LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Chen, Zhenzhen; Gao, Yanfeng; Yao, Lan; Liu, Yating; Huang, Lan; Yan, Zhongyi; Zhao, Wenshan; Zhu, Pingping; Weng, Haibo

doi:10.1038/s41388-018-0203-6

Cited by 64 publications

(48 citation statements)

References 41 publications

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“…According to the existing studies, WNT5A was identified as a non-canonical ligand in Wnt family, with high expression in several human malignancies including GC [44][45][46]. It is noteworthy that WNT5A could activate the β-catenin-mediated Wnt signaling pathway, thereby driving cancerous progression [47]. Furthermore, as described in previous reports, MITF was similarly linked to Wnt/β-catenin signaling pathway [48], which is considered as one of representative target genes of β-catenin [49].…”

Section: Discussionmentioning

confidence: 99%

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF

Qing-hong

et al. 2019

Bioscience Reports

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MicroRNAs (miRNAs) are reported to play critical roles in various cancers. Recently, mounting miRNAs are found to exert oncogenic or tumor inhibitory role in gastric cancer (GC), however, their potential molecular mechanism in GC remains ill-defined. Currently, we aimed to elucidate the functional and mechanistic impacts of a novel miRNA on GC cellular process. The significant down-regulation of miR-876-5p in GC cells attracted our attention. In function, we performed gain-of-function assays and found that miR-876-5p overexpression repressed proliferative, anti-apoptotic and migratory abilities and epithelial–mesenchymal transition (EMT) of GC cells. By applying bioinformatics prediction and mechanism experiments, we verified that miR-876-5p could double-bind to the 3′ untranslated regions (3′UTRs) of Wnt family member 5A (WNT5A) and melanogenesis associated transcription factor (MITF), thus regulating their mRNA and protein levels. Both WNT5A and MITF were highly expressed in GC cells. Additionally, we conducted loss-of-function assays and confirmed the oncogenic roles of WNT5A and MITF in GC. Finally, rescue assay uncovered a fact that miR-876-5p suppressed GC cell viability and migration, but induced cell apoptosis via targeting WNT5A and MITF. Taken together, we might offer a valuable evidence for miR-876-5p role in GC development.

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Section: Discussionmentioning

confidence: 99%

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF

Qing-hong

et al. 2019

Bioscience Reports

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“…For example, LncFZD6, which is overexpressed in liver cancer and liver TICs, drives liver TIC self-renewal and tumor initiation capacity. Mechanistically, lncFZD6 directly binds and recruits the BRG1 (Brahma-related Gene 1 protein)-embedded the switch/sucrose non-fermenting (SWI/SNF) complex to the FZD6 promoter, which facilitates the transcription of FZD6 via chromatin remodeling [21]. Similarly, the overexpressed lncHOXA10 recruits the nucleosome remodeling factor (NURF) chromatin remodeling complex to the HOXA10 promoter to initiate the expression of HOXA10, and ultimately promotes the self-renewal of liver TICs and the progression of HCC [22].…”

Section: Lncrnas As Novel Regulators In Hcc Metastasismentioning

confidence: 99%

“…Additionally, a divergent lncRNA of Mitogen-activated protein kinase 6 (MAPK6), called lncMAPK6, is highly expressed along with liver tumorigenesis. It interacts with and recruits RNA polymerase II to be a MAPK6 promoter, and finally activates the transcription of MAPK6 ( Figure 1B) [21].…”

Section: Lncrnas As Novel Regulators In Hcc Metastasismentioning

confidence: 99%

“…Overexpressed linc00210 in liver cancer tissues can interact with CTNNBIP1 (catenin beta interacting protein 1), thereby blocking the inhibitory role of CTNNBIP1 in Wnt/β-catenin activation and promoting the interaction of β-catenin and the TCF/LEF complex, to activate Wnt/β-catenin signaling and liver tumor progression [61]. Moreover, lncFZD6 can also affect the Wnt/β-catenin signaling pathway, and drives Wnt/β-catenin activation through lncFZD6-BRG1-FZD6, thus promoting liver TIC self-renewal [21]. Lnc-FTX also inhibits HCC metastasis and invasion by upregulating the miR-374a target genes WIF1, PTEN, and WNT5A and repressing Wnt/β-catenin signaling activity [62].…”

Section: Pathways Controlled By Lncrnas In Hcc Metastasismentioning

confidence: 99%

“…In addition, lncRNAs also mediate tumor cells that exhibit unique metabolic phenotypes, such as lncRNA TUG1 (taurine up-regulated gene 1), which exerts a master regulator to coordinate glycolysis and metastasis in HCC [71]. Furthermore, emerging findings revealed that lncRNAs can modulate the transcription of metastasis-related genes to maintain TIC self-renewal and tumor initiation capacity, such as lncSox4 [23], lncFZD6 [21], and lncHOXA10 [22]. Moreover, lncRNA HULC and MALAT1 may promote HCC metastasis via enhancing EMT and migration in the miRNAs/ZEB1 signaling [16,38].…”

Section: Role Of Lncrnas In the Multi-step Process Of Hcc Metastasismentioning

confidence: 99%

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The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

et al. 2019

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Long non-coding RNAs (lncRNAs) play multifaceted roles in modulating gene expression under both physiological and pathological processes. The dysregulation of lncRNAs has been increasingly linked with many human diseases, including a plethora of cancers. Mounting evidence indicates that lncRNAs are aberrantly expressed in hepatocellular carcinoma (HCC) and can regulate HCC progression, as well as metastasis. In this review, we summarize the recent findings on the expanding roles of lncRNAs in modulating various functions of HCC, and elaborate on how can lncRNAs impact HCC metastasis and progression via interacting with chromatin, RNA, and proteins at the epigenetic, transcriptional, and post-transcriptional levels. This mini-review also highlights the current advances regarding the signaling pathways of lncRNAs in HCC metastasis and sheds light on the possible application of lncRNAs for the prevention and treatment of HCC.

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BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma

Zhang

Wang

Zhang

et al. 2021

Cancer Communications

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Background Long non‐coding RNAs (lncRNAs) have been found to be involved in the development of many cancers. In this study, we aimed to identify the molecular mechanisms of lncRNA BAALC antisense RNA 1 (BAALC‐AS1) in regulating the malignancy of esophageal squamous cell carcinoma (ESCC). Methods The expression of BAALC‐AS1 in cancer patients was analyzed using a tissue microarray. The protein and RNA levels of BAALC‐AS1 were determined by Western blotting analysis and quantitative reverse transcription‐PCR (RT‐qPCR), respectively. The cell proliferation was determined by cell viability assays, bromodeoxyuridine incorporation, and flow cytometry. The relationships among BAALC‐AS1, RasGAPSH3 domain‐binding protein 2 (G3BP2), and c‐Myc were determined using RNA immunoprecipitation, RNA pull‐down assays, and luciferase assays. Results The expression of BAALC‐AS1 was highly up‐regulated and associated with malignant phenotypes in ESCC tissues and cell lines. In vivo and in vitro assays showed that BAALC‐AS1 promoted ESCC cell proliferation, migration, and invasion. BAALC‐AS1 directly interacted with G3BP2, and thereby inhibited the degradation of c‐Myc RNA 3'‐UTR by G3BP2, thus leading to the accumulation of c‐Myc expression. Additionally, c‐Myc acted as a transcription factor that can induce the expression of BAALC‐AS1 by directly binding to its promoter region. Conclusions BAALC‐AS1/G3BP2/c‐Myc feedback loop plays a critical role in the development of ESCC, which might provide a novel therapeutic target and facilitate the development of new therapeutic strategies for the treatment of ESCC.

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LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Cited by 64 publications

References 41 publications

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma

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