2021
DOI: 10.1016/j.cyto.2021.155657
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LncRNA MEG3 suppresses PI3K/AKT/mTOR signalling pathway to enhance autophagy and inhibit inflammation in TNF-α-treated keratinocytes and psoriatic mice

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Cited by 62 publications
(36 citation statements)
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“…MEG3 suppressed keratinocyte proliferation and accelerated cell apoptosis by targeting miR-21 and increasing the expression of Caspase 8 [ 126 ]. Furthermore, MEG3 inhibited keratinocyte inflammatory response and enhanced autophagy via PI3K/AKT/mTOR signaling pathway in vitro or in vivo [ 127 ].…”
Section: Factors Regulating Psoriatic Keratinocytesmentioning
confidence: 99%
“…MEG3 suppressed keratinocyte proliferation and accelerated cell apoptosis by targeting miR-21 and increasing the expression of Caspase 8 [ 126 ]. Furthermore, MEG3 inhibited keratinocyte inflammatory response and enhanced autophagy via PI3K/AKT/mTOR signaling pathway in vitro or in vivo [ 127 ].…”
Section: Factors Regulating Psoriatic Keratinocytesmentioning
confidence: 99%
“…A combination of cytokines (IL-1β, TNF-α, and IL-17A) was also shown to activate the mTORC1 signaling axis. The LncRNA maternally expressed gene 3 (MEG3) has been shown to enhance autophagy and suppress inflammation in TNF-α-treated keratinocytes and psoriatic mice via the PI3K/AKT/mTOR pathway [35]. Moreover, several deregulated miRNAs were demonstrated to activate the mTOR pathway in psoriatic skin [36,37], along with mechanosensitive molecules such as polycystins (Figure 2) [38].…”
Section: Mtor Signaling In Psoriasismentioning
confidence: 99%
“…Further, mTOR activation promotes neurotrophic factor-3 expression to induce the regeneration of myelinated axons ( 56 ). The abnormal activation or inhibition of the PI3K/Akt/mTOR can cause cancer, immunity, aging, metabolism, and other diseases ( 57 60 ). Considering the aforementioned studies, an in-depth investigation of the mTOR pathway can open avenues in understanding its upstream and downstream mechanisms, as well as its regulation that can be translated to improve neurological conditions.…”
Section: The Mtor Signaling Pathwaymentioning
confidence: 99%