The purpose of this White Paper of the EU Support Action "Visioneer" (see www.visioneer.ethz.ch) is to address the following goals: 1. Develop strategies to build up social simulation capacities. 2. Suggest ways to build up an "artificial societies" community that aims at simulating real and alternative societies by means of supercomputers, grid or cloud computing. 3. Derive proposals to establish centers for integrative systems design. 1 Introduction 1.1 Real-world challenges Since decades, if not since hundreds of years, the world has been facing a number of recurrent socioeconomic problems which are obviously hard to solve because their roots are still not well understood. This includes, in particular, the following problems: 1. Financial and economic (in)stability (government debts, taxation, and inflation/deflation; sustainability of social benefit systems; consumption and investment behavior.. .) 2. Public health (food safety; spreading of epidemics [flu, SARS, H1N1, HIV], obesity, smoking, or unhealthy diets.. .) 3. Sustainable use of resources and environment (consumption habits, travel behavior, sustainable and efficient use of energy and other resources, participation in recycling efforts, environmental protection.. .) 4. Collective social behavior and opinion dynamics (abrupt changes in consumer behavior; social contagion, extremism, hooliganism, changing values; breakdown of cooperation, trust, compliance, solidarity.. .) 5. Security and peace (organized crime, terrorism, social unrest, independence movements, conflict, war.. .) 6. Reliability of critical infrastructures, in particular of information systems (cyber risks, misuse of sensitive data, espionage, violation of privacy; data deluge, spam; education and inheritance of culture.. .