LncRNA CRNDE Deteriorates Delayed Encephalopathy After Acute Carbon Monoxide Poisoning to Inactivate AKT/GSK3β/β-catenin Pathway via miR-212-5p

Liu, Zuolong; Bian, Miao; Pang, Li

doi:10.1007/s12640-022-00518-2

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…21 CRNDE overexpression accelerates histopathological injury and apoptosis in the hippocampus. 13 In this investigation, the ISO led to the overexpression of CRNDE and elevated NSS levels in rats and the inhibition of CRNDE suppressed the increased NSS exerted by ISO, indicating ISO might contribute to the alternation of CRNDE and CRNDE could mediate cognitive and learning ability. Morris water maze test is a classical route to test the spatial cognition and memory ability of animals.…”

Section: Discussionmentioning

confidence: 55%

“…The same target correlations were verified in acute myeloid leukemia and delayed encephalopathy after poisoning. 13,26 miR-212-5p exerts a preventive role in ISO-steered cognitive lesion by suppressing neuroinflammation, punctuating its significance on learning ability. 27 MiR-212 ameliorates neural damage in Parkinson's disease, manifesting the neuroprotective roles of miR-212-5p.…”

Section: Discussionmentioning

confidence: 99%

“…In models of acute CO poisoning, CRNDE can improve the damage to the hippocampus and neurological function, indicating CRNDE is not conducive to the repair of nerve injury. 13 Nevertheless, the mechanisms underlying CRNDE and ISO-damaged nerve function are vague.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA colorectal neoplasia differentially expressed exacerbates the impairments in learning and memory induced by isoflurane

2022

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Background This observation aimed to investigate the effect of colorectal neoplasia differentially expressed (CRNDE) targeted miR-212-5p on cognitive impairment induced by isoflurane (ISO) anesthesia in rats. Methods The cognitive function of rats was measured by Morris water maze test. QRT-PCR detection of CRNDE and miR-212-5p expression levels in rats in each group. Double luciferase was used to verify the targeting relationship between miR-212-5p and CRNDE, and commercial kits were used to detect the level of inflammatory cytokines in hippocampus. Results The concentration of CRNDE was enhanced in rats treated by ISO anesthetic. The neurological severity score was elevated, the escape latency of rats was prolonged, the stay time in the quadrant of the platform, and the number of times crossing the platform decreased in the ISO group. The above indexes of rats in ISO + si-CRNDE were improved. MiR-212-5p is a mediator in the management of CRNDE on cognition and inflammation. Conclusion CRNDE led to the deterioration of impairment on cognition induced by ISO through suppressing miR-212-5p expression and promoting neuroinflammation.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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LncRNA colorectal neoplasia differentially expressed exacerbates the impairments in learning and memory induced by isoflurane

2022

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“…It was analogous to the discoveries of Liu et al and Lu et al that when the neuronal cells in the hippocampus of mice were damaged or even apoptotic, the number of Nissl bodies was greatly decreased, and the mice might suffer from reduced memory or cognitive impairment. 30,34 Such results indicated that ISPH was able to assist in memory improvement in mice by increasing the number of Nissl bodies.…”

Section: Effect Of Enzymatic Hydrolysis Of Isp On Body Weight and Bod...mentioning

confidence: 87%

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

Ding,

Huang,

Yang

et al. 2023

J. Agric. Food Chem.

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“…Tumour exosomes promote Th17 cell differentiation in colorectal cancer by expressing the CRNDE-h lncRNA [24]. The lncRNA CRNDE has also been shown to delay the encephalopathy worsening after carbon monoxide poisoning [25]. In addition, the same lncRNA reduced the chemical resistance of gastric cancer through SRSF6regulated PICALM variable splicing [26].…”

Section: Introductionmentioning

confidence: 99%

lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs

Yuan

Wasti

et al. 2023

Oxidative Medicine and Cellular Longevity

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Background. Asthma treatment is difficult due to disease heterogeneity and comorbidities. In addition, the development of drugs targeting the underlying mechanisms of asthma remains slow. We planned to identify the most upregulated differentially expressed long noncoding RNA in asthma to explore its regulatory patterns and pathways in asthma. Methods. We sensitized mice using a mixture of ovalbumin, house dust mites, and lipopolysaccharide to establish an asthma mouse model. We also sensitized asthma cells with TGF-β1 in an in vitro model. We performed a microarray analysis to identify the lncRNA with the differential expression level in model mice. We applied hematoxylin and eosin and Masson’s trichrome stainings to mouse tissues to quantify the tissue damage extent. Next, we assess the levels of lncRNA CRNDE, miR-29a-3p, TGF-β1, MCL-1, E-cadherin, vimentin, and snail. We counted the percentages of Th17 cells using flow cytometry. Finally, we performed a dual-luciferase reporter assay to assess the association between lncRNA CRNDE and miR-29a-3p. Results. We successfully established asthma mouse/cell models and selected the lncRNA CRNDE for our study. Transfection of si-CRNDE reduced the degree of injury and inflammation in the mouse model and reversed the TGF-β1-induced epithelial-mesenchymal transition (EMT) in the cell model. Moreover, the E-cadherin level was upregulated, and the levels of IL-17A, vimentin, snail, and α-SMA were downregulated. We also discovered that lncRNA CRNDE negatively regulated miR-29a-3p and that this one in turn inhibited MCL-1 in mice. After lncRNA CRNDE expression downregulation, the level of miR-29a-3p was increased, and we detected reduced levels of MCL-1 and EMTs. Conclusions. lncRNA CRNDE expression downregulation led to reduced inflammation and reduced lung damage in mice with induced asthma, it inhibited the EMTs of lung epithelial cells via the miR-29a-3p/MCL-1 pathway, and it reduced the levels of Th17/IL-17A cells to reduce asthma signs.

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LncRNA CRNDE Deteriorates Delayed Encephalopathy After Acute Carbon Monoxide Poisoning to Inactivate AKT/GSK3β/β-catenin Pathway via miR-212-5p

Cited by 6 publications

References 34 publications

LncRNA colorectal neoplasia differentially expressed exacerbates the impairments in learning and memory induced by isoflurane

LncRNA colorectal neoplasia differentially expressed exacerbates the impairments in learning and memory induced by isoflurane

Dual Action of Reduced Allergenicity and Improved Memory of Instant Soybean Powder Hydrolysates

lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs

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