LncRNA HULC as a potential predictor of prognosis and clinicopathological features in patients with digestive system tumors: a meta-analysis

Li, Duo; Wang, Rui; Wu, Na; Yu, Yongqiang

doi:10.18632/aging.203903

Cited by 7 publications

(9 citation statements)

References 66 publications

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“…As another research hotspot, 23 studies about SC were included in this study ( 25 , 27 , 36 , 44 – 46 , 52 – 68 ). Two studies related to circRNA ( 36 , 53 ).…”

Section: Resultsmentioning

confidence: 99%

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Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

et al. 2023

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AimProvide an overview and a systematic evaluation of the evidence quality on the association between non-coding RNAs (ncRNAs) and prognosis value for gastrointestinal cancers (GICs).MethodsWe searched the literature from three electronic databases: Pubmed, Embase, and Web of science, then carefully screened and extracted the primary information and results from the included articles. We use A measurable systematic review and meta-analysis evaluation tool (AMSTAR2) to evaluate the quality of methodology and then use the Grading of Recommendations Assessment 2, Development and Evaluation guideline (GRADE) make sure the reliability of the meta-analysis.ResultsOverall, 182 meta-analyses from 58 studies were included in this study. Most of these studies are of low or very low quality. Using the scoring tool, we found that only two meta-analyses were rated as high reliability, and 17 meta-analyses were rated as medium reliability.ConclusionsAlthough ncRNA has good prognostic value in some studies, only a tiny amount of evidence is highly credible at present. More research is needed in the future.PROSPERO registration numberCRD42022382296.

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“…As another research hotspot, 23 studies about SC were included in this study ( 25 , 27 , 36 , 44 – 46 , 52 – 68 ). Two studies related to circRNA ( 36 , 53 ).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies have reported the prognostic value of lncRNA for PC respectively ( 27 , 71 ). At the same time, four other studies reported the situation of miRNA ( 38 , 45 , 70 , 79 ).…”

Section: Resultsmentioning

confidence: 99%

Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

et al. 2023

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“…Our study has some strengths (1) Our research focuses on preoperative (admission) D-dimer, avoiding signi cant uctuations in Ddimer values caused by different surgical types and ranges. (2) We addressed the nonlinear problem in this study and further explored it; (3) this study is an observational study and therefore susceptible to potential confounding. We used strict statistical adjustment to minimize residual confounders (4) We handled target independent variable as both continuous variable and categorical variable.…”

Section: Tablementioning

confidence: 99%

“…As is known to all, digestive tract cancers (e.g., esophageal, gastric, and colorectal cancers) are common malignant tumors and major causes of mortality worldwide (1). According to the World Health Organization (WHO) tumor classi cation, digestive system tumors include esophageal cancer, gastric cancer, small intestinal cancer, hepatocellular carcinoma, gallbladder cancer, cholangiocarcinoma, pancreatic cancer, and colorectal cancer (2). Gastrointestinal (GI) cancer has the highest incidence and mortality rates of all cancers (3), it is also the leading cause of cancer-related deaths (4).…”

Section: Introductionmentioning

confidence: 99%

Preoperative D-dimer and 5-year overall survival rate in patients diagnosed with gastric cancer and undergoing gastric cancer radical surgery: a Retrospective cohort study

Lu,

Zhao,

Han

et al. 2024

Preprint

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Background As one of the most malignant tumors of the digestive tract, gastric cancer has a high incidence rate and mortality rate in recent years, and lacks significant prognostic indicators. D-dimer, as a degradation product of fibrin, is a conventional biomarker for coagulation and has been studied to have potential promoting effects on postoperative cancer patients. However, there are also contradictory results, with some studies reporting a promoting effect, while others have not shown any effect. Therefore, the actual impact of D-dimer on the prognosis of postoperative cancer patients remains controversial, and further research is needed on the linear and nonlinear regression relationship and optimal critical values between D-dimer and postoperative cancer patients before surgery. Therefore, our aim is to evaluate the relationship between preoperative D-dimer and 5-year overall survival in patients undergoing gastric cancer radical surgery. Methods We used patients diagnosed with gastric cancer and underwent radical gastrectomy at Shanxi Cancer Hospital (Cancer Hospital of the Chinese Academy of Medical Sciences) in 2017 to explore the relationship between preoperative D-dimer and prognosis of gastric cancer. We obtained preoperative D-dimer data and tumor related indicators as covariates from the hospital medical record system, and obtained patient follow-up information from the hospital follow-up system. This study used multivariate Cox regression, curve fitting, and inflection point analysis to explore the correlation between preoperative D-dimer and 5-year overall survival after gastric cancer radical surgery. Results After strict admission and exclusion procedures, a total of 133 patients were included in the study, and we classified them based on D-dimer. Divide D-dimer into two groups on average: high group (n = 66) and low group (n = 67). Subsequently, Cox multiple regression analysis was conducted using both continuous and binary variables. Therefore, the results showed no effect in continuous variables, but significant presence in categorical variables (Table 3). Therefore, we performed curve fitting, and in the curve fitting, preoperative D-dimer. The relationship between dimer and 5-year survival rate after radical gastrectomy for cancer shows a U-shaped or J-shaped curve with p < 0.001 (Fig. 2). Prove a curved relationship between preoperative D-dimer and 5-year survival rate after radical gastrectomy for cancer. Subsequently, we conducted an inflection point analysis (Table 2) (Fig. 2), BK. Hour: 110.449 (106.956 ,113.942). Conclusion In patients undergoing radical gastrectomy for gastric cancer, preoperative D-dimer There is a U-shaped relationship between dimer and 5-year postoperative survival in gastric cancer.

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“…Several studies have confirmed that lncRNAs are aberrantly expressed in HCC and may play a key role in the development of HCC. For example, highly upregulated in liver cancer (HULC) is located at is located on the chromosome 6p24.3, producing a long RNA that was discovered as upregulated in HCC and is associated with cancer progression [ 26 ]. WRAP53 in peripheral blood is an independent prognostic marker predicting high recurrence rates in HCC patients [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Creation of a Prognostic Model Using Cuproptosis-Associated Long Noncoding RNAs in Hepatocellular Carcinoma

Yang,

Jia,

et al. 2023

IJMS

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Cuproptosis is an unusual form of cell death caused by copper accumulation in mitochondria. Cuproptosis is associated with hepatocellular carcinoma (HCC). Long noncoding RNAs (LncRNAs) have been shown to be effective prognostic biomarkers, yet the link between lncRNAs and cuproptosis remains unclear. We aimed to build a prognostic model of lncRNA risk and explore potential biomarkers of cuproptosis in HCC. Pearson correlations were used to derive lncRNAs co-expressed in cuproptosis. The model was constructed using Cox, Lasso, and multivariate Cox regressions. Kaplan–Meier survival analysis, principal components analysis, receiver operating characteristic curve, and nomogram analyses were carried out for validation. Seven lncRNAs were identified as prognostic factors. A risk model was an independent prognostic predictor. Among these seven lncRNAs, prostate cancer associated transcript 6 (PCAT6) is highly expressed in different types of cancer, activating Wnt, PI3K/Akt/mTOR, and other pathways; therefore, we performed further functional validation of PCAT6 in HCC. Reverse transcription–polymerase chain reaction results showed that PCAT6 was aberrantly highly expressed in HCC cell lines (HepG2 and Hep3B) compared to LO2 (normal hepatocytes). When its expression was knocked down, cells proliferated and migrated less. PCAT6 might be a potential biomarker for predicting prognosis in HCC.

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LncRNA HULC as a potential predictor of prognosis and clinicopathological features in patients with digestive system tumors: a meta-analysis

Cited by 7 publications

References 66 publications

Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Preoperative D-dimer and 5-year overall survival rate in patients diagnosed with gastric cancer and undergoing gastric cancer radical surgery: a Retrospective cohort study

Creation of a Prognostic Model Using Cuproptosis-Associated Long Noncoding RNAs in Hepatocellular Carcinoma

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