2022
DOI: 10.1186/s12890-022-02091-y
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LncRNA H19 alleviates sepsis-induced acute lung injury by regulating the miR-107/TGFBR3 axis

Abstract: Objective Acute lung injury (ALI) increases sepsis morbidity and mortality. LncRNA H19 plays a critical role in sepsis. miR-107 is highly-expressed and TGFβ type III receptor (TGFBR3) is poorly-expressed in sepsis, yet their roles in sepsis development require further investigation. This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. Methods Mice were intravenously injected with A… Show more

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Cited by 10 publications
(4 citation statements)
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“…Briefly, the lungs and ileum were fixed in 10% formalin. The tissues were then placed in paraffin and sectioned, and sections were stained with H&E. The injury of lungs and ileum were scored in a blinded fashion as previously reported[ 26 , 27 ].…”
Section: Methodsmentioning
confidence: 99%
“…Briefly, the lungs and ileum were fixed in 10% formalin. The tissues were then placed in paraffin and sectioned, and sections were stained with H&E. The injury of lungs and ileum were scored in a blinded fashion as previously reported[ 26 , 27 ].…”
Section: Methodsmentioning
confidence: 99%
“…However, these all lncRNAs cause increased expression level of Bcl-2, inhibition of apoptosis, and tumor progression ultimately (31)(32)(33)(34). Among them, lncRNA H19 plays a role in sepsis, myocardial injury, and vascular smooth muscle injury in addition to acting in cholangiocarcinoma (35)(36)(37). LncRNAs can induce or inhibit apoptosis by regulating apoptosis-related molecules in the caspase family.…”
Section: Apoptosis and Lncrnas In Tumorsmentioning
confidence: 99%
“…The levels of Interleukin (IL)-1β (ab197742; Abcam, Shanghai, China), IL-6 (ab222503), IL-10 (ab255729), and IL-17 (ab100702) in BALF were quantified using commercially available ELISA kits. 18…”
Section: Enzyme-linked Immunosorbent Serological Assay (Elisa)mentioning
confidence: 99%