LncRNA MALAT1 acts as a miR-125a-3p sponge to regulate FOXM1 expression and promote hepatocellular carcinoma progression

Liu, Shihai; Qiu, Jing; He, Guifang; Liang, Ye; Wang, Liping; Liu, Changchang; Pan, Huazheng

doi:10.7150/jca.29213

Cited by 47 publications

(46 citation statements)

References 31 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence indicates that lncRNAs serve as a sponge to negatively regulate certain miRNAs. 16,17 To investigate whether lncRNA HOXA-AS3 utilizes a similar mechanism, bioinformatics software (StarBase v2.0) was used to identify lncRNA HOXA-AS3 binding sites ( Figure 4A,B). Luciferase activity analysis showed that compared with the blank vector control, the lncRNA HOXA-AS3 level of miR-455-5p overexpression group was significantly reduced by 51% ( Figure 4C).…”

Section: Lncrna Hoxa-as3 Acts As a Mirna Sponge And Negatively Regumentioning

confidence: 99%

LncRNA HOXA‐AS3 promotes the malignancy of glioblastoma through regulating miR‐455‐5p/USP3 axis

Chen

Zhang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is a fast-growing type of aggressive and lethal primary brain tumour. 1,2 Because the pathologic mechanisms of GBM are not fully understood, more research is needed to identify effective predictive biomarkers and therapeutic targets for GBM. 2,3 Emerging studies, supported by whole-genome sequencing technology and microarray assays, have shown long non-coding RNAs (lncRNAs) to be key regulatory transcripts. 4 LncRNAs are classified

show abstract

Section: Lncrna Hoxa-as3 Acts As a Mirna Sponge And Negatively Regumentioning

confidence: 99%

LncRNA HOXA‐AS3 promotes the malignancy of glioblastoma through regulating miR‐455‐5p/USP3 axis

Chen

Zhang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Interestingly, lncRNA MALAT1, locating on human chromosome 11q13.1 with a transcript sequence of approximately 8 kb, is a context‐specific lncRNA among mammals that involved in the development of diverse malignancies by crosstalk with Hippo pathway 74‐80 . Early studies consistently showed that MALAT1 is highly expressed in cancerous tissue and facilitates tumour progression and metastasis in various cancers.…”

Section: Regulatory Network Of Lncrnas and Hippo Signalling Pathway Imentioning

confidence: 99%

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Yang

Lü

et al. 2020

Cell Proliferation

View full text Add to dashboard Cite

LncRNAs play a pivotal role in the regulation of epigenetic modification, cell cycle, differentiation, proliferation, migration and other physiological activities. In particular, considerable studies have shown that the aberrant expression and dysregulation of lncRNAs are widely implicated in cancer initiation and progression by acting as tumour promoters or suppressors. Hippo signalling pathway has attracted researchers’ attention as one of the critical cancer‐related pathways in recent years. Increasing evidences have demonstrated that lncRNAs could interact with Hippo cascade and thereby contribute to acquisition of multiple malignant hallmarks, including proliferation, metastasis, relapse and resistance to anti‐cancer treatment. Specifically, Hippo signalling pathway is reported to modulate or be regulated by widespread lncRNAs. Intriguingly, certain lncRNAs could form a reciprocal feedback loop with Hippo signalling. More speculatively, lncRNAs related to Hippo pathway have been poised to become important putative biomarkers and therapeutic targets in human cancers. Herein, this review focuses on the crosstalk between lncRNAs and Hippo pathway in carcinogenesis, summarizes the comprehensive role of Hippo‐related lncRNAs in tumour progression and depicts their clinical diagnostic, prognostic or therapeutic potentials in tumours.

show abstract

“…Accumulating evidences have shown that lncRNAs are closely associate with the occurrence and progression of malignancies and tumor drug resistance, which are served as tumor hallmarks. [11][12][13] For instance, lncRNA metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has been reported to promote proliferation and metastasis in epithelial ovarian cancer, 14 hepatocellular carcinoma 15 and colorectal cancer. 16 Through literature review, we concluded that MALAT1 is involved in regulating proliferation, apoptosis, differentiation and metastasis of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…16 Through literature review, we concluded that MALAT1 is involved in regulating proliferation, apoptosis, differentiation and metastasis of tumor cells. [14][15][16] The specific role of MALAT1 in GC still needs to be further investigated.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA MALAT1 Regulates the Cell Proliferation and Cisplatin Resistance in Gastric Cancer via PI3K/AKT Pathway</p>

Dai¹,

Zhang²,

Li³

2020

CMAR

View full text Add to dashboard Cite

Background: Many studies showed that long non-coding RNA MALAT1 is served as an oncogene. However, the specific role of MALAT1 in gastric cancer is not fully elucidated. The aim of this study is to elucidate the regulatory effects of MALAT1 on tumor development and cisplatin resistance in gastric cancer. Methods: TCGA database was applied to investigate the expression levels of MALAT1 in GC tissues and normal gastric tissues and its correlation with GC patients' survival. Univariate and multivariate analysis were performed to investigate whether MALAT1 expression is an independent risk for overall survival of gastric cancer patients. The expression of MALAT1 was detected by Quantitative real-time PCR. After knockdown or overexpression of MALAT1, the cellular functions of GC cells were detected by cell-proliferation, flow cytometry, transwell assay and colony formation assays, respectively. Western blot analysis was performed to detect the protein levels of Bcl-2 and key genes in the PI3K/AKT pathway in GC cells. Finally, CCK-8 assay was performed to explore the effect of MALAT1 on cisplatin resistance of GC cells. Results: Higher expression of MALAT1 was detected in GC tissues than that of adjacent normal tissues, high MALAT1 expression is an independent risk for overall survival of gastric cancer patients. Knockdown of MALAT1 inhibited proliferation, migration and invasion of GC cells, while overexpression of MALAT1 Overexpression of MALAT1 yielded opposite results. Western blot results showed that protein expressions of p-PI3K, p-AKT and p-STAT3 were downregulated after MALAT1 knockdown in GC cells, while these proteins were upregulated after MALAT1 overexpression. Additionally, the IC 50 in MGC803/CDDP cells transfected with si-MALAT1 was lower than in those transfected with si-NC. The apoptotic rate in MGC803 cells transfected with pcDNA-MALAT1 was remarkably lower than those transfected with NC. Conclusion: We demonstrated that MALAT1 is highly expressed in GC, high MALAT1 expression is an independent risk factor for OS among GC patients. Moreover, MALAT1 promotes malignant progression of GC and contributes to cisplatin resistance of GC cells, indicating MALAT1 may serve as a biological hallmark for predicting the prognosis of GC.

show abstract

LncRNA MALAT1 acts as a miR-125a-3p sponge to regulate FOXM1 expression and promote hepatocellular carcinoma progression

Cited by 47 publications

References 31 publications

LncRNA HOXA‐AS3 promotes the malignancy of glioblastoma through regulating miR‐455‐5p/USP3 axis

LncRNA HOXA‐AS3 promotes the malignancy of glioblastoma through regulating miR‐455‐5p/USP3 axis

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

<p>LncRNA MALAT1 Regulates the Cell Proliferation and Cisplatin Resistance in Gastric Cancer via PI3K/AKT Pathway</p>

Contact Info

Product

Resources

About