LncRNA DANCR Promotes Lung Cancer by Sequestering miR-216a

Zhen, Qiang; Gao, Lina; Wang, Renfeng; Chu, Weiwei; Zhang, Yaxiao; Zhao, Xiaojie; Lv, Baolei; Liu, Jiabao

doi:10.1177/1073274818769849

Cited by 102 publications

(92 citation statements)

References 25 publications

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“…Recently, many studies have reported that lnc‐DANCR plays an important role in esophageal cancer, glioma, osteosarcoma, colorectal cancer, cervical cancer, and so on. Recently, Liang et al reported that lnc‐DANCR promoted cervical cancer progression by upregulating ROCK1 through sponging miR‐335‐5p . In present study, we showed that lnc‐DANCR functions as a ceRNA of miR‐665 to regulate CC progression.…”

Section: Discussionsupporting

confidence: 64%

DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway

et al. 2019

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Emerging evidence has indicated that microRNAs (miRNAs) play an important role in cervical cancer (CC). However, the role of miRNA (miR)‐665 in cervical cancer remains unclear. The aim of the present study was to investigate the potential functions of miR‐665 in CC and to identify the underlying mechanisms of action. Herein, we show that miR‐665 was downregulated in CC tissues and cell lines, which is negatively correlated with tumor size, distant metastasis, advanced TNM stage and poor prognosis. Functionally, miR‐665 inhibited cell proliferation, migration and invasion and resistance of cisplatin for CC cells, as well as tumor growth. We validated that transforming growth factor beta receptor 1 (TGFBR1) was a direct target of miR‐665 and mediated the ERK/SMAD pathway. In addition, we identified miR‐665 as the competing endogenous RNA for long noncoding (lnc)‐DANCR. These observations suggested that lnc‐DANCR‐mediated miR‐665 downregulation regulates the malignant phenotype of CC cells by targeting TGFBR1 through the ERK/SMAD pathway, which may present a pathway for novel therapeutic stratagems for CC therapy.

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Section: Discussionsupporting

confidence: 64%

DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway

et al. 2019

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“…Wang et al reported that DANCR promoted the proliferation, migration and invasion of NSCLC cell lines, SPC-A1 and H1299, via regulation of the tumor suppressor miR-758-3p (37). Zhen et al demonstrated that ectopic DANCR expression induced the proliferation and colony formation of lung cancer cells, whereas DANCR silencing promoted the opposing effect (38). In the present study, it was demonstrated that DANCR was overexpressed in LAD tissue specimens and in LAD cell lines compared with para-tumor tissue and a normal lung cell line, respectively.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells

Jiang

2018

Oncol Rep

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Long non-coding RNAs (lncRNAs) have been reported to be key regulators in various types of cancer, including lung adenocarcinoma (LAD). The roles of the lncRNA differentiation antagonizing non-protein coding RNA (DANCR) and high mobility group AT-hook 2 (HMGA2) in LAD remain unclear. In the present study, it was revealed that the lncRNA DANCR was upregulated in LAD tissue and cell lines, compared with para-tumor tissue and a normal lung cell line. Additionally, elevated DANCR expression was associated with poor prognosis in the patients with LAD. Functionally, the study revealed that knockdown of DANCR inhibited invasion and HMGA2 expression in the LAD cell lines, SPCA1 and A549. Furthermore, HMGA2 was overexpressed in LAD tissue and in SPCA1 and A549 cells, compared with para-tumor tissue and a normal lung cell line. Inhibition of HMGA2 suppressed the invasive ability of SPCA1 and A549 cells, and DANCR promoted the invasive ability via regulation of HMGA2 in SPCA1 and A549 cells. The findings of the present study revealed that DANCR promoted the invasion of LAD cells by positively regulating HMGA2. Thus, a DANCR/HMGA2 axis may be a novel potential target in the molecular treatment of LAD.

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“…The DANCR overexpression promoted cell proliferation and colony formation in vitro , and DANCR interference effectively suppressed lung cancer progression both in vitro and in vivo . They found that the miR-216a level in cancer cells was negatively correlated with DANCR expression 34 . Lu et al demonstrated that DANCR was up-regulated in lung adenocarcinoma and that DANCR knockdown inhibited tumor cell proliferation, migration and invasion and restored cell apoptosis rescued.…”

Section: Dancr In Various Cancersmentioning

confidence: 99%

The functional roles of long noncoding RNA DANCR in Human Cancers

Pan¹,

Xiao²,

Zhao³

et al. 2020

J. Cancer

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Long noncoding RNAs (lncRNAs) have been wildly explored in various cellular processes and their aberrant expression could lead to tumorigenesis, development and progression. Differentiation antagonizing non-protein coding RNA (DANCR), a well-known lncRNA that is aberrant expression in various tumors, including hepatocellular carcinoma, gastric cancer, colorectal cancer, breast cancer, lung cancer and glioma and so on, in which it functions as oncogene mainly, contributing to cancer development and progression. High expressed DANCR is correlated with poor prognosis. In the present review, we summarize recent progression concerning the role, potential clinical utilities and underlying molecular mechanisms of DANCR related to occurrence and development of multiple cancers.

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LncRNA DANCR Promotes Lung Cancer by Sequestering miR-216a

Cited by 102 publications

References 25 publications

DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway

DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway

Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells

The functional roles of long noncoding RNA DANCR in Human Cancers

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