LncRNA HOTAIR in exercise-induced neuro-protective function in Alzheimer’s disease

Abstract

Introduction: Exercise is effective in Alzheimer's disease (AD), which is characterized by neuro-degenerative progress with increasing morbidity. The present study aimed to explore whether HOTAIR participated in the regulation of exercise in AD. Material and methods: A relative expression of serum HOTAIR was detected using quantitative real-time polymerase chain reaction (PCR). The diagnostic significance of HOTAIR on distinguishing AD patients was evaluated by receiver operating characteristic (ROC) curve. Correlations between HOTAIR expression and Mini-Mental State Examination (MMSE) score or Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) score were analyzed with Pearson's test. Logistic regression analysis was applied to investigate factors as independent indicators for HOTAIR expression.Results: In AD patients, the expression of HOTAIR was increased, and it could function as a diagnostic marker in AD patients. The expression of HOTAIR was associated with MMSE score and ADAS-Cog score in AD patients before exercise. Exercise ameliorated the cognitive impairment and reduced the relative serum expression of HOTAIR. Exercise was proved to be an independent indicator of HOTAIR expression. Conclusions: HOTAIR was a possible biomarker for indicating AD patients, and it was correlated with MMSE scores and ADAS-Cog results. Exercise might moderate AD progress via controlling HOTAIR.

The multifaceted functions of long non-coding RNAHOTAIRin neuropathologies and its potential as a prognostic marker and therapeutic biotarget

“…26), which may, at least in part, be dependent on the altered expression levels of lncRNAs, such as NEAT1 and HOTAIR. In support of this idea, HOTAIR has been observed 28). In spite of these data supporting a probable role of HOTAIR in AD pathogenesis, the exact identities of the molecular and cellular pathways have remained obscure and might represent an interesting area of research in the coming years.…”

“…Indeed, a 3-month long bicycle training regimen significantly reduced the serum levels of HOTAIR with concomitant attenuation of AD-linked cognitive impairment (Ref. 28). In spite of these data supporting a probable role of HOTAIR in AD pathogenesis, the exact identities of the molecular and cellular pathways have remained obscure and might represent an interesting area of research in the coming years.…”

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

“…Hence, region-specific alterations in HOTAIR expression in brain tissue samples obtained from clinical subjects of AD may contribute to disease pathology via altering Cdk5 signaling (Spreafico et al 2018 ). Further, elevated serum expression of HOTAIR in AD patients has been reported to elicit close associations with the severity of cognitive and memory impairments (Lu et al 2022b ), encouraging the proposition of serum HOTAIR levels as a biomarker for cognitive decline in AD. Interestingly, a 3-month bicycle training paradigm resulted in significant reductions in the serum HOTAIR levels in these clinical subjects, concomitantly with robust attenuation of AD-linked cognitive impairment (Lu et al 2022b ).…”

Non-Coding RNA in Microglia Activation and Neuroinflammation in Alzheimer’s Disease

“…Exercise is an independent indicator of HOTAIR expression. 261 Similarly, another study suggests that exercise can mitigate learning ability deficits, reduce inflammation, and inhibit HOTAIR expression in AD mice. The elevated expression of HOTAIR suppresses the beneficial effects of voluntary exercise (VE) on IL-6, IL-1β, and TNF-α levels, as well as cognitive function and inflammation.…”