LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

Yan, Jijun; Huang, Xiaofeng; Zhang, Xiongjie; Chen, Zhijie; Ye, Chao; Xiang, Wencai; Huang, Zhengbin

doi:10.1016/j.bbrc.2019.11.016

Cited by 90 publications

(88 citation statements)

References 20 publications

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“…LINC00189 is associated with cervical cancer recurrence and may be used as a potential prognostic biomarker (73). Upregulated LINC00470 expression promotes the development of gastric cancer (74). LINC00896 expression is upregulated in human lung adenocarcinoma (75) and MIR205HG is differentially expressed in papillary renal cell carcinoma (76).…”

Section: Discussionmentioning

confidence: 99%

An optimal prognostic model based on gene expression for clear cell renal cell carcinoma

Dang

Wang

et al. 2020

Oncol Lett

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Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of RCC; however, prognostic prediction tools for ccRCC are scant. Developing mRNA or long non-coding RNA (lncRNA)-based risk assessment tools may improve the prognosis in patients with ccRCC. RNA-sequencing and prognostic data from patients with ccRCC were downloaded from The Cancer Genome Atlas and the European Bioinformatics Institute Array database at the National Center for Biotechnology Information. Differentially expressed (DE) RNAs (DERs) and prognostic DERs were screened between less favorable and favorable prognoses using the limma package in R 3.4.1, and analyzed using univariate and multivariate Cox regression analyses, respectively. Risk score models were constructed using optimal combinations of DEmRNAs and DElncRNAs identified using the Least Absolute Shrinkage And Selection Operator Cox regression model of the penalized package. Associations between risk score models and overall survival time were evaluated. Independent prognostic clinical factors were screened using univariate and multivariate Cox regression analyses, and nomogram models were constructed. Gene Ontology biological processes and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted using the clusterProfiler package in R3.4.1. A total of 451 DERs were identified, including 404 mRNAs and 47 lncRNAs, between less favorable and favorable prognoses, and 269 DERs, including 233 mRNAs and 36 lncRNAs, were identified as independent prognostic factors. Optimal combinations including 10 DEmRNAs or 10 DElncRNAs were screened using four risk score models based on the status or expression levels of the 10 DEmRNAs or 10 DElncRNAs. The model based on the expression levels of the 10 DEmRNAs had the highest prognostic power. These prognostic DEmRNAs may be involved in biological processes associated with the inflammatory response, complement and coagulation cascades and neuroactive ligand-receptor interaction pathways. The present validated risk assessment tool based on the expression levels of these 10 DEmRNAs may help to identify patients with ccRCC at a high risk of mortality. These 10 DEmRNAs in optimal combinations may serve as prognostic biomarkers and help to elucidate the pathogenesis of ccRCC.

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Section: Discussionmentioning

confidence: 99%

An optimal prognostic model based on gene expression for clear cell renal cell carcinoma

Dang

Wang

et al. 2020

Oncol Lett

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“…LncRNA derived from hepatocytes (lnc-HC) interacts with HNRNPA2B1 to inhibit cholesterol metabolism in hepatocytes [96]. Long intergenic non-protein coding RNA 470 (LINC00470) interacts with METTL3 to suppress the stability of phosphatase and tensin homolog (PTEN) to facilitate GC progression [97]. LncRNA miR503 host gene (miR503HG) also interacts with HNRNPA2B1 to promote its degradation through an ubiquitin-proteasome pathway in HCC [98].…”

Section: A Regulators Are Regulated By Ncrnas In Cancermentioning

confidence: 99%

Novel insights into the interplay between m6A modification and noncoding RNAs in cancer

et al. 2020

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N6-methyladenosine (m 6 A) is one of the most common RNA modifications in eukaryotes, mainly in messenger RNA (mRNA). Increasing evidence shows that m 6 A methylation modification acts an essential role in various physiological and pathological bioprocesses. Noncoding RNAs (ncRNAs), including miRNAs, lncRNAs and circRNAs, are known to participate in regulating cell differentiation, angiogenesis, immune response, inflammatory response and carcinogenesis. m 6 A regulators, such as METTL3, ALKBH5 and IGF2BP1 have been reported to execute a m 6 Adependent modification of ncRNAs involved in carcinogenesis. Meanwhile, ncRNAs can target or modulate m 6 A regulators to influence cancer development. In this review, we provide an insight into the interplay between m 6 A modification and ncRNAs in cancer.

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“…In addition to regulating mRNA, METTL3 also influences non-coding RNA metabolism in GC. For example, METTL3 interacts with the non-coding RNA LINC00470 to suppress phosphatase and tensin homolog (PTEN) mRNA stability, resulting in GC cell proliferation [34]. Recent findings showed that METTL3 expression was higher in CRC tissues than in normal tissues and that this feature indicated poor prognosis; upregulation of METTL3 promoted CRC tumor growth by stabilizing SRY-box 2 (SOX2) [43] and cyclin E1 (CCNE1) mRNA in an m 6 A-dependent manner [45].…”

Section: The Role Of Mettl3 In the Proliferation And Apoptosis Of Gasmentioning

confidence: 99%

Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer

et al. 2020

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Gastrointestinal cancer, the most common solid tumor, has a poor prognosis. With the development of highthroughput sequencing and detection technology, recent studies have suggested that many chemical modifications of human RNA are involved in the development of human diseases, including cancer. m 6 A, the most abundant modification, was revealed to participate in a series of aspects of cancer progression. Recent evidence has shown that methyltransferase-like 3 (METTL3), the first identified and a critical methyltransferase, catalyzes m 6 A methylation on mRNA or non-coding RNA in mammals, affecting RNA metabolism. Abnormal m 6 A levels caused by METTL3 have been reported to be involved in different aspects of cancer development, including proliferation, apoptosis, and metastasis. In this review, we will shed light on recent findings regarding the biological function of METTL3 in gastrointestinal cancer and discuss future research directions and potential clinical applications of METTL3 for gastrointestinal cancer.

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LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells

Cited by 90 publications

References 20 publications

An optimal prognostic model based on gene expression for clear cell renal cell carcinoma

An optimal prognostic model based on gene expression for clear cell renal cell carcinoma

Novel insights into the interplay between m6A modification and noncoding RNAs in cancer

Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer

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