LMX1B involved in the radioresistance, proliferation and migration of esophageal cancer cells

Zang, Chunbao; Zhao, Fangfang; Pu, Youguang

doi:10.1016/j.biopha.2019.109358

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…LMX1B is reported to be highly expressed and associated with poor prognosis in laryngeal squamous cell carcinoma [22] and glioma [23]. Zang et al found that LMX1B functions in proliferation, migration, and apoptosis in esophageal carcinoma while promoting radioresistance [24]. Notably, some studies have suggested that LMX1B activity plays an important role in the development and maintenance of mesencephalic dopaminergic system function in rats [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Song

et al. 2023

Preprint

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According to mounting evidence, competing endogenous RNAs (ceRNA) play a significant role in the tumorigenesis and development of cancer. Prostate cancer (PCa) is a common malignancy among men. Nevertheless, reliable indicators for the early diagnosis and prognosis of Pca are still lacking. Therefore, this study aimed to identify competing endogenous RNA networks as novel prognostic predictors of PCa. The Cancer Genome Atlas was used to download the RNA transcriptome and clinical data of 498 Pca and 52 non-Pca tissues. Differentially expressed messenger RNAs (DEmRNAs) were identified using the edgeR package. Kaplan–Meier analysis was used to evaluate the correlation with survival. TargetScan and MiRDB were used to predict potential DRD5‒targeting microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). In addition, StarBase and GEPIA2 were used to validate regulatory and prognostic relationships. DEmRNAs, target miRNAs, and lncRNAs were identified, and a ceRNA network in PCa was constructed. A total of 1,603 Pca-specific differentially expressed genes (767 upregulated and 836 downregulated) were identified. In addition, 3 hub mRNAs, 26 miRNAs,and 2 lncRNAs were identified as a result of stepwise prediction and validation from mRNA to lncRNA. Finally, C9orf170/hsa-miR-153-5p/DRD5 was identified as a prognosis-related network in PCa through further screening. In this study, we constructed a novel ceRNA network in PCa in which each component was prognosis-related.

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Section: Discussionmentioning

confidence: 99%

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Song

et al. 2023

Preprint

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“…Evidence suggested that LMX1B is widely expressed in types of human tissues, including testis, thyroid, pancreatic islets, ocular, and skeletal muscle [15,28,29]. LMX1B has been shown associated with cell proliferation, migration, apoptosis, and inflammatory cytokine production [30][31][32]. As a transcription factor, LMX1B could regulate multiple pathways and cell physiologies via mediating associated target genes [11].…”

Section: Discussionmentioning

confidence: 99%

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

Wang

et al. 2022

Mediators of Inflammation

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Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes’ survival, inflammation, and apoptosis play critical roles in OA pathogenesis. LMX1B has been shown to be involved in antiosteogenic function in early patterning of the calvaria. However, the role and mechanism of LMX1B in OA is not unknown. The present study observed that LMX1B was highly expressed in OA patients compared with normal patients. Besides, we found that IL-1β increased LMX1B mRNA and protein expression in SW1353 and C28/I2 chondrocytes. LMX1B knockdown increased IL-1β-induced cell viability and proliferation and suppressed cell apoptosis and inflammation response, including IFN-γ, TNF-α, IL-6, prostaglandin E2 (PGE2), and NO both in SW1353 and C28/I2. Furthermore, LMX1B silence inhibited MMP-3 and MMP-13 expression both in SW1353 and C28/I2 cells. Also, the activation of the NF-κB and NLRP3 signaling pathway was suppressed in LMX1B silence cells by decreasing the p-p65 and NLRP3 protein expressions. Additionally, inhibition of NF-κB by PDTC suppressed NLRP3 expression. Moreover, NLRP3 overexpression reversed the effects of LMX1B silence on chondrocytes’ survival, proliferation, apoptosis, and inflammation. Finally, we confirmed that LMX1B depletion had protective effects in OA rats in vivo.

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“…circRNA circHipk2 expression in C2C12 myoblasts is mediated by Sp1 [34], and circ-FOXP1 in hepatocellular carcinoma cells is regulated by SOX9 [9][10][11]. Therefore, we investigated the upstream regulator of circGFRA1 in PCa cells showing that circGFRA1 is regulated by LMX1B, which has previously been shown to be involved in many cancers, including ovarian, esophageal, and glioma [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Meng

2022

Journal of Immunology Research

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Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. Despite the progress in the diagnosis and treatment of PCa, patient outcomes remain poor, and novel therapeutic targets for PCa are urgently needed. Recently, circular RNAs (circRNAs) have been studied in-depth as potential biomarkers for many diseases. In this study, circRNA microarrays using four pairs of PCa tissues were utilized to show that circGFRA1 was upregulated in PCa tumor tissues. CircGFRA1 is suggested to play an oncogene role in PCa progression as the silencing of circGFRA1 inhibited the proliferation, migration, and immune escape activity of PCa cells. Furthermore, by utilizing bioinformatics analysis, RIP, RNA pull-down, and luciferase reporter assays, our results showed that LMX1B could bind to the GFRA1 promoter and regulate circGFRA1 expression in PCa cells and circGFRA1 upregulated HECTD1 expression through sponging miR-3064-5p. This novel LMX1B/circGFRA1/miR-3064-5p/HECTD1 axis identified in PCa provides new insights for developing novel therapeutic strategies for PCa.

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LMX1B involved in the radioresistance, proliferation and migration of esophageal cancer cells

Cited by 8 publications

References 23 publications

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

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