LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression

Peng, Xing; Gao, Jinyu; Cai, Chunyan; Zhang, Yumei

doi:10.1042/bsr20193371

Cited by 18 publications

(15 citation statements)

References 31 publications

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“…The expression level of LINC01503 in pancreatic cancer was then examined and found that it was significantly upregulated in PAAD. In addition, previous studies identified LINC01503 played an oncogene role in tumors such as colorectal cancer 37 , gastric cancer 38 , glioma 39 , cholangiocarcinoma 40 , and cervical cancer 41 and promotes tumor proliferation and invasion. Therefore, LINC01503 was considered to be the most promising lncRNA that could target and regulate miR-335-5p.…”

Section: Discussionmentioning

confidence: 98%

Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis

Song²,

et al. 2020

BioMed Research International

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Objectives. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) plays a crucial role in modulating extracellular matrix component and promoting tumor progression by changing tumor adhesion, migration, and other biological behaviors in some cancers. However, its expression pattern, biological function, and underlying mechanism in pancreatic cancer remain largely unclear. Materials and Methods. In this study, a set of bioinformatics tools were used to analyze the expression of P4HA1 and its prognostic value in pancreatic cancer. In addition, the mechanism through which P4HA1 promotes the progression of pancreatic cancer was explored by constructing a competing endogenous RNA (ceRNA) regulatory axis. Results. It was found that the mRNA and protein expression of P4HA1 was significantly higher in pancreatic cancer tissues than in normal tissues. Its high P4HA1 expression correlated with poor clinicopathological features (T stage: P = 0.0078 ; N stage: P = 0.0124 ; TNM stage: P = 0.0013 ; pathological grade: P = 0.0108 ) and poor prognosis [OS: HR = 1 , 95% CI (1-1.01), P = 0.00028 ; DSS: HR = 1 , 95% CI (1-1.01), P = 0.00049 ; PFI: HR = 1.01 , 95% CI (1.01-1.02), P = 0.0057 ; and DFI: HR = 1 , 95% CI (1-1.01), P = 0.0034 ]. The LINC01503/miR-335-5p/P4HA1 axis might mediate the effects of P4HA1 in promoting the progression on pancreatic cancer. Conclusions. Collectively, our findings suggest that high expression of P4HA1 may be used as a promising prognostic biomarker and could be considered for the development of a novel therapeutic strategy for pancreatic cancer in the future.

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Section: Discussionmentioning

confidence: 98%

Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis

Song²,

et al. 2020

BioMed Research International

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“…In breast cancer, the SOX9/FXYD3/Src axis is critical for promoting cancer stem cell function and tamoxifen resistance [ 38 ]. In cervical cancer, FXYD3 was confirmed to interact with the LINC01503/miR-342-3p/FXYD3 axis, providing promising therapeutic targets [ 39 ]. Studies have revealed that Na + /K + -ATPase is intimately associated with the EMT as well as the TGF-β1 and NF-κB pathways in malignant tumors [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Expression mode and prognostic value of FXYD family members in colon cancer

Jin

Zhang

Yang³

et al. 2021

Aging

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The FXYD gene family comprises seven members that encode a class of small-membrane proteins characterized by an FXYD motif and interact with Na + /K + -ATPase. Until now, the expression patterns and prognostic roles of the FXYD family in colon cancer (CC) have not been systematically reported. Gene expression, methylation, clinicopathological features and the prognoses of CC patients were obtained from The Cancer Genome Atlas (TCGA) database. The expression feature and prognostic values of FXYD members were identified. Gene set enrichment analysis (GSEA) was performed to explore the potential mechanism underlying the function of the FXYD family in CC. Tumor Immune Estimation Resource (TIMER) and CIBERSORT analysis were used to assess the correlations between FXYD family members and tumor immune infiltrating cells (TIICs). FXYD family members were differentially expressed in CC except for FXYD2. FXYD2, FXYD3 and FXYD4 were revealed as independent prognostic factors for recurrence, while FXYD3 and FXYD7 were identified as prognostic factors for survival according to univariate and multivariate analyses with Cox regression. GSEA revealed that FXYD family members were involved in complicated biological functions underlying cancer progression. TIMER and CIBERSORT analyses showed significant associations between FXYD family genes and TIICs. The present study comprehensively revealed the expression mode and prognostic value of FXYD members in CC, providing insights for further study of the FXYD family as potential clinical biomarkers in CC.

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“…Lu et al found that LINC01503 facilitates progression of colorectal cancer via the miR-4492/ FOXK1 axis 17 . Moreover, Peng et al found that LINC01503 enhances the progression of tumor cells by modulating miR-342-3p /FXYD3 axis in CC 18 . However, the roles of LINC01503 in CC development and progression remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis

Feng¹,

Gao²,

Li³

et al. 2021

J. Cancer

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Mounting evidence indicates that long non-coding RNAs influence the progression of cervical cancer, but the precise function of LINC01503 in the pathogenesis of the disease remains unknown. Here, we found higher levels of LINC01503 in cervical cancer tissues. High LINC01503 expression was associated with enhanced progression of cervical cancer as indicated by advanced FIGO stage, increased metastasis of tumor cells to lymph nodes, and invasion into deeper cervical tissues. LINC01503 inhibition markedly suppressed the invasion and proliferative ability of tumor cells. Mechanistically, LINC01503 was demonstrated to negatively modulate the expression of miR-615-3p in cervical cancer. CCND1 was found to be a target of miR-615-3p. Rescue experiments indicated that LINC01503 inhibition suppressed the invasion and proliferative ability of the tumor cells, a phenomenon that was reversed following miR-615-3p inhibition or CCND1 overexpression. Collectively, these data indicate that LINC01503 enhances the progression of cervical cancer cells via interaction with miR-615-3p/ CCND1 axis.

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LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression

Cited by 18 publications

References 31 publications

Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis

Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis

Expression mode and prognostic value of FXYD family members in colon cancer

Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis

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