Untitled

French, Donna L.; Haglund, Bert O.; Himmelstein, Kenneth J.; Mauger, John W.

doi:10.1023/a:1016295723253

Cited by 21 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carbopol 934 gels (1%, 2% w/w) were prepared according to the previously reported method (French et al, 1995). Carbopol was added to the water portion wise with a gentle mixing.…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels

Ela

Khatib

2014

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

The rationale of the present work is to formulate and evaluate metoprolol tartrate (MT), which is a beta-1 selective adrenergic blocking agent in a new ocular gel delivery system; this is our way and method to increase its contact to the cornea, giving a longer time of drug contact to the eye and slow possible release from the preparation. Metoprolol tartrate is chosen as a candidate for gel formulation because although it has been available for a few years as ophthalmic solutions, it has not been marketed as an ocular gel yet. Two polymers; Carbopol 934 and Pluronic F127 (PF127) were used in two different concentrations in this study. Metoprolol tartrate was used in two concentrations, 0.5% and 1% (w/w). All formulations were exposed to visual examinations, pH measurement, in vitro release, rheological study and differential scanning calorimetry (DSC). Results showed that all formulations were clear, showed pH within the acceptable range suitable to be administered in the eye, and exhibited pseudoplastic flow behavior. DSC results concluded that, MT was compatible with different polymers used. In vitro release results showed that the release rate of metoprolol tartrate from gel preparations decreased as an inverse function of polymer concentration, and the release rate of the drug increased as the initial concentration increased. Intra-ocular pressure (IOP) measurements of rabbit's eye treated with 1% (w/w) metoprolol tartrate in gel formulations with different concentrations of the polymer were determined. Carbopol 934 gel formulations showed that this polymer extended the duration of pressure reducing effect of MT to more than 5hr when compared with Pluronic F127 gel formulations. The area above the curve (AAC), maximum response, time of maximum response (t max), and the duration of the drug action were also calculated.

show abstract

“…Carbopol 934 gels (1%, 2% w/w) were prepared according to the previously reported method (French et al, 1995). Carbopol was added to the water portion wise with a gentle mixing.…”

Section: Methodsmentioning

confidence: 99%

Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels

Ela

Khatib

2014

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…al. 12 Carbopol was added to the water portion wise with gentle mixing. After complete addition of the polymer and mixing, the drug solution was added.…”

Section: Preparation Of Carbopol 974p Gelmentioning

confidence: 99%

Formulation and Evaluation of Croconazol Hydrochloride Topical Gels

El-Badry

Hussein

2005

Bulletin of Pharmaceutical Sciences. Assiut

View full text Add to dashboard Cite

This study was designed to evaluate different polymers for their suitability as a vehicles for topical drug delivery systems. Croconazol hydrochloride is an azol derivative used as antimycotic agent. It was incorporated in this vehicles as a gel forms in a concentration of 1.0% w/w. Polymers used in this study are methylcellulose (MC), Tylose (Ty), Polyvinyl alcohol (PVA), Pluronic F-127 (pl. F-127), Polyethylene glycol (PEG), Carbopol 974P (Carb.) and Eudispert mv. (Eud). They were used in a suitable concentration for gel formulation. In-vitro release characteristics of the drug from different gels were carried out using dialysis membrane in phosphate buffer pH 5.2. The release data were treated with various kinetic principles to assess the relevant parameters. The general rank order of Croconazol hydrochloride release from the prepared gel were MC > Ty > pl. F-127 > PVA > Carb > Eud > PEG. The results showed that, the release of drug from the prepared gels obeyed the diffusion model (Higuchi's equation). Some kinetic parameters were calculated such as diffusion coefficient, permeability coefficient and the partition coefficient. The results indicated a direct dependence of the release rate on the diffusion coefficient. The influence of initial drug concentration (0.5, 1.0 and 2.0% w/w), and pl F-127 concentration (20, 25, 30% w/v) on the release patterns was studied. The obtained data revealed an inverse correlation between the drug release rate and the pluronic F-127 concentration and a direct correlation between the drug release rate and the initial drug concentration. The anti-fungal activity of the different gel formulations was evaluated by agar-cup plate technique using five fungal species. The results obtained indicated that, all gel formulations have good anti-fungal activities.

show abstract

Challenges and Issues in the Development of Formulations of Protein Pharmaceuticals

Shire¹

1999

Biopharmaceutical Drug Design and Development

View full text Add to dashboard Cite

Untitled

Abstract: The release rate kinetics of mesalamine and benzoic acid correlated to the measured concentration profiles. The shape of the concentration profiles is determined by the rate of growth of the Carbopol gel layer and drug diffusivity.

Cited by 21 publications

References 12 publications

Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels

Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels

Formulation and Evaluation of Croconazol Hydrochloride Topical Gels

Challenges and Issues in the Development of Formulations of Protein Pharmaceuticals

Contact Info

Product

Resources

About