LncRNA EGOT/miR-211-5p Affected Radiosensitivity of Rectal Cancer by Competitively Regulating ErbB4

Li, Chunxiang; Liu, Hengchang; Wei, Ran; Zheng, Lianwen; Chen, Haipeng; Guan, Xu; Zhao, Zhixun; Wang, Xishan; Jiang, Zheng

doi:10.2147/ott.s256989

Cited by 15 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supplementary Table S2 listed the lncRNAs involved in cancer radioresistance/radiosensitivity and their concise mechanisms. The sources of cancer included bladder cancer ( Tan et al, 2015 ; Jiang et al, 2017 ), breast cancer ( Liu et al, 2019a ; Zhang et al, 2019a ; Wang et al, 2019 ; Qian et al, 2020 ; Zhang et al, 2020a ), cardiac cancer ( Jia et al, 2019 ), gastric cancer ( Jiang et al, 2020 ; Lu et al, 2020 ; Xiao et al, 2020 ), cervical cancer ( Jing et al, 2015 ; Li et al, 2018a ; Han et al, 2018 ; Gao et al, 2019 ; Zhao et al, 2019 ; Wang et al, 2020a ; Ge et al, 2020 ), colorectal cancer ( Liu et al, 2020a ; Liu et al, 2020b ; Li et al, 2021 ; Liang et al, 2021 ), esophageal cancer ( Li et al, 2017 ; Chen et al, 2018a ; Zhang et al, 2019b ; Wang et al, 2020b ; Cheng et al, 2020 ; Liu et al, 2021a ; Sun et al, 2021 ; Yang et al, 2021 ), glioblastoma ( Li et al, 2018b ; Ahmadov et al, 2021 ; Li et al, 2022 ), glioma ( Yang et al, 2016 ; Zheng et al, 2016 ; Wang et al, 2020c ; Wang et al, 2020d ; Tang et al, 2020 ; Zheng et al, 2020 ; Gao et al, 2021 ; Tian et al, 2021 ), head and neck squamous cell cancer ( Li et al, 2020a ), laryngeal cancer ( Cui et al, 2019 ; Tang et al, 2019 ; Tang and Shan, 2019 ), nasopharyngeal cancer ( Jin et al, 2016 ; Wang et al, 2017 ; Ma et al, 2018 ; Yi et al, 2019 ; Han et al, 2020a ; Han et al, 2020b ; Wang et al, 2020e ; ...…”

Section: Resultsmentioning

confidence: 99%

“…ACK1 (activated CDC42 kinase 1) is a serine/threonine-protein kinase that contributes to cancer migration, survival, and proliferation via regulating WWOX and AKT1 ( Mahajan and Mahajan, 2013 ). In rectal cancer, lncRNA EGOT enhanced radioresistance via miR-211-5p/ErbB4 axis ( Li et al, 2021 ). ErbB4 (erb-b2 receptor tyrosine kinase 4) is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, and a tyrosine kinase domain.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review

Zhang

2022

Front. Pharmacol.

View full text Add to dashboard Cite

Background and purpose: Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity.Material and methods: The electronic databases Pubmed, Embase, and Google Scholar were searched from January 2000 to December 2021 to identify studies addressing the mechanisms of lncRNAs in tumor radioresistance/sensitivity, each of which required both in vivo and in vitro experiments.Results: Among the 87 studies identified, lncRNAs were implicated in tumor radioresistance/sensitivity mainly in three paradigms. 1) lncRNAs act on microRNA (miRNA) by means of a sponge, and their downstream signals include some specific molecular biological processes (DNA repair and chromosome stabilization, mRNA or protein stabilization, cell cycle and proliferation, apoptosis-related pathways, autophagy-related pathways, epithelial-mesenchymal transition (EMT), cellular energy metabolism) and some signaling mediators (transcription factors, kinases, some important signal transduction pathways) that regulate various biological processes. 2) lncRNAs directly interact with proteins, affecting the cell cycle and autophagy to contribute to tumor radioresistance. 3) lncRNAs act like transcription factors to initiate downstream signaling pathways and participate in tumor radioresistance.Conclusion: lncRNAs are important regulators involved in tumor radioresistance\sensitivity. Different lncRNAs may participate in the radioresistance with the same regulatory paradigm, and the same lncRNAs may also participate in the radioresistance in different ways. Future research should focus more on comprehensively characterizing the mechanisms of lncRNAs in tumor radioresistance to help us identify corresponding novel biomarkers and develop new lncRNA-based methods to improve radioresistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review

Zhang

2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…122 The overexpression of lncRNA-EGOT in rectal cancers induces ErbB4 mRNA expression by targeting miR-211-5p, therefore hampering apoptosis and facilitating cell proliferation, which are both critical to increased CRT resistance. 123 Unfortunately, there are few studies investigating the correlation between circRNA-miRNA-mRNA networks and nCRT resistance in LARC patients, which is a breakthrough worth anticipating.…”

Section: Ncrt Resistance/sensitivity-related Cernasmentioning

confidence: 99%

ceRNA Networks: The Backbone Role in Neoadjuvant Chemoradiotherapy Resistance/Sensitivity of Locally Advanced Rectal Cancer

Chang

et al. 2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

Approximately 40% of rectal cancers during initial diagnosis are identified as locally advanced rectal cancers (LARCs), for which the standardized treatment scenario is total mesorectal excision following neoadjuvant chemoradiotherapy (nCRT). nCRT can lead to discernible reductions in local relapse rate and distant metastasis rate in LARC patients, in whom previously inoperable tumors may potentially be surgically removed. However, only 4% to 20% cases can attain pathological complete response, and the remaining patients who are unresponsive to nCRT have to suffer from the side effects plus toxicities and may encounter poor survival outcomes due to the late surgical intervention. As such, employing potential biomarkers to differentiate responders from nonresponders before nCRT implementation appears to be the overarching goal. Well-defined competing endogenous RNA (ceRNA) networks include long noncoding RNA (lncRNA)-microRNA (miRNA)-mRNA and circRNA-miRNA-mRNA networks. As ceRNAs, lncRNAs, and circRNAs sponge miRNAs to indirectly suppress miRNAs downstream of oncogenic mRNAs or tumor-suppressive mRNAs. The abnormal expression of mRNAs regulates the nCRT-induced DNA damage repair process through pluralistic carcinogenic signaling pathways, thereby bringing about alterations in the nCRT resistance/sensitivity of tumors. Moreover, many molecular mechanisms relevant to cell proliferation, metastasis, or apoptosis of cancers (eg, epithelial-mesenchymal transition and caspase-9-caspase-3 pathway) are influenced by ceRNA networks. Herein, we reviewed a large group of abnormally expressed mRNAs and noncoding RNAs that are associated with nCRT resistance/sensitivity in LARC patients and ultimately pinpointed the backbone role of ceRNA networks in the molecular mechanisms of nCRT resistance/sensitivity.

show abstract

“…Lnc-EGOT was upregulated in RC tissues and cell lines. Lnc-EGOT significantly facilitated cell growth and inhibited the irradiation-induced apoptosis of RC cells, thereby resulting in cell resistance to RT ( Li et al, 2021b ). Thus, ncRNAs play critical roles in the resistance of gastrointestinal carcinoma to irradiation.…”

Section: Introductionmentioning

confidence: 99%

“…Lnc-TRPM2-AS resulted in the resistance of GC cells to irradiation via modulating the IGF2BP1 and FOXM1 expression by sponging miR-612 ( Xiao et al, 2020 ). Lnc-EGOT conferred the resistance to RT in RC cells via accumulating ErbB4 by sponging miR-211-5p ( Li et al, 2021b ). Lnc-RI conferred radioresistance to CRC cells by adjusting LIG4 expression via binding to the miR-4727-5p ( Liu et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

The Roles of Non-Coding RNAs in Radiotherapy of Gastrointestinal Carcinoma

Sun

Liu

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Radiotherapy (RT), or radiation therapy, has been widely used in clinical practice for the treatment of local advanced gastrointestinal carcinoma. RT causes DNA double-strand breaks leading to cell cytotoxicity and indirectly damages tumor cells by activating downstream genes. Non-coding RNA (including microRNAs, long non-coding RNAs (ncRNAs), and circular RNAs) is a type of RNA that does not encode a protein. As the field of ncRNAs increasingly expands, new complex roles have gradually emerged for ncRNAs in RT. It has been shown that ncRNAs can act as radiosensitivity regulators in gastrointestinal carcinoma by affecting DNA damage repair, cell cycle arrest, irradiation-induced apoptosis, cell autophagy, stemness, EMT, and cell pyroptosis. Here, we review the complex roles of ncRNAs in RT and gastrointestinal carcinoma. We also discuss the potential clinical significance and predictive value of ncRNAs in response to RT for guiding the individualized treatment of patients. This review can serve as a guide for the application of ncRNAs as radiosensitivity enhancers, radioresistance inducers, and predictors of response in RT of gastrointestinal carcinoma.

show abstract

LncRNA EGOT/miR-211-5p Affected Radiosensitivity of Rectal Cancer by Competitively Regulating ErbB4

Cited by 15 publications

References 41 publications

The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review

The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review

ceRNA Networks: The Backbone Role in Neoadjuvant Chemoradiotherapy Resistance/Sensitivity of Locally Advanced Rectal Cancer

The Roles of Non-Coding RNAs in Radiotherapy of Gastrointestinal Carcinoma

Contact Info

Product

Resources

About