LncRNA linc01194 promotes the progress of endometrial carcinoma by up-regulating SOX2 through binding to IGF2BP1

Huang, Zhenghao; Shen, Fan; Chen, Jingwen; Xie, Bumin; Chen, Xi; Zhao, Yang; Chen, Shuo

doi:10.3802/jgo.2024.35.e21

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Signaling pathways include extracellular matrix organization [101], nervous system development [102], signal transduction [103], hemostasis [104], muscle contraction [105], signaling by retinoic acid [106] and diseases of glycosylation [107] were responsible for advancement of endometriosis. Altered expression of L1CAM [108], HSD17B2 [109], VCAM1 [110], SOX6 [111], FGF10 [112], MMP12 [113], CCR1 [114], PROK1 [115], PRL (prolactin) [116], TIMP3 [117], ADAMTS9 [118], NDNF (neuron derived neurotrophic factor) [119], LHCGR (luteinizing hormone/choriogonadotropin receptor) [120], PDGFB (platelet derived growth factor subunit B) [121], LDLR (low density lipoprotein receptor) [122], CD4 [123], FOXL2 [124], TRPA1 [125], ADRB2 [126], PLAU (plasminogen activator, urokinase) [127], EPCAM (epithelial cell adhesion molecule) [128], UCN2 [129], CYP1A1 [130], NTN1 [131], IL15 [132], BMP2 [133], APOE (apolipoprotein E) [134], CASP1 [135], ABCG2 [136], ACE (angiotensin I converting enzyme) [137], PGR (progesterone receptor) [138], ALPP (alkaline phosphatase, placental) [139], LPAR4 [140], ATRNL1 [141], HLA-C [142], MMP3 [143], PDLIM3 [144], NFASC (neurofascin) [145], IL33 [146], NGF (nerve growth factor) [147], COMP (cartilage oligomeric matrix protein) [148], FST (follistatin) [149], EFEMP1 [150], GATA6 [151], TCF21 [152], PTGS2 [153], HOXC8 [154], AKR1C3 [155], BDNF (brain derived neurotrophic factor) [119], EPHA3 [156], INHBA (inhibin subunit beta A) [157], RAP1GAP [158], TLR3 [159], NOX4 [160], TGFBI (transforming growth factor beta induced) [161], IGF2BP1 [162], DLX5 [163], VDR (vitamin D receptor) [164], F...…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported that the L1CAM [386], HSD17B2 [387], GRP (gastrin releasing peptide) [388], FABP4 [389], SOX6 [390]. MMP12 [391], APOD (apolipoprotein D) [392], LAG3 [393], CST1 [394], FLT1 [395], DHCR24 [396], PRL (prolactin) [397], WNT5A [398], TIMP3 [399], CD24 [400], LHCGR (luteinizing hormone/choriogonadotropin receptor) [401], MMRN1 [402], CD4 [403], ADAMTS5 [404], ADAMTS1 [405], PADI2 [406], MARK1 [407], KL (klotho) [408], PLAU (plasminogen activator, urokinase) [409], SOX8 [410], CRABP2 [411], PTPRD (protein tyrosine phosphatase receptor type D) [412], EPCAM (epithelial cell adhesion molecule) [413], IRX2 [414], SEMA3B [415], CYP1A1 [416], PDGFD (platelet derived growth factor D) [417], LEPR (leptin receptor) [418], APOE (apolipoprotein E) [419], CASP1 [420], MGLL (monoglyceride lipase) [421], NID1 [422], ABCG2 [423], ACE (angiotensin I converting enzyme) [424], PGR (progesterone receptor) [425], HPSE2 [426], LMTK3 [427], ALPP (alkaline phosphatase, placental) [428], EGFL6 [429], CACNA2D3 [430], MCTP1 [431], HKDC1 [432], S100A4 [433], MACC1 [434], MMP3 [435], FGFR2 [436], IL33 [437], FOXC2 [438], ITGA7 [439], EFEMP1 [440], GATA6 [441], BHLHE41 [442], TCF21 [443], GDF10 [444], NKX3-1 [445], AKR1C3 [446], SGK1 [447], RAP1GAP [448], FLI1 [449], NOX4 [450], SERPINE2 [451], IGSF9 [452], IGF2BP1 [453], SALL4 [454], VDR (vitamin D receptor) [455], CELSR2 [456],...…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that CCND2 [1495], VCAM1 [1462], PTPRD (protein tyrosine phosphatase receptor type D) [1496], PRKCB (protein kinase C beta) [1476], IGF2BP1 [1545], hsa-mir-200a-3p [1681] and hsa-mir-10b-5p [1682] are an important biomarkers of diabetes mellitus. VCAM1 [110], PDGFB (platelet derived growth factor subunit B) [121], IGF2BP1 [162], DAPK1 [183] and hsa-mir-17-5p [1683] are a potential markers for the detection and prognosis of endometriosis. VCAM1 [1232], hsa-mir-17-5p [1684] and hsa-mir-2110 [1685] are a key initiator of polycystic ovarian syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…VCAM1 [1413], PTPRD (protein tyrosine phosphatase receptor type D) [1426] and hsa-mir-17-5p [1689] are associated with prognosis in patients with gestational diabetes mellitus. IGF2BP1 [453], DAPK1 [183], PTPRD (protein tyrosine phosphatase receptor type D) [412], TCF3 [1690], SMARCA4 [1691] and TRIM28 [1692] biomarkers are vital for endometrial cancer. Research have shown that PTPRD (protein tyrosine phosphatase receptor type D) [656], PDGFB (platelet derived growth factor subunit B) [642], DAPK1 [751], hsa-mir-4432 [1693], SMARCA4 [1694] and TRIM28 [1695] participates in hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Endometriosis is a common cause of endometrial-type mucosa outside the uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with intercourse and infertility. However, the early diagnosis of endometriosis is still restricted. The purpose of this investigation is to identify and validate the key biomarkers of endometriosis. Next generation sequencing (NGS) dataset GSE243039 was obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between endometriosis and normal control samples were identified. After screening of DEGs, gene ontology (GO) and REACTOME pathway enrichment analyses were performed. Furthermore, a protein-protein interaction (PPI) network was constructed and modules were analysed using the Human Integrated Protein-Protein Interaction rEference (HIPIE) database and Cytoscape software, and hub genes were identified. Subsequantely, a network between miRNAs and hub genes, and network between TFss and hub genes were constructed using the miRNet and NetworkAnalyst tool, and possible key miRNAs and TFs were predicted. Finally, receiver operating characteristic curve (ROC) analysis was used to validate the hub genes. A total of 958 DEGs, including 479 up regulated genes and 479 down regulated genes, were screened between endometriosis and normal control samples. GO and REACTOME pathway enrichment analyses of the 958 DEGs showed that they were mainly involved in multicellular organismal process, developmental process, signaling by GPCR and muscle contraction. Further analysis of the PPI network and modules identified 10 hub genes, including VCAM1, SNCA, PRKCB, ADRB2, FOXQ1, MDFI, ACTBL2, PRKD1, DAPK1 and ACTC1. Possible target miRNAs, including hsa-mir-3143 and hsa-mir-2110, and target TFs, including TCF3 and CLOCK, were predicted by constructing a miRNA-hub gene regulatory network and TF-hub gene regulatory network. This investigation used bioinformatics techniques to explore the potential and novel biomarkers. These biomarkers might provide new ideas and methods for the early diagnosis, treatment, and monitoring of endometriosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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“…This factor promotes the expression of sex-determining region Y-box 2 (SOX2). This gene increases tumour development and promotes metastasis occurrence [ 75 ]. Linc can either promote endometroid cancer proliferation by stimulating overexpression of VEGFA, and thus increases the angiogenesis of tumour vessels.…”

Section: The Role Of Lncrna In Endometrial Cancermentioning

confidence: 99%

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Jasielski,

Zawlik,

Bogaczyk

et al. 2024

Cancers

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Endometrial cancer is one of the most common malignant tumours in women. The development of this tumour is associated with several genetic disorders, many of which are still unknown. One type of RNA molecules currently being intensively studied in many types of cancer are long non-coding RNAs (lncRNAs). LncRNA-coding genes occupy a large fraction of the human genome. LncRNAs regulate many aspects of cell development, metabolism, and other physiological processes. Diverse types of lncRNA can function as a tumour suppressor or an oncogene that can alter migration, invasion, cell proliferation, apoptosis, and immune system response. Recent studies suggest that selected lncRNAs are important in an endometrial cancer course. Our article describes over 70 lncRNAs involved in the development of endometrial cancer, which were studied via in vivo and in vitro research. It was proved that lncRNAs could both promote and inhibit the development of endometrial cancer. In the future, lncRNAs may become an important therapeutic target. The aim of this study is to review the role of lncRNAs in the development of carcinoma of uterine body.

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Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases

Ma,

Qin,

Ren

2024

Mol Med

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The oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors. Numerous studies have demonstrated that IGF2BP1 plays crucial roles in embryogenesis and carcinogenesis. IGF2BP1-modulated cell proliferation, invasion, and chemo-resistance in solid tumors have attracted researchers’ attention. Additionally, several studies have highlighted the importance of IGF2BP1 in hematologic malignancies and hematological genetic diseases, positioning it as a promising therapeutic target for hematological disorders. However, there is a lack of systematic summaries regarding the IGF2BP1 gene within the hematological field. In this review, we provide a comprehensive overview of the discovery and molecular structure of IGF2BP1, along with recent studies on its role in regulating embryogenesis. We also focus on the mechanisms by which IGF2BP1 regulates hematological malignancies through its interactions with its targeted mRNAs. Furthermore, we systematically elucidate the function and mechanism of IGF2BP1 in promoting fetal hemoglobin expression in adult hematopoietic stem/progenitor cells. Finally, we discuss the limitations and challenges of IGF2BP1 as a therapeutic target, offering insights into its prospects.

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LncRNA linc01194 promotes the progress of endometrial carcinoma by up-regulating SOX2 through binding to IGF2BP1

Cited by 4 publications

References 37 publications

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases

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