LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1

Jingmei Cao,; Qing Zhao,; Qing Jia,; Yiming Li,

doi:10.14715/cmb/2023.69.7.29

Cell Mol Biol (Noisy-le-grand)

2023

DOI: 10.14715/cmb/2023.69.7.29

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LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1

Jingmei Cao,

Qing Zhao,

Qing Jia

et al.

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2024

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Cited by 2 publications

References 36 publications

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Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

Kazmi,

Altamimi,

Afzal

et al. 2024

Pathology - Research and Practice

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Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

Kazmi,

Altamimi,

Afzal

et al. 2024

Pathology - Research and Practice

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MiR-145-5p regulates granulosa cell proliferation by targeting the <i>SET</i> gene in KGN cells

LINGLING,

QINGXING,

JIANBO

et al. 2024

J. Reprod. Dev.

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MiR-145-5p has been implicated in the development and progression of various disorders, and it is primarily recognized as a tumor suppressor in numerous cancers types. Its expression has been reported to decrease in the granulosa cells of patients with polycystic ovarian syndrome (PCOS). This study aimed to investigate whether miR-145-5p plays a role in granulosa cell proliferation and to shed light on the underlying pathological mechanisms of follicular development in patients with PCOS. Follicular fluid samples were collected from patients with PCOS and healthy individuals. The Cell Counting Kit-8 and bromodeoxyuridine assays were performed to assess KGN cell proliferation. The expression of miR-145-5p was significantly decreased in PCOS granulosa cells than in control cells, whereas the expression of SET was increased. Furthermore, miR-145-5p suppressed the proliferation of KGN cells. SET was identified as a direct target of miR-145-5p. Additionally, SET promoted the proliferation of KGN cells, and knockdown of SET counteracted the effect of the miR-145-5p inhibitor. Therefore, miR-145-5p regulates granulosa cell proliferation by targeting the SET in KGN cells; this process may be a potential pathological pathway that contributes to follicular developmental disorders in PCOS.

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LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1

Cited by 2 publications

References 36 publications

Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

MiR-145-5p regulates granulosa cell proliferation by targeting the <i>SET</i> gene in KGN cells

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