LL-Z1271α: An Interleukin-1β Production Inhibitor

Ichikawa, Keita; Inagaki, Taisuke; Kachi-Tonai, Hiroko; Kojima, Yasuhiro; Nakamura, Takaaki; Nishida, Hiroyuki; Ueno, Yoshinobu; Binding, Peter; Gabel, Christopher A.; Lucas, Val; McNiff, Patricia A.; Kojima, Nakao

doi:10.1006/bbrc.2001.5458

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…At a concentration of 10 −4 M, Compound 1 significantly inhibited the germination and growth development of three plant species: two monocotyledons ( Allium cepa and Hordeum vulgare ) and one dicotyledon ( Lactuca sativa ), with an inhibition rate of over 80%, which is more active than the commercial herbicide LOGRAN ® , indicating that 1 shows potential as a herbicide template and may serve as a next generation of natural agrochemicals [ 27 ]. Compound 1 displayed potent inhibitory activity to the production of IL-1β (interleukin-1β, a proinflammatory cytokine produced primarily by macrophages and monocytes in answer to various stimuli [ 28 ]) in the manner of dose-dependent application with an IC 50 value of 0.049 μM in human whole blood [ 29 , 30 ]. Compound 1 exhibited a much weaker inhibitory effect on leucine uptake than on IL-1β production which suggests that the compound’s action is not a result of general effects on protein synthesis.…”

Section: Terpenoidsmentioning

confidence: 99%

“…Compound 1 exhibited a much weaker inhibitory effect on leucine uptake than on IL-1β production which suggests that the compound’s action is not a result of general effects on protein synthesis. The inhibition mechanism of 1 is also not because of the ATP-induced release, effects on caspase-1, or a lysosomotrophic effect [ 29 ]. Further research on the target for 1 is in progress, which may identify a mechanistically new approach for the treatment of IL-1β associated diseases [ 29 ].…”

Section: Terpenoidsmentioning

confidence: 99%

“…The inhibition mechanism of 1 is also not because of the ATP-induced release, effects on caspase-1, or a lysosomotrophic effect [ 29 ]. Further research on the target for 1 is in progress, which may identify a mechanistically new approach for the treatment of IL-1β associated diseases [ 29 ].…”

Section: Terpenoidsmentioning

confidence: 99%

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Genus Acrostalagmus: A Prolific Producer of Natural Products

Shi,

Wang,

et al. 2023

Biomolecules

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Acrostalagmus is known for its ability to produce numerous bioactive natural products, making it valuable in drug development. This review provides information on the sources, distribution, chemical structure types, biosynthesis, and biological activities of the compounds isolated from the genus Acrostalagmus in the family Plectosphaerellaceae from 1969 to 2022. The results show that 50% of the compounds isolated from Acrostalagmus are new natural products, and 82% of the natural products derived from this genus are from the marine Acrostalagmus. The compounds isolated from Acrostalagmus exhibit diverse structures, with alkaloids being of particular importance, accounting for 56% of the natural products derived from this genus. Furthermore, within the alkaloid class, 61% belong to the epipolythiodioxopiperazine family, highlighting the significance of epipolythiodioxopiperazine as a key characteristic structure within Acrostalagmus. Seventy-two percent of natural products derived from Acrostalagmus display bioactivities, with 50% of the bioactive compounds exhibiting more significant or comparable activities than their positive controls. Interestingly, 89% of potent active compounds are derived from marine fungi, demonstrating their promising potential for development. These findings underscore Acrostalagmus, particularly the marine-derived genus Acrostalagmusas, a valuable source of new bioactive secondary metabolites, and emphasize the vast resource importance of the ocean.

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Section: Terpenoidsmentioning

confidence: 99%

Section: Terpenoidsmentioning

confidence: 99%

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Genus Acrostalagmus: A Prolific Producer of Natural Products

Shi,

Wang,

et al. 2023

Biomolecules

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“…The structures of these compounds were confirmed by several spectra and singlecrystal X-ray analysis. Interestingly, the scaffolds 16 and 17 are similar to dihydrobotrydial 49 and LL-Z1271α, 50 respectively.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Remarkable Potential of Zerumbone to Generate a Library with Six Natural Product-like Skeletons by Natural Material-Related Diversity-Oriented Synthesis

et al. 2020

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Diversity-oriented synthesis (DOS) is an effective strategy for the quick creation of diverse and high three-dimensional compounds from simple starting materials. The selection of a starting material is the key to constructing useful, chemically diverse compound libraries for the development of new drugs. Here, we report a novel, general, and facile strategy for the creation of diverse compounds with high structural diversity from readily available natural products, such as zerumbone, as the synthetic starting material. Zerumbone is the major component of the essential oil from wild ginger, Zingiber zerumbet Smith. It is noteworthy that zerumbone has a powerful latent reactivity, partly because of its three double bonds, two conjugated and one isolated, and a double conjugated carbonyl group in an 11-membered ring structure. In fact, zerumbone has been shown to be a successful example of natural material-related DOS (NMRDOS). We will report that zerumbone can be converted in one chemical step from four zerumbone derivatives into rare and markedly different scaffolds by transannulation.

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