LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p

Kong, Ling‐Bin; Zhang, Chengyan

doi:10.1186/s12935-020-01452-z

Cited by 25 publications

(23 citation statements)

References 39 publications

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“… 22 LncRNA DLX6-AS1 is the decoy for miR-195-5p to aggravate ovarian cancer progression. 23 Additionally, lncRNA UCA1 sponges miR-138 to upregulate CCR7 expression and enhance tongue squamous cell carcinoma development. 24 ELFN1-AS1 was also found to sponge miR-497 and miR-183.…”

Section: Discussionmentioning

confidence: 99%

LncRNA ELFN1-AS1 Promotes Retinoblastoma Growth and Invasion via Regulating miR-4270/SBK1 Axis

Feng¹,

Zhu²,

Ma³

et al. 2021

CMAR

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Background Long noncoding RNA (lncRNA) has been reported to play important roles in tumor initiation. However, how lncRNA ELFN1-AS1 affects retinoblastoma development remains unclear. Thus, we sought to elucidate its functions in retinoblastoma progression. Methods ELFN1-AS1 expression was measured in retinoblastoma tissues and normal tissues by qRT-PCR. CCK8, colony formation and Transwell assay were carried out to investigate the effects of ELFN1-AS1 knockdown on cell malignant behaviors. Bioinformatics analyses were performed to predict the relationship among ELFN1-AS1, miR-4270 and SBK1. Results ELFN1-AS1 was highly expressed in retinoblastoma tissues and cell lines. ELFN1-AS1 was positively correlated with retinoblastoma progression and prognosis. ELFN1-AS1 knockdown curtailed retinoblastoma proliferation, migration and invasion. ELFN1-AS1 was the competing endogenous RNA for miR-4270 and promoted SBK1expression. Conclusion Altogether, our findings demonstrated that ELFN1-AS1 promotes retinoblastoma progression through mediating miR-4270/SBK1 axis and might be a promising therapeutic target.

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Section: Discussionmentioning

confidence: 99%

LncRNA ELFN1-AS1 Promotes Retinoblastoma Growth and Invasion via Regulating miR-4270/SBK1 Axis

Feng¹,

Zhu²,

Ma³

et al. 2021

CMAR

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“…Deepening this observation, high expression of DLX6-AS1 was positively correlated with poor differentiation and advanced NB stage and, therefore, with a poor outcome [63,64]. Moreover, the upregulation of DLX6-AS1 has been correlated to the proliferation, migration and invasion in lung adenocarcinoma [65], gastric cancer [66], colorectal cancer (CRC) [67], breast cancer [68], bladder cancer [69], ovarian cancer [70] and osteosarcoma [71].…”

Section: Dlx6-as1mentioning

confidence: 99%

An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

Baldini

Calderoni

Vergani

et al. 2021

IJMS

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Neuroblastoma (NB) is a heterogeneous developmental tumor occurring in childhood, which arises from the embryonic sympathoadrenal cells of the neural crest. Although the recent progress that has been done on this tumor, the mechanisms involved in NB are still partially unknown. Despite some genetic aberrations having been identified, the sporadic cases represent the majority. Due to its wide heterogeneity in clinical behavior and etiology, NB represents a challenge in terms of prevention and treatment. Since a definitive therapy is lacking so far, there is an urgent necessity to unveil the molecular mechanisms behind NB onset and progression to develop new therapeutic approaches. Long non-coding RNAs (lncRNAs) are a group of RNAs longer than 200 nucleotides. Whether lncRNAs are destined to become a protein or not, they exert multiple biological functions such as regulating gene expression and functions. In recent decades, different research has highlighted the possible role of lncRNAs in the pathogenesis of many diseases, including cancer. Moreover, lncRNAs may represent potential markers or targets for diagnosis and treatment of diseases. This mini-review aimed to briefly summarize the most recent findings on the involvement of some lncRNAs in NB disease by focusing on their mechanisms of action and possible role in unveiling NB onset and progression.

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“…OC cell growth and motility are repressed as a consequence of MAGI2-AS3 induced overexpression. Conversely, the silencing of DLX6-AS1 (distal-less homeobox 6 antisense RNA 1) impaired proliferation, migration, and invasion abilities of OC cells, besides inducing their apoptosis and repressing tumor growth in vivo [25]. Increased levels of DLX6-AS1 were detected in OC cells and tissues [25].…”

Section: Lncrnas and Their Association With Ovarian Cancermentioning

confidence: 99%

“…Conversely, the silencing of DLX6-AS1 (distal-less homeobox 6 antisense RNA 1) impaired proliferation, migration, and invasion abilities of OC cells, besides inducing their apoptosis and repressing tumor growth in vivo [25]. Increased levels of DLX6-AS1 were detected in OC cells and tissues [25]. The authors demonstrated that DLX6-AS1 acts by sponging the miR-195-5p and upregulating its miRNA-target FHL2 (four and a half LIM domains 2).…”

Section: Lncrnas and Their Association With Ovarian Cancermentioning

confidence: 99%

“…The interplay between differentially expressed lncRNAs, such as MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and CDKN2B-AS1 (cyclin-dependent kinase inhibitor 2B antisense RNA 1), and histone-modifying or chromatin-remodeling complexes has been implicated in transcriptional regulation, enabling progression of different cancer types [24]. A set of the OC-related lncRNAs acts as oncogenes or tumor suppressors, contributing to cellular transformation [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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The Interplay between Long Noncoding RNAs and Proteins of the Epigenetic Machinery in Ovarian Cancer

Calanca

Abildgaard

Rainho

et al. 2020

Cancers

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Comprehensive large-scale sequencing and bioinformatics analyses have uncovered a myriad of cancer-associated long noncoding RNAs (lncRNAs). Aberrant expression of lncRNAs is associated with epigenetic reprogramming during tumor development and progression, mainly due to their ability to interact with DNA, RNA, or proteins to regulate gene expression. LncRNAs participate in the control of gene expression patterns during development and cell differentiation and can be cell and cancer type specific. In this review, we described the potential of lncRNAs for clinical applications in ovarian cancer (OC). OC is a complex and heterogeneous disease characterized by relapse, chemoresistance, and high mortality rates. Despite advances in diagnosis and treatment, no significant improvements in long-term survival were observed in OC patients. A set of lncRNAs was associated with survival and response to therapy in this malignancy. We manually curated databases and used bioinformatics tools to identify lncRNAs implicated in the epigenetic regulation, along with examples of direct interactions between the lncRNAs and proteins of the epigenetic machinery in OC. The resources and mechanisms presented herein can improve the understanding of OC biology and provide the basis for further investigations regarding the selection of novel biomarkers and therapeutic targets.

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LncRNA DLX6-AS1 aggravates the development of ovarian cancer via modulating FHL2 by sponging miR-195-5p

Cited by 25 publications

References 39 publications

LncRNA ELFN1-AS1 Promotes Retinoblastoma Growth and Invasion via Regulating miR-4270/SBK1 Axis

LncRNA ELFN1-AS1 Promotes Retinoblastoma Growth and Invasion via Regulating miR-4270/SBK1 Axis

An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

The Interplay between Long Noncoding RNAs and Proteins of the Epigenetic Machinery in Ovarian Cancer

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