LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis

Wang, Chunlei; Tao, Zhen; Yang, Lin; Na, Xinyu; Qu, Yanlong

doi:10.1007/s11033-022-07364-7

Cited by 5 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Wang et al demonstrated that leptin reduced the acetylation of the p65 subunit in a SIRT1-dependent manner, thereby decreasing the transcriptional activity of NF-κB, and downregulating BACE1, which is mediated by NF-κB and reduces amyloid-β genesis [ 97 ]. It has also been reported that BACE1 is involved in the proliferation, migration, and invasion of osteosarcoma via the miR-762/SOX7 axis and in the invasion and metastasis of hepatocellular carcinoma via the miR-377-3p/CELF1 axis [ 98 , 99 ].…”

Section: The Mechanism By Which M1- and M2-polarized Macrophages Prom...mentioning

confidence: 99%

The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets

Ren,

Xu,

Ren

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Glioma is the most common and malignant tumor of the central nervous system. Glioblastoma (GBM) is the most aggressive glioma, with a poor prognosis and no effective treatment because of its high invasiveness, metabolic rate, and heterogeneity. The tumor microenvironment (TME) contains many tumor-associated macrophages (TAMs), which play a critical role in tumor proliferation, invasion, metastasis, and angiogenesis and indirectly promote an immunosuppressive microenvironment. TAM is divided into tumor-suppressive M1-like (classic activation of macrophages) and tumor-supportive M2-like (alternatively activated macrophages) polarized cells. TAMs exhibit an M1-like phenotype in the initial stages of tumor progression, and along with the promotion of lysing tumors and the functions of T cells and NK cells, tumor growth is suppressed, and they rapidly transform into M2-like polarized macrophages, which promote tumor progression. In this review, we discuss the mechanism by which M1- and M2-polarized macrophages promote or inhibit the growth of glioblastoma and indicate the future directions for treatment.

show abstract

Section: The Mechanism By Which M1- and M2-polarized Macrophages Prom...mentioning

confidence: 99%

The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets

Ren,

Xu,

Ren

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…In recent years, with intensifying research, many lncRNAs have been suggested to be involved in the regulation of osteosarcoma. lncRNA DARS-AS1 promotes the progression of osteosarcoma by regulating miR-532-3p/CCR7 [ 36 ]; lncRNA BACE1-AS regulates the proliferation, migration, and invasion of osteosarcoma cells through the miR-762/SOX7 axis [ 37 ]; lncRNA SNHG1 promotes osteosarcoma progression by upregulating S100A6 through miR-493-5p [ 38 ]. Some studies have shown that lncRNAs may provide clinical guidance for the treatment of osteosarcoma in the future.…”

Section: Discussionmentioning

confidence: 99%

The Cuproptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Tumour Immune Analysis in Osteosarcoma

Jiang

Chu

Lai³

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Background. Cuprotopsis is a type of programmed cell death discovered in recent years. Long noncoding RNAs (lncRNAs) play an important regulatory role in programmed cell death. The effect of cuproptosis-related lncRNAs on osteosarcoma is unknown. Our work, based on cuproptosis-related lncRNAs, proposes a gene signature to assess the prognosis of patients with osteosarcoma. Methods. Osteosarcoma gene expression data from The Cancer Genome Atlas (TCGA), clinical features of osteosarcoma and RNA sequencing data of normal adipose tissue were obtained from the UCSC Xena database. A cuproptosis-related lncRNA risk model was established to calculate the risk score. At the same time, cluster analysis, clinicopathological analysis, functional enrichment analysis, and prediction of compounds with potential therapeutic value were evaluated. We analyzed whether there was a correlation between the risk score and tumour immunity. RT-qPCR was used to verify the expression level of lncRNA. Results. Nine lncRNAs (AC124798.1, AC006033.2, AL450344.2, AL512625.2, LINC01060, LINC00837, AC004943.2, AC064836.3, and AC100821.2) were identified to create a risk model and indicate the prognosis of patients with osteosarcoma. The high-risk group had a worse prognosis than the low-risk group. Analysis of clinicopathological features, principal component analysis, receiver operating characteristic curve, c-index curve, and comparative analysis of models proved that the model is reliable. Functional enrichment analysis suggests that the risk score may correlate with cell energy metabolism and tumour-related biological function. Three potentially therapeutic compounds have been predicted. These analyses may be beneficial to the treatment of osteosarcoma in the future. RT-qPCR verified the expression level of three lncRNA (LINC01060, NKILA, and SNHG8). Conclusions. Cuproptosis-related lncRNAs have a strong relationship with osteosarcoma patients. Nine lncRNA models can effectively forecast the prognosis of osteosarcoma and may play a significant role in the individualized treatment of osteosarcoma patients in the future.

show abstract

Comprehensive review for non-coding RNAs: From mechanisms to therapeutic applications

Zhang,

Zhan,

Jiang

et al. 2024

Biochemical Pharmacology

View full text Add to dashboard Cite

LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis

Cited by 5 publications

References 27 publications

The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets

The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets

The Cuproptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Tumour Immune Analysis in Osteosarcoma

Comprehensive review for non-coding RNAs: From mechanisms to therapeutic applications

Contact Info

Product

Resources

About