et al (6), TL can serve as a tool to detect threatened populations as soon as they start to decline. Once TL reaches a critical threshold, telomeres indicate a shift in population sustainability.…”
Section: Toward a New Generation Of Physiological Indicators Of Popul...mentioning
confidence: 99%