LncBIRC3-OT promotes the malignant progression of glioma by interacting with RELA to upregulate stanniocalcin-1 expression

Wang, Renjie; Li, Qi; Chu, Xiaolei; Li, Nan; Liang, Haiqian; He, Feng

doi:10.1016/j.heliyon.2023.e21777

Cited by 2 publications

(1 citation statement)

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“…According to the 2021 World Health Organization (WHO) classification of CNS tumors, histological performance and molecular characteristics play critical roles in the new glioma classification criteria [ 5 ]. Glioma development is often accompanied by molecular mutations such as IDH mutation, TERT promoter mutations, 1p/19q codeletion, and RELA fusions [ 5 , 6 , 7 , 8 , 9 , 10 ]. Schönrock et al reported that MEOX2 is a carcinogenic transcriptional regulator in GBM [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association ofRANandRANBP2Gene Polymorphisms With Glioma Susceptibility in Chinese Children

Lin,

Chen,

Tan

et al. 2024

Cancer Reports

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BackgroundGlioma is the most prevalent pediatric central nervous system malignancy. RAN, member RAS oncogene family (RAN), is a key signaling molecule that regulates the polymerization of microtubules during mitosis. RAN binding protein 2 (RANBP2) is involved in DNA replication, mitosis, metabolism, and tumorigenesis. The effects of RAN and RANBP2 gene polymorphisms on glioma susceptibility in Chinese children are currently unknown.AimsThis study aimed to evaluate the association between RAN and RANBP2 gene polymorphisms and glioma susceptibility in Chinese children.Methods and ResultsWe recruited 191 patients with glioma and 248 children without cancer for this case–control study. Polymerase chain reaction‐based TaqMan was applied to gene sequencing and typing. Logistic regression model‐calculated odds ratio and 95% confidence interval were used to verify whether the gene polymorphisms (RAN rs56109543 C>T, rs7132224 A>G, rs14035 C>T, and RANBP2 rs2462788 C>T) influence glioma susceptibility. Based on age, gender, tumor subtype, and clinical stage, stratified analyses of risk and protective genotypes were conducted. p values for mutant genotype analyses were all >0.05, indicating no significant correlation between these gene polymorphisms and glioma risk.ConclusionRAN and RANBP2 gene polymorphisms were not found to be statistically significantly associated with glioma susceptibility in Chinese children. Other potential functional gene polymorphism loci of RAN and RANBP2 will need to be evaluated in the search for novel glioma biomarkers.

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