LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis

Tang, Congyi; Cai, Yi; Jiang, Huichuan; Lv, Zhengtong; Yang, Chengdong; Xu, Haozhe; Li, Zhi; Li, Yuan

doi:10.18632/aging.104162

Cited by 32 publications

(23 citation statements)

References 35 publications

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“…AC090825.1 and MAGI2-AS3, comprising the gene pair with the highest hazard ratio in the model, were strongly correlated based on RNA expression levels in both paracarcinoma tissues and tumor samples (Supplementary Figure 3 e). Although it has been reported that MAGI2-AS3 could inhibit the development of BCa cells [ 34 ], the interplay between AC090825.1 and MAGI2-AS3 is still unknown. Functional prediction analysis indicated that AC090825.1 and MAGI2-AS3 might regulate their targets, NOX4 and ZEB1 , by interacting with the transcription factors (Supplementary Figure 3 f).…”

Section: Discussionmentioning

confidence: 99%

Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer

et al. 2021

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The tight relationship between ferroptotic cell death and immune response demonstrated by recent studies enlightened us to detect the underlying roles of ferroptosis-related long noncoding RNAs (frlncRNAs) in the tumor microenvironment of bladder cancer (BCa). We collected 121 ferroptosis regulators from previous studies. Based on their expression values, 408 cases with BCa were clustered. The patients in different clusters showed diverse immune infiltration, immunotherapy response, and chemotherapy effectiveness, revalidating the tight correlation with ferroptosis and tumor immunity. Through differential, coexpression, Kaplan-Meier, Lasso, and Cox analysis, we developed a 22-lncRNA-pair signature to predict the prognosis of BCa based on gene-pair strategy, where there is no need for definite expression values. The areas under the curves are all over 0.8. The risk model also helped to predict immune infiltration, immunotherapeutic outcomes, and chemotherapy sensitivity. Totally, the prognostic assessment model indicated a promising predictive value, also providing clues for the interaction between ferroptosis and BCa immunity.

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Section: Discussionmentioning

confidence: 99%

Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer

et al. 2021

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“…All these studies report the downregulation of MAGI2-AS3 during carcinogenesis and support a role of this lncRNA as a tumor suppressor in adrenal, brain, breast, bladder, liver, lung, colorectal, prostate, pancreatic, ovarian, and renal cancers [ 208 , 209 , 210 , 213 , 214 , 217 , 220 , 222 , 223 , 230 , 232 , 234 , 235 , 236 , 237 , 238 , 239 ].…”

Section: Magi Cernas In Carcinogenesismentioning

confidence: 79%

“…Among the putative miRNA targets, miR-200 and miR-143 are considered tumor suppressors in human bladder cancer [ 226 ]. Nevertheless, several studies have demonstrated in this cancer that MAGI2-AS3 was downregulated and negatively associated with tumor stage [ 208 , 213 , 235 ]. In this regard, Wang et al showed that low levels of MAGI2-AS3 were associated with a poor prognosis and that ectopic expression of MAGI2-AS3 inhibited proliferation, migration, and invasion of the human bladder cancer cells T24 and RT4 in vitro, and suppressed the growth of T24 cells in nude mice [ 208 ].…”

Section: Magi Cernas In Carcinogenesismentioning

confidence: 99%

“…Rescue assays demonstrated that knockdown of CCDC19 restored the proliferation, migration, and invasion of bladder cancer cells suppressed by MAGI2-AS3 overexpression [ 208 ]. Tang et al also demonstrated that MAGI2-AS3 upregulates tensin 1 and inhibits the migration and invasion properties of bladder cancer cell lines by quenching miR-31-5p [ 213 ].…”

Section: Magi Cernas In Carcinogenesismentioning

confidence: 99%

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A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer

Kotelevets

Chastre

2021

Cancers

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Scaffolding molecules exert a critical role in orchestrating cellular response through the spatiotemporal assembly of effector proteins as signalosomes. By increasing the efficiency and selectivity of intracellular signaling, these molecules can exert (anti/pro)oncogenic activities. As an archetype of scaffolding proteins with tumor suppressor property, the present review focuses on MAGI1, 2, and 3 (membrane-associated guanylate kinase inverted), a subgroup of the MAGUK protein family, that mediate networks involving receptors, junctional complexes, signaling molecules, and the cytoskeleton. MAGI1, 2, and 3 are comprised of 6 PDZ domains, 2 WW domains, and 1 GUK domain. These 9 protein binding modules allow selective interactions with a wide range of effectors, including the PTEN tumor suppressor, the β-catenin and YAP1 proto-oncogenes, and the regulation of the PI3K/AKT, the Wnt, and the Hippo signaling pathways. The frequent downmodulation of MAGIs in various human malignancies makes these scaffolding molecules and their ligands putative therapeutic targets. Interestingly, MAGI1 and MAGI2 genetic loci generate a series of long non-coding RNAs that act as a tumor promoter or suppressor in a tissue-dependent manner, by selectively sponging some miRNAs or by regulating epigenetic processes. Here, we discuss the different paths followed by the three MAGIs to control carcinogenesis.

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“…ENSG00000233901 (RP11-65J3.1) is a novel lncRNA that only puts forward in this study, and the potential function needs further analysis. ENSG00000234456 (MAGI2-AS3) has been found to be involved in multiple cancers, including esophageal cancer (34), bladder cancer (35), breast cancer (36), and colon adenocarcinoma (37). Compared to other CC-related lncRNA biomarkers (38,39), these four lncRNAs are relatively novel and have good prognostic efficacy.…”

Section: Discussionmentioning

confidence: 99%

N6-Methylandenosine-Related lncRNAs in Tumor Microenvironment Are Potential Prognostic Biomarkers in Colon Cancer

Zhang

Zhao²,

Li³

et al. 2021

Front. Oncol.

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BackgroundLncRNA dysregulation and the tumor microenvironment (TME) have been shown to play a vital role in the progression and prognosis of colon cancer (CC). We aim to reveal the potential molecular mechanism from the perspective of lncRNA in the TME and provide the candidate biomarkers for CC prognosis.MethodsESTIMATE analysis was used to divide the CC patients into high and low immune or stromal score groups. The expression array of lncRNA was re-annotated by Seqmap. Microenvironment-associated lncRNAs were filtered through differential analysis. The m6A-associated lncRNAs were screened by Pearson correlation analysis. Lasso Cox regression analyses were performed to construct the m6A- and tumor microenvironment-related lncRNA prognostic model (m6A-TME-LM). Survival analysis was used to assess the prognostic efficacy of candidate lncRNAs. Enrichment analyses annotated the candidate genes’ functions.ResultsWe obtained 25 common differentially expressed lncRNAs (DELs) associated with immune microenvironment and m6A-related genes for subsequent lasso analysis. Four out of these DELs were selected for the m6A-TME-LM. All the four lncRNAs were related to overall survival, and a test set testified the result. Further stratification analysis of the m6A-TME-LM retained its ability to predict OS for male and chemotherapy adjuvant patients and performed an excellent prognostic efficacy in the TNM stage III and IV subgroups. Network analysis also found the four lncRNAs mediated co-expression network was associated with tumor development.ConclusionWe constructed the m6A-TME-LM, which could provide a better prognostic prediction of CC.

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LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis

Cited by 32 publications

References 35 publications

Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer

Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer

A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer

N6-Methylandenosine-Related lncRNAs in Tumor Microenvironment Are Potential Prognostic Biomarkers in Colon Cancer

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