LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells

Chen, Jingxin; Chen, Xubin; Fu, Liangbin; Ji-min, Chen; Yang, Chen; Liu, Feng

doi:10.18632/aging.203416

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…Moreover, FGF9 high expression in CAFs of lymph node metastatic sites was associated with poor prognosis in GC [60][61][62]. MiRNA-149 also plays a role in inhibiting tumor [63][64][65][66][67].…”

Section: Cytokines and Chemokines During Tumor Progression Different ...mentioning

confidence: 99%

Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer

Zhang¹,

Guan²,

Li³

et al. 2022

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Gastric cancer (GC) is the fifth most common malignancy and the fourth leading cause of cancerrelated death worldwide. Cancer-associated fibroblasts (CAFs), an important cell type in the tumor microenvironment, play an important role in GC development. In this review, we describe the current knowledge of CAFs' heterogeneity and their role in GC invasion and metastasis. Currently, CAF-targeted cancer therapies are being rapidly explored and developed. However, the heterogeneity of CAFs limits the application of this therapy, so it is urgent to find specific markers and divide them into different subpopulations. With the development of single-cell RNA sequencing technology, researchers have used this technology to classify CAFs in many tumors, but whether it is applicable to GC and other tumors needs further study. And we believe that this technology will be in the near future utilized to sort CAFs on the basis of different cell markers and functions, so as to target tumor-promoting CAFs and inhibit tumor progression. Targeting CAFs by cell surface markers or normalizing the activated CAFs subsets may be an effective therapy, alone or in combination with other therapeutic approaches for GC treatment. Therefore, in the coming decades, the interaction between CAFs and GC cells will be still the focus of our research.

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Section: Cytokines and Chemokines During Tumor Progression Different ...mentioning

confidence: 99%

Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer

Zhang¹,

Guan²,

Li³

et al. 2022

neo

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“…Furthermore, GACAT1 knockdown promoted autophagy and apoptosis while inhibiting proliferation and metastasis in OSPECAPJ41 and HSC-4CC OSCC cell lines. Interestingly, when the miR-149 inhibitor was applied, the results were reversed, indicating that the lncRNA GACAT1 and miR-149 are promising therapeutic targets in OSCC ( Chen et al, 2021 ). Similarly, in HSC-3 and HSC-4 OSCC cell lines, autophagy and proliferation were inhibited by the effect of miR-1301-3p on the carcinogenic gene lactate dehydrogenase A (LDHA), and apoptosis was promoted.…”

Section: Autophagy-related Biomarkers In Osccmentioning

confidence: 99%

Unravelling the roles of Autophagy in OSCC: A renewed perspective from mechanisms to potential applications

2022

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Oral squamous cell carcinoma (OSCC) is associated with a low survival rate and a high disability rate, making it a serious health burden, particularly in Southeast Asian countries. Therefore, improvements in the diagnosis, treatment, and prognosis prediction of OSCC are highly warranted. Autophagy has a significant impact on cancer development. Studies on autophagy in various human cancers have made outstanding contributions; however, the relationship between autophagy and OSCC remains to be explored. This review highlights the roles of autophagy in OSCC and discusses the relationship between autophagy and Epithelial–mesenchymal transition. Considering the lack of OSCC biomarkers, we focus on the studies involving OSCC-related bioinformatics analysis and molecular targets. Based on some classical targets, we summarize several key autophagy-related biomarkers with a considerable potential for clinical application, which may become the hotspot of OSCC research. In conclusion, we elaborate on the interrelationship between autophagy and OSCC and highlight the shortcomings of current studies to provide insights into the potential clinical strategies.

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“…Another study by Chen et al. showed that when the gastric cancer-associated transcript 1 (GACAT1) was inhibited in OSCC samples, it promoted apoptosis and autophagy, mainly related to the targeting of miRNA-149 ( 93 ). Long intergenic non-coding RNA 01207 (LINC01207) and LINC00958 were also upregulated in OSCC tissues and cells.…”

Section: Lncrnas In Drug Resistance Mechanismsmentioning

confidence: 99%

Emerging role of lncRNAs in drug resistance mechanisms in head and neck squamous cell carcinoma

et al. 2022

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Head and neck squamous cell carcinoma (HNSCC) originates in the squamous cell lining the mucosal surfaces of the head and neck region, including the oral cavity, nasopharynx, tonsils, oropharynx, larynx, and hypopharynx. The heterogeneity, anatomical, and functional characteristics of the patient make the HNSCC a complex and difficult-to-treat disease, leading to a poor survival rate and a decreased quality of life due to the loss of important physiologic functions and aggressive surgical injury. Alteration of driver-oncogenic and tumor-suppressing lncRNAs has recently been recently in HNSCC to obtain possible biomarkers for diagnostic, prognostic, and therapeutic approaches. This review provides current knowledge about the implication of lncRNAs in drug resistance mechanisms in HNSCC. Chemotherapy resistance is a major therapeutic challenge in HNSCC in which lncRNAs are implicated. Lately, it has been shown that lncRNAs involved in autophagy induced by chemotherapy and epithelial–mesenchymal transition (EMT) can act as mechanisms of resistance to anticancer drugs. Conversely, lncRNAs involved in mesenchymal–epithelial transition (MET) are related to chemosensitivity and inhibition of invasiveness of drug-resistant cells. In this regard, long non-coding RNAs (lncRNAs) play a pivotal role in both processes and are important for cancer detection, progression, diagnosis, therapy response, and prognostic values. As the involvement of more lncRNAs is elucidated in chemoresistance mechanisms, an improvement in diagnostic and prognostic tools could promote an advance in targeted and specific therapies in precision oncology.

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LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells

Cited by 10 publications

References 23 publications

Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer

Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer

Unravelling the roles of Autophagy in OSCC: A renewed perspective from mechanisms to potential applications

Emerging role of lncRNAs in drug resistance mechanisms in head and neck squamous cell carcinoma

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