LncRNA-NEAT1 inhibits the occurrence and development of pancreatic cancer through spongy miR-146b-5p/traf6

Wei, Feifei; Yan, Zhiying; Zhang, Xianming; Wang, Yaoyao; Wang, MiaoJing; Zhu, Yingwei; Xu, Kequn

doi:10.1080/02648725.2023.2192059

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…However, with the deepening of understanding, it has been found that LncRNAs are widely distributed in eukaryotes and participate in various important biological functions, including the regulation of autophagy [8], speci c transcriptional and posttranscriptional controls [9], transduction of intermolecular signals [10], and regulation of protein stability after translation [11]. In the research of cancer, LncRNAs are differentially expressed in prostate cancer, breast cancer, colorectal cancer, pancreatic cancer, non-small cell lung cancer, hepatocellular carcinoma and so on, and play an important role in the proliferation, migration and invasion of tumor cells [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Identification and Validation of a m5c-related lncrna signature predict prognosis and immune response of clear cell renal cell carcinoma

Liang

Yang

et al. 2023

Preprint

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Objective M5C-related LncRNAs (Long non-coding RNAs) were related to the occurrence and development of tumors. In this study, we investigated whether m5C-related LncRNAs could predict the prognosis of clear cell renal cell carcinoma (ccRCC) patients. Methods Co-expression analysis and Cox regression analysis were used to construct prognostic features, and then a series of model validation was performed to evaluate the prognostic value of the model. Gene Ontology (GO), Kyoto Encyclopedia of Gene and Genome Enrichment (KEGG), immune-related function and tumor mutation burden (TMB) analyses were also performed. Finally, the potential sensitivity of drugs to ccRCC was predicted. Results A total of 9 m5C-related LncRNAs were obtained and a prognostic model was established. Our model has independent prognostic value and is closely related to tumor immune characteristics and immune escape, which can be used to predict the sensitivity of drugs including Entinostat, SB216763, and Sapitinib. Our in vitro experiments showed that GNG12-AS1 inhibited cell proliferation and migration in ccRCC cell lines. Conclusions In summary, the 9 m5C-related LncRNAs can accurately predict the prognosis of ccRCC patients, which may provide new ideas for clinical application and immunotherapy of ccRCC patients, and GNG12-AS1 is a promising prognostic biomarker for predicting survival outcome of ccRCC.

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Section: Introductionmentioning

confidence: 99%

Identification and Validation of a m5c-related lncrna signature predict prognosis and immune response of clear cell renal cell carcinoma

Liang

Yang

et al. 2023

Preprint

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The Expanding Roles of Long Non‐Coding RNAs in Pancreatic Cancer

Yan,

Wu,

Yang

et al. 2023

Advanced Therapeutics

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Pancreatic cancer is a clinically challenging disease with a poor survival rate and is one of the leading causes of cancer‐related morbidity. It is highly resistant to treatment and effective diagnostic tools during the early stages of the disease are lacking. Long non‐coding RNAs (lncRNAs) participate extensively in the physiological processes of various diseases, especially multiple types of cancers. lncRNAs have been shown to perform essential functions and are gaining increasing attention in pancreatic cancer research. This review summarizes the roles of lncRNAs in the occurrence, development, and therapeutic resistance of pancreatic cancer by categorizing their regulation of epigenetic inheritance, transcription, post‐transcription, and related signaling pathways. Potential clinical implications, including diagnostic and prognostic biomarkers, as well as the therapeutic prospects of these lncRNAs in pancreatic cancer, are also discussed. Novel insights into the role of lncRNAs in the pathogenesis of pancreatic cancer may help researchers develop novel therapeutic strategies.This article is protected by copyright. All rights reserved

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LncRNA NEAT1 promotes proliferation, migration, and invasion of laryngeal squamous cell carcinoma cells through miR-411-3p/FZD3-mediated Wnt signaling pathway

Liang,

Fang,

Gao

et al. 2024

BMC Cancer

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The lncRNA NEAT1 has been shown to promote the progression of several cancers, containing laryngeal squamous cell carcinoma (LSCC). However, the precise mechanism by which it promotes LSCC progression remains unclear. In this study, we verified the high expression of lncRNA NEAT1 in LSCC tissues and cells using RT-qPCR. Analysis of clinical data exhibited that high expression of lncRNA NEAT1 was associated with a history of smoking, worse T stage, lymph node metastasis, and later TNM stage in patients with LSCC. The promotion effect of lncRNA NEAT1 on LSCC cell proliferation, migration, invasion, and tumor growth in vivo was verified by CCK-8, plate clone formation, Transwell, and nude mouse tumorigenicity assays. Bioinformatics prediction and double luciferase reporter gene assay verified the binding of miR-411-3p to lncRNA NEAT1 and FZD3 mRNA, and inhibition of miR-411-3p reversed the inhibitory effect of lncRNA NEAT1 on FZD3 expression in LSCC cells. We also verified that lncRNA NEAT1-mediated FZD3 activation in the Wnt pathway affects LSCC development. In conclusion, we demonstrate that lncRNA NEAT1 promotes the progression of LSCC, and propose that the lncRNA NEAT1/miR-411-3p/FZD3 axis may be an effective target for LSCC therapy.

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LncRNA-NEAT1 inhibits the occurrence and development of pancreatic cancer through spongy miR-146b-5p/traf6

Cited by 5 publications

References 19 publications

Identification and Validation of a m5c-related lncrna signature predict prognosis and immune response of clear cell renal cell carcinoma

Identification and Validation of a m5c-related lncrna signature predict prognosis and immune response of clear cell renal cell carcinoma

The Expanding Roles of Long Non‐Coding RNAs in Pancreatic Cancer

LncRNA NEAT1 promotes proliferation, migration, and invasion of laryngeal squamous cell carcinoma cells through miR-411-3p/FZD3-mediated Wnt signaling pathway

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