LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p/FOXF2 signaling pathway

Wang, Aihong; Jin, Canhui; Li, Hongyu; Qin, Qiaohong; Li, Lei

doi:10.1016/j.ijbiomac.2018.09.179

Cited by 70 publications

(55 citation statements)

References 18 publications

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“…We reviewed the relevant references. 24 In the ADAMTS9-AS2 related regulatory network ( Figure 3A), ADAMTS9-AS2 interacts with 75 mRNAs and 12 miRNAs. In gliomas, ADAMTS9-AS2 acts as a novel tumor suppressor that inhibits glioma cell metastasis.…”

Section: Relationship Between Lncrnamentioning

confidence: 99%

“…23 In ovarian cancer, ADAMTS9-AS2 affects the progression of ovarian cancer by targeting the miR-182-5p/FOXF2 signaling pathway. 24 In the ADAMTS9-AS2 related regulatory network ( Figure 3A), ADAMTS9-AS2 interacts with 75 mRNAs and 12 miRNAs. Functional enrichment analysis was performed on mRNAs linked to ADAMTS9-AS2.…”

Section: Adamts9-as2 Related Regulatory Network and Gastric Cancermentioning

confidence: 99%

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Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Wang

Ding

et al. 2019

J of Cellular Biochemistry

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The oncogenesis and progression of gastric cancer are closely correlated with the complex regulatory relationships among messenger RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA). After constructing the gastric cancer lncRNA‐miRNA‐mRNA regulatory network, we analyzed the network topology properties and found that lncRNA ADAMTS9‐AS2 and C20orf166‐AS1 and miRNA hsa‐mir‐204 are key nodes. Further functional enrichment analysis and survival analysis were performed on these key nodes and the RNAs interacting with them. We found that CHRM2, ANGPT2, and COL1A1 interacting with ADAMTS9‐AS2 are enriched in the PI3K‐Akt signaling pathway, and low expression of the ADAMTS9‐AS2 is closely related to the prognosis of patients. Abnormal expression of CACNA1H, FLNA, and FLNC interacting with lncRNA C20orf166‐AS1 is associated with MAPK signaling pathway in gastric cancer. In addition, the downregulated miRNA hsa‐mir‐204 promotes invasion and proliferation of gastric cancer cells by regulating the abnormal expression of mRNAs (CHRDL1 and NPTX1) and lncRNAs (ADAMTS9‐AS2, NKX2‐1‐AS1, TLR8‐AS1, and VCAN‐AS1). This study systematically analyzed the lncRNA‐miRNA‐mRNA regulatory network of gastric cancer, which not only has a new understanding of the pathogenesis of gastric cancer, but also provides new insights for the early diagnosis and treatment of gastric cancer.

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Section: Relationship Between Lncrnamentioning

confidence: 99%

Section: Adamts9-as2 Related Regulatory Network and Gastric Cancermentioning

confidence: 99%

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Wang

Ding

et al. 2019

J of Cellular Biochemistry

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“…LncRNA ADAMTS9‐AS2 participates in the development of various tumours. Previous researches have reported that down‐regulation of ADAMTS9‐AS2 was in glioma, colorectal cancer, ovarian cancer and clear cell renal cell carcinoma . In addition, other reports revealed that ADAMTS9‐AS2 inhibited the tumour progression by the miR‐223‐3p/TGFBR3 axis in lung cancer .…”

Section: Discussionmentioning

confidence: 97%

LncRNA ADAMTS9‐AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP

Wang

Tang

et al. 2020

J Cellular Molecular Medi

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| INTRODUC TI ONGastric cancer (GC) is one of the most common groups of malignancies in the world. There are one million new cases worldwide each year, mainly in developing countries, especially in China. The incidence of GC is second in various cancers in China. 1 As in recent decades in China for GC prevention and control efforts, the effect of treatment for GC has occurred great changes, but the survival rate remains poor. 2The specific mechanism of the occurrence and development of GC are still not entirely clear. In these years, many studies have confirmed that Abstract Nowadays, research on CSCs is still in an initial stage, and there are few studies reporting the successful isolation and identification of CSCs. In the present study, we attempted to isolate CSCs through cultivating the cell line MKN45 in defined serum-free medium and study the expression of stem cell markers or related proteins (Oct3/4, Sox2, Nanog and CD44) in CSCs. Moreover, immunofluorescence staining was performed to validate the stem cell markers of spheroid body-forming cells.Further experiments were used to evaluate the SPOP expression in tumorsphere cells. In addition, ADAMTS9-AS2 is a lncRNA that contributes to the genesis and development of many cancers, including gastric cancer (GC). We found ADAMTS9-AS2 functioned as an anti-oncogene and positively correlated with the expression of SPOP in GC tissues by combining bioinformatics analyses. Furthermore, we reported that ADAMTS9-AS2 regulated the expression of SPOP in GC cells and tumorsphere cells to inhibit GC progression. Together, our results demonstrated that SPOP and ADAMTS9-AS2 can be potential targets for GC treatment. K E Y W O R D S ADAMTS9-AS2, cancer stem cells, gastric cancer, Speckle-type POZ protein, tumorsphere S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Wang F, Tang C, Xu D, et al. LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.

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“…LncRNA TP73‐AS1 aggravates gastric cancer cell growth and metastasis via targeting miR‐194‐5p/SDAD1 axis (Ding, et al, 2018). LncRNA ADAMTS9‐AS2 sponges miR‐182‐5p to modulate ovarian cancer progression via upregulation of FOXF2 (A. Wang, et al, 2018). LINC00667 has been certified to induce renal tubular epithelial cell proliferation and ameliorate renal fibrosis in chronic renal failure (Chen et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

LINC00667 promotes Wilms’ tumor metastasis and stemness by sponging miR‐200b/c/429 family to regulate IKK‐β

Liu

Chen

Huang

et al. 2020

Cell Biology International

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Wilms' tumor, also known as nephroblastoma, is a kind of pediatric renal cancer. Previous studies have indicated that microRNAs (miRNAs) regulate various cancers progression. However, whether miR-200 family regulated Wilms' tumor progression remains to be elucidated. In our study, miR-200b/c/429 expression was downregulated in Wilms' tumor tissue samples from 25 patients. And data from three independent analyses of quantitative real-time polymerase chain reaction revealed that the expression of miR-200b/c/429 was downregulated in Wilms' tumor cell lines. Functionally, Cell counting kit-8 assay revealed that cell viability was reduced by overexpressing miR-200b/c/429. Transwell assay manifested that cell migration and invasion was hindered by miR-200b/c/429 overexpression. Sphere-forming and western blot assays demonstrated that miR-200b/c/429 overexpression suppressed the sphere formation ability. Mechanically, nuclear factor-κB (NF-κB) pathway was confirmed to be associated with Wilms' tumor progression; miR-200b/c/429 overexpression inactivated NF-κB pathway as miR-200b/c/429 was identified to target IκB kinase β (IKK-β), an NF-κB pathway-related gene. Moreover, miR-200b/c/429 was sponged by LINC00667 in Wilms' tumor cells. LINC00667 competitively bound with miR-200b/c/429 to regulate IKK-β expression and then activated NF-κB pathway in Wilms' tumor. Subsequently, rescue assays illustrated that silencing of IKK-β could reverse the effect of miR-200b/c/429 inhibition on the progression of sh-LINC00667-transfected Wilms' tumor cells. In summary, LINC00667 promoted Wilms' tumor progression by sponging miR-200b/c/429 family to regulate IKK-β.

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LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p/FOXF2 signaling pathway

Cited by 70 publications

References 18 publications

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

LncRNA ADAMTS9‐AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP

LINC00667 promotes Wilms’ tumor metastasis and stemness by sponging miR‐200b/c/429 family to regulate IKK‐β

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