LncRNA ANRIL promotes cell proliferation, migration and invasion during acute myeloid leukemia pathogenesis via negatively regulating miR-34a

Wang, Chenghong; Li, Qianyuan; Nie, Lu; Ma, Jie; Yao, Chenjiao; Chen, Fangping

doi:10.1016/j.biocel.2019.105666

Cited by 31 publications

(34 citation statements)

References 32 publications

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“…In acute myeloid leukemia (AML), ANRIL is up-regulated in patients at diagnosis and down-regulated in patients with complete remission; it is proved to modulate the glucose metabolism related pathway of AdipoR1/AMPK/SIRT1 to promote AML cell survival [ 43 ]. ANRIL also sponges miR-34a to up-regulate HDAC1, and in turn mediate the epigenetic suppression of ASPP2, which contributes to the proliferation, migration and invasion of AML cells [ 44 ]. In this study, it was demonstrated that compared with healthy cases, ANRIL was significantly highly expressed in the bone marrow tissues of T-ALL patients.…”

Section: Discussionmentioning

confidence: 99%

LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia

Gao

Zhao

et al. 2020

Cancer Cell Int

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Background Antisense non-coding RNA in the INK4 locus (ANRIL) is of great importance in cell biological behaviors, and ANRIL functions in many kinds of cancers including leukemia. However, the mechanism of ANRIL in the progression of T-cell acute lymphoblastic leukemia (T-ALL) has not been clarified clearly. Methods qRT-PCR was performed to detect ANRIL expression in T-ALL samples. T-ALL cell lines (MOLT4, CCRF-CEM and KOPT-K1) were used as the cell models. The function of ANRIL on T-ALL cells was investigated by CCK-8 assays, Transwell assays, and apoptosis experiments in vitro. qRT-PCR, Western blot, luciferase reporter assay and RIP assay were used to confirm the interactions between ANRIL and miR-7-5p, miR-7-5p and its target gene transcription factor 4 (TCF4). Results ANRIL was significantly up-regulated in T-ALL samples. Its knockdown markedly inhibited viability, migration and invasion of T-ALL cells, but its overexpression exerted the opposite effects. TCF4 was proved to be a target gene of miR-7-5p. ANRIL down-regulated miR-7-5p via sponging it and in turn up-regulated TCF4. Conclusions LncRNA ANRIL can modulate malignant phenotypes of T-ALL cells, possibly by regulating miR-7-5p/TCF4 axis, and it serves as a potential therapeutic target for T-ALL.

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Section: Discussionmentioning

confidence: 99%

LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia

Gao

Zhao

et al. 2020

Cancer Cell Int

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“…In gastric cancer, lncRNA ANRIL knockdown was observed to inhibit cell viability, migration and invasion, and facilitate cell apoptosis by miR-99a-mediated downregulation of B-lymphoma Moloney murine leukemiavirus insertion region 1 (23). Regarding hematological malignancies, lncRNA ANRIL knockdown was indicated to suppress cell proliferation, migration and invasion, and facilitate cell apoptosis in AML (12). However, the clinical implications of lncRNA ANRIL in patients with AML have remained to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) is located in the chromosome 9p21 region and is identified in patients with familial melanoma with germline deletion in the INK4B-ARF-INK4A gene cluster (5,6). Several studies have reported that lncRNA ANRIL is essential for the pathogenesis of various cancers (7)(8)(9)(10)(11)(12)(13). For instance, lncRNA ANRIL enhances the growth, invasion and migration of cancer cells in laryngeal squamous cell and hepatocellular carcinoma (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, lncRNA ANRIL enhances the growth, invasion and migration of cancer cells in laryngeal squamous cell and hepatocellular carcinoma (7,8). In AML, lncRNA ANRIL facilitates cell proliferation, migration and invasion, and represses cell apoptosis by modulating the expression of microRNA (miR)-34a, histone deacetylase 1 and ASPP2 (12). Furthermore, lncRNA ANRIL enhances malignant cell survival via a glucose metabolism pathway involving adiponectin receptor (AdipoR1)/AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1) in AML (13).…”

Section: Introductionmentioning

confidence: 99%

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Long non‑coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemia

et al. 2020

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The present study explored the association of long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) with the development of acute myeloid leukemia (AML) clinical features and prognosis of patients with AML. Bone marrow mononuclear cells (BMMCs) were obtained from 178 patients with de novo AML prior to initial therapy and from 30 healthy donors. The expression of lncRNA ANRIL in BMMCs was detected by reverse transcription-quantitative PCR. Complete remission (CR) was assessed after induction therapy. Event-free survival (EFS) and overall survival (OS) were evaluated during the follow-up. The levels of lncRNA ANRIL were increased in patients with AML compared with those in healthy donors and were capable of distinguishing patients with AML from healthy donors (area under the curve, 0.886; 95% CI, 0.820-0.952). Furthermore, lncRNA ANRIL was associated with an increased occurrence internal tandem duplications in the FMS-like tyrosine kinase 3, decreased occurrence inv(16) or t(16;6), intermediate-risk and poor-risk stratification while no association of lncRNA ANRIL was identified with French-American-British classification, cytogenetics, isolated biallelic CCAAT/enhancer-binding protein α mutation and nucleophosmin 1 mutation in patients with AML. Furthermore, lncRNA ANRIL was significantly associated with a lower CR rate. In addition, EFS and OS were shorter in patients with high expression of lncRNA ANRIL compared with those in patients with low expression of lncRNA ANRIL. Multivariate Cox regression analyses revealed that high expression of lncRNA ANRIL, poor-risk stratification and white blood cells (>10.0x10 9 cells/l) were independent prognostic factors for shorter EFS, while high expression of lncRNA ANRIL and poorer risk stratification were independent prognostic factors for shorter OS. The present results suggested that lncRNA ANRIL has clinical relevance as a biomarker for assisting diagnosis treatment decisions and prognosis prediction and the identification of potential drug target for AML.

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“…LncRNA ANRIL-miRNA-mRNA: The lncRNA ANRIL is located on chromosome 9p21 and plays an oncogenic role in tumorigenesis[ 84 ]. ANRIL functions as a ceRNA to sponge miRNAs, thereby regulating gene expression in HCC.…”

Section: Role Of Lncrnas As Cernas In Hccmentioning

confidence: 99%

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

Niu¹,

Wang²,

Dong³

et al. 2020

WJG

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Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncoding RNAs (ncRNAs) that occupy over 90% of the human genome, and their main function is to directly or indirectly regulate messenger RNA (mRNA) expression and participate in the tumorigenesis and progression of malignances. In particular, some lncRNAs can interact with miRNAs as competing endogenous RNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNA molecules are interrelated and coordinate to form a dynamic lncRNA-mediated ceRNA regulatory network. Mounting evidence has revealed that lncRNAs that act as ceRNAs are closely related to tumorigenesis. To date, numerous studies have established many different regulatory networks in hepatocellular carcinoma (HCC), and perturbations in these ceRNA interactions may result in the initiation and progression of HCC. Herein, we emphasize recent advances concerning the biological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating the molecular mechanism underlying these HCC-related RNA molecules and providing novel insights into the diagnosis and treatment of HCC.

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LncRNA ANRIL promotes cell proliferation, migration and invasion during acute myeloid leukemia pathogenesis via negatively regulating miR-34a

Cited by 31 publications

References 32 publications

LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia

LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia

Long non‑coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemia

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

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