LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1

Li, Yabin; Wang, Xirui; Zhao, Zhihuang; Shang, Jinxing; Li, Gang; Zhang, Ruijian

doi:10.1042/bsr20200767

Cited by 29 publications

(21 citation statements)

References 56 publications

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“…Accumulating reports indicate that lncRNA NEAT1 works as a sponge for miR-98, downregulating its levels in lung cancer and colon cancer cells ( 15 , 24 – 26 ). Therefore, we postulated that NEAT1 would sponge miR-98 in EC cells.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, MRP-7 could be a useful diagnostic and prognostic biomarker, as well as a therapeutic target for EC. The tumor suppressor capability of miR-98 has been demonstrated in numerous human malignancies (15,16), where it negatively regulates cancer cell growth, migration, and invasion. The downregulation of miR-98 has been linked to cisplatin resistance in lung cancer (17).…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulation of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) has recently been discovered to have a key role in carcinogenesis, tumor development, and chemoresistance in a variety of malignancies, including EC ( 13 , 14 ). MiR-98, for example, has been discovered to suppress the malignant phenotypes in glioma and lung cancer ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

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A Novel miR-98 Negatively Regulates the Resistance of Endometrial Cancer Cells to Paclitaxel by Suppressing ABCC10/MRP-7

et al. 2021

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Endometrial cancer (EC) is one of the most frequent gynecological tumors, and chemoresistance is a major obstacle to improving the prognosis of EC patients. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have recently emerged as crucial chemoresistance regulators that alter the levels of downstream target genes. Multidrug Resistance Protein 7 (MRP-7/ABCC10) is an ATP-binding cassette transporter that causes the resistance to anti-cancer drugs. The purpose of this research is to determine whether MRP-7 has a role in mediating the sensitivity of EC cells to paclitaxel and whether the expression of MRP-7 is regulated by miR-98 and lncRNA NEAT1. We reported that the levels of MRP-7 were significantly increased in EC tissues and associated with an unfavorable prognosis. Downregulation of MRP-7 in EC cells sensitized these cells to paclitaxel and reduced cell invasion. PLAUR serves as a downstream molecule of MRP-7 and facilitates paclitaxel resistance and EC cell invasiveness. Moreover, miR-98 serves as a tumor suppressor to inhibit MRP-7 expression, leading to the repression of paclitaxel resistance. Furthermore, a novel lncRNA, NEAT1, was identified as a suppressor of miR-98, and NEAT1 could upregulate MRP-7 levels by reducing the expression of miR-98. Taken together, these findings demonstrate that upregulation of MRP-7 and NEAT1, and downregulation of miR-98 have important roles in conferring paclitaxel resistance to EC cells. The modulation of these molecules may help overcome the chemoresistance against paclitaxel in EC cells.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel miR-98 Negatively Regulates the Resistance of Endometrial Cancer Cells to Paclitaxel by Suppressing ABCC10/MRP-7

et al. 2021

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“…Multiple studies reported increased expression and an oncogenic effect for NEAT1 in glioma (147)(148)(149)(150)(151)(152)(153)(154)(155)(156)(157)(158)(159)(160). NEAT1 increased the activity of several signaling pathways with key roles in the cell cycle, including WNT/b-Catenin and mTOR signaling, leading to increased proliferation, invasion, and metastasis and decreased apoptosis.…”

Section: Role In Tumor Pathologymentioning

confidence: 99%

“…In-vivo therapeutic applications : For many oncogenic lncRNAs, including XIST ( 164 , 169 , 171 ), NEAT1 ( 150 , 158 ), CRNDE ( 173 , 175 , 176 ), TUG1 ( 182 , 183 ), FOXD2-AS1 ( 190 ), HOXA11-AS ( 199 , 201 ), and TP73-AS1 ( 204 , 208 ), and tumor suppressor lncRNAs, including GAS5 ( 214 , 215 ), CASC2 ( 221 ), MATN1-AS1 ( 226 ), animal studies, which are more advanced stages of investigating roles of lncRNAs ( 255 ), validated their effect on glioma. Furthermore, lncRNAs can mediate the effects of anti-cancer drugs.…”

Section: Lncrnas In Gliomamentioning

confidence: 99%

Long Non-Coding RNAs in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-of-the-Art Review

Momtazmanesh

Rezaei

2021

Front. Oncol.

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Glioma is the most common malignant central nervous system tumor with significant mortality and morbidity. Despite considerable advances, the exact molecular pathways involved in tumor progression are not fully elucidated, and patients commonly face a poor prognosis. Long non-coding RNAs (lncRNAs) have recently drawn extra attention for their potential roles in different types of cancer as well as non-malignant diseases. More than 200 lncRNAs have been reported to be associated with glioma. We aimed to assess the roles of the most investigated lncRNAs in different stages of tumor progression and the mediating molecular pathways in addition to their clinical applications. lncRNAs are involved in different stages of tumor formation, invasion, and progression, including regulating the cell cycle, apoptosis, autophagy, epithelial-to-mesenchymal transition, tumor stemness, angiogenesis, the integrity of the blood-tumor-brain barrier, tumor metabolism, and immunological responses. The well-known oncogenic lncRNAs, which are upregulated in glioma, are H19, HOTAIR, PVT1, UCA1, XIST, CRNDE, FOXD2-AS1, ANRIL, HOXA11-AS, TP73-AS1, and DANCR. On the other hand, MEG3, GAS5, CCASC2, and TUSC7 are tumor suppressor lncRNAs, which are downregulated. While most studies reported oncogenic effects for MALAT1, TUG1, and NEAT1, there are some controversies regarding these lncRNAs. Expression levels of lncRNAs can be associated with tumor grade, survival, treatment response (chemotherapy drugs or radiotherapy), and overall prognosis. Moreover, circulatory levels of lncRNAs, such as MALAT1, H19, HOTAIR, NEAT1, TUG1, GAS5, LINK-A, and TUSC7, can provide non-invasive diagnostic and prognostic tools. Modulation of expression of lncRNAs using antisense oligonucleotides can lead to novel therapeutics. Notably, a profound understanding of the underlying molecular pathways involved in the function of lncRNAs is required to develop novel therapeutic targets. More investigations with large sample sizes and increased focus on in-vivo models are required to expand our understanding of the potential roles and application of lncRNAs in glioma.

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Exosomal lncRNA HEIH, an essential communicator for hepatocellular carcinoma cells and macrophage M2 polarization through the miR‐98‐5p/STAT3 axis

Ai,

Wen,

Dai

et al. 2024

J Biochem & Molecular Tox

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Part of human long noncoding RNAs (lncRNAs) has been elucidated to play an essential role in the carcinogenesis and progression of hepatocellular carcinoma (HCC), a type of malignant tumor with poor outcomes. Tumor‐derived exosomes harboring lncRNAs have also been implicated as crucial mediators to orchestrate biological functions among neighbor tumor cells. The recruitment of tumor‐associated macrophages (TAMs) exerting M2‐like phenotype usually indicates the poor prognosis. Yet, the precise involvement of tumor‐derived lncRNAs in cross‐talk with environmental macrophages has not been fully identified. In this study, we reported the aberrantly overexpressed HCC upregulated EZH2‐associated lncRNA (HEIH) in tumor tissues and cell lines was positively correlated with poor prognosis, as well as enriched exosomal HEIH levels in blood plasma and cell supernatants. Besides, HCC cell‐derived exosomes transported HEIH into macrophages for triggering macrophage M2 polarization, thereby in turn promoting the proliferation, migration, and invasion of HCC cells. Mechanistically, HEIH acted as a miRNA sponge for miR‐98‐5p to up‐regulate STAT3, which was then further verified in the tumor xenograft models. Collectively, our study provides the evidence for recognizing tumor‐derived exosomal lncRNA HEIH as a novel regulatory function through targeting miR‐98‐5p/STAT3 axis in environmental macrophages, which may shed light on the complicated tumor microenvironment among tumor and immune cells for HCC treatment.

show abstract

LncRNA NEAT1 promotes glioma cancer progression via regulation of miR-98-5p/BZW1

Cited by 29 publications

References 56 publications

A Novel miR-98 Negatively Regulates the Resistance of Endometrial Cancer Cells to Paclitaxel by Suppressing ABCC10/MRP-7

A Novel miR-98 Negatively Regulates the Resistance of Endometrial Cancer Cells to Paclitaxel by Suppressing ABCC10/MRP-7

Long Non-Coding RNAs in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-of-the-Art Review

Exosomal lncRNA HEIH, an essential communicator for hepatocellular carcinoma cells and macrophage M2 polarization through the miR‐98‐5p/STAT3 axis

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