2021
DOI: 10.1038/s10038-021-00993-z
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LncRNA-mRNA co-expression network revealing the regulatory roles of lncRNAs in melanogenesis in vitiligo

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Cited by 8 publications
(4 citation statements)
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“…Previous studies reported that PMEL, also known as Pmel-17 or gp100, plays a crucial role in vertebrate pigmentation. Du et al identified that the transcription of MLANA and PMEL is regulated by MITF in both melanocytes and melanoma [39,40]. The OCA gene is crucial in oculocutaneous albinism (OCA), a rare disorder marked by reduced melanin biosynthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies reported that PMEL, also known as Pmel-17 or gp100, plays a crucial role in vertebrate pigmentation. Du et al identified that the transcription of MLANA and PMEL is regulated by MITF in both melanocytes and melanoma [39,40]. The OCA gene is crucial in oculocutaneous albinism (OCA), a rare disorder marked by reduced melanin biosynthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, several studies have investigated the aberrant expression of lncRNAs in the pathogenesis of vitiligo using samples from skin biopsies, serum, or peripheral blood mononuclear cells (PBMCs). These aberrantly expressed lncRNAs can participate in the pathogenesis of vitiligo by affecting interleukin-(IL-) 17 production, oxidative stress-mediated melanocyte injury, and the regulation of melanogenesis-related genes [10][11][12][13][14][15][16]. However, no studies have focused on the potential aberrantly expressed lncRNAs in T cells from patients with vitiligo.…”
Section: Introductionmentioning
confidence: 99%
“…It is defined by white macular formation that results from the loss of epidermal melanocytes [1]. The etiological factors involved in the depigmentation process of vitiligo include immunological dysfunction, neurotoxic factor destruction, and genetic predisposition [2]. Various research indicates that the etiology and progression of vitiligo are affected by multiple polygenic factors.…”
mentioning
confidence: 99%