lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5

Xiu, Yan; Cao, Shengnan; Jiang, Ru; Yang, Zhou

doi:10.1080/21655979.2022.2062536

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…In addition, HAGLR sponges, miR-338-3p, could promote 5-Fu resistance in gastric cancer by targeting the LDHA-glycolysis pathway [ 46 ]. Instead, the overexpression of LINC01315 predicted a worse outcome of triple-negative breast cancer [ 47 ]. Additionally, LncRNA AL161785.1 was used to construct a prognostic model of gastric adenocarcinoma related to glycolysis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Prognosis Risk Model Based on Pyroptosis-Related lncRNAs for Gastric Cancer

Jiang

Fang

2023

Biomolecules

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Gastric cancer (GC) is a malignant tumor with a low survival rate, high recurrence rate, and poor prognosis. With respect to this, pyroptosis is a type of programmed cell death that can affect the occurrence and development of tumors. Indeed, long non-coding RNAs (lncRNAs) were broadly applied for the purposes of early diagnosis, treatment, and prognostic analysis in regard to cancer. Based on the association of these three purposes, we developed a novel prognosis risk model based on pyroptosis-related lncRNAs (PRlncRNAs) for GC. The PRlncRNAs were obtained via univariate and multivariate Cox regression in order to build the predictive signatures. The Kaplan–Meier and gene set enrichment analysis (GSEA) methods were used to evaluate the overall survival (OS) and functional differences between the high- and low-risk groups. Moreover, the correlation of the signatures with immune cell infiltration was determined through single-sample gene set enrichment analysis (ssGSEA). Finally, we analyzed this correlation with the treatment responses in the GC patients; then, we performed quantitative reverse transcription polymerase chain reactions (qRT-PCRs) in order to verify the risk model. The high-risk group received a worse performance in terms of prognosis and OS when compared to the low-risk group. With respect to this, the area under the receiver operating characteristic curve (ROC) was found to be 0.808. Through conducting the GSEA, it was found that the high-risk groups possessed a significant enrichment in terms of tumor–immunity pathways. Furthermore, the ssGSEA revealed that the predictive features possessed strong associations with immune cell infiltration in regard to GC. In addition, we highlighted that anti-immune checkpoint therapy, combined with conventional chemotherapy drugs, may be more suitable for high-risk patients. The expression levels of LINC01315, AP003392.1, AP000695.2, and HAGLR were significantly different between the GC cell lines and the normal cell lines. As such, the six PRlncRNAs could be regarded as important prognostic biomarkers for the purposes of subsequent diagnoses, treatments, prognostic predictions, and the mechanism research of GC.

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Section: Discussionmentioning

confidence: 99%

Prognosis Risk Model Based on Pyroptosis-Related lncRNAs for Gastric Cancer

Jiang

Fang

2023

Biomolecules

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“…Several lncRNAs are aberrantly expressed in breast cancer [21,22]. Dysregulated lncRNAs function as either oncogenes or tumor suppressors to significantly contribute to breast carcinogenesis and progression [23,24]. Therefore, elucidating the roles of dysregulated lncRNAs in breast cancer may help identify novel therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Dong¹,

ZHANG²,

Guan³

et al. 2021

Oncology Research

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Increasing numbers of long noncoding RNAs (lncRNAs) are implicated in breast cancer oncogenicity. However, the contribution of LINC02568 toward breast cancer progression remains unclear and requires further investigation. Herein, we evaluated LINC02568 expression in breast cancer and clarified its effect on disease malignancy. We also investigated the mechanisms underlying the pro-oncogenic role of LINC02568. Consequently, LINC02568 was upregulated in breast cancer samples, with a notable association with worse overall survival. Functionally, depleted LINC02568 suppressed cell proliferation, colony formation, and metastasis, whereas LINC02568 overexpression exerted the opposite effects. Our mechanistic investigations suggested that LINC02568 was physically bound to and sequestered microRNA-874-3p (miR-874-3p). Furthermore, miR-874-3p mediated suppressive effects in breast cancer cells by targeting cyclin E1 (CCNE1).LINC02568 positively controlled CCNE1 expression by sequestering miR-874-3p. Rescue experiments revealed that increased miR-874-3p or decreased CCNE1 expression recovered cell growth and motility functions induced by LINC02568 in breast cancer cells. In conclusion, the tumor-promoting functions of LINC02568 in breast cancer cells were enhanced by sequestering miR-874-3p and consequently over-expressing CCNE1. Our data may facilitate the identification of novel therapeutic targets in clinical settings.

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“…MiRNAs are a class of short ncRNAs with about 22 nucleotides in length that can affect gene expression by mediating mRNA degradation or inhibiting mRNA translation 12 . MiR‐876‐5p has been suggested to function as a tumor‐inhibiting factor in cancers 13–15 . In addition, elevation of miR‐876‐5p has been reported to inhibit EC progression 8,16 .…”

Section: Introductionmentioning

confidence: 99%

“… 12 MiR‐876‐5p has been suggested to function as a tumor‐inhibiting factor in cancers. 13 , 14 , 15 In addition, elevation of miR‐876‐5p has been reported to inhibit EC progression. 8 , 16 Nevertheless, the function of miR‐876‐5p on radiosensitivity in EC has not previously been reported.…”

Section: Introductionmentioning

confidence: 99%

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

Chu,

Sun,

Liu

et al. 2024

Thoracic Cancer

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BackgroundCircular RNAs (circRNAs) play critical roles in the tumorigenesis and radiosensitivity of multiple cancers. Nevertheless, the biological functions of circRNA periostin (circ‐POSTN) in esophageal cancer (EC) progression and radiosensitivity have not been well elucidated.MethodsThe expression of circ‐POSTN, microRNA‐876‐5p (miR‐876‐5p), and proto‐oncogene tyrosine‐protein kinase (FYN) was analyzed by quantitative reverse transcription PCR (RT‐qPCR). Cell proliferation was assessed by MTT, colony formation, and 5‐ethynyl‐2′‐deoxyuridine (EDU) assays. All protein levels were detected by western blot assay. Cell apoptosis and invasion were assessed by flow cytometry analysis and transwell assay, respectively. Dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays were used to validate the interaction between miR‐876‐5p and circ‐POSTN or FYN. The role of circ‐POSTN in vivo was explored by establishing mice xenograft model.ResultsCirc‐POSTN was overexpressed in EC tissues and cells. Knockdown of circ‐POSTN inhibited cell proliferation and invasion and elevated apoptosis and radiosensitivity in EC cells. MiR‐876‐5p was a direct target of circ‐POSTN, and its knockdown reversed the role of sh‐circ‐POSTN in EC cells. FYN was a direct target of miR‐876‐5p, and FYN elevation weakened the effects of miR‐876‐5p overexpression on the progression and radiosensitivity of EC cells. Moreover, circ‐POSTN acted as a miR‐876‐5p sponge to regulate FYN expression. Circ‐POSTN interference also suppressed tumor growth and enhanced radiosensitivity in vivo.ConclusionCirc‐POSTN knockdown inhibited proliferation and invasion, but increased apoptosis and enhanced radiosensitivity in EC cells via modulating miR‐876‐5p/FYN axis, which might be a potential diagnostic and therapeutic target for EC.

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lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5

Cited by 7 publications

References 38 publications

Prognosis Risk Model Based on Pyroptosis-Related lncRNAs for Gastric Cancer

Prognosis Risk Model Based on Pyroptosis-Related lncRNAs for Gastric Cancer

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

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