LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer

Zhang, Zilang; Ye, B. Hilda; Lin, Yiban; Liu, Wenjun; Deng, Jianzhong; Wu, Jiahui

doi:10.1007/s12094-023-03193-7

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…Zhang et al reported that the expression of HEPFAL in HCC was significantly reduced, and HCC cells with lower HEPFAL expression had greater invasion and migration abilities. Overexpression of HEPFAL in HCC cells increased the intracellular Fe 2+ and ROS levels and the sensitivity of HCC cells to erastin-induced ferroptosis (63). Mechanistically, HEPFAL overexpression led to the ubiquitination of SLC7A11, reducing its stability and half-life, but had no significant effect on FSP1.…”

Section: Ferroptosis-related Lncrnas and Hccmentioning

confidence: 94%

“…The lncRNA T-UCR Uc.339 was shown to inhibit miR-339 and promote SLC7A11 expression, also promoting lung adenocarcinoma growth and metastasis (62). The lncRNA HEPFAL can regulate the ubiquitination of SLC7A11 and affect its function (63). The lncRNA double homeobox A pseudogene 8 (DUXAP8) can regulate SLC7A11 palmitoylation and protect HCC cells (64).…”

Section: Lncrnas and The Ferroptosis Defense Systemmentioning

confidence: 99%

“…The lncRNA double homeobox A pseudogene 8 (DUXAP8) can regulate SLC7A11 palmitoylation and protect HCC cells ( 64 ). The lncRNA ovarian tumor domain containing 6B antisense RNA1 (OTUD6B-AS1) can promote GPX4-mediated ferroptosis and increase the radiosensitivity of colorectal cancer cells ( 65 ). The lncRNA LINC01134 inhibits ferroptosis and promotes oxaliplatin resistance of HCC by promoting Nrf2-GPX4 binding ( 66 ).…”

Section: Lncrnas and Ferroptosismentioning

confidence: 99%

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Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

Chen,

Han,

et al. 2024

Front. Immunol.

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Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to the medical community because of its high mortality rate. In recent years, ferroptosis, a unique form of cell death, has garnered widespread attention. Ferroptosis, which is characterized by iron-dependent lipid peroxidation and mitochondrial alterations, is closely associated with the pathological processes of various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are a type of functional RNA, and play crucial regulatory roles in a variety of biological processes. In this manuscript, we review the regulatory roles of lncRNAs in the key aspects of ferroptosis, and summarize the research progress on ferroptosis-related lncRNAs in hepatocellular carcinoma.

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Section: Ferroptosis-related Lncrnas and Hccmentioning

confidence: 94%

Section: Lncrnas and The Ferroptosis Defense Systemmentioning

confidence: 99%

Section: Lncrnas and Ferroptosismentioning

confidence: 99%

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Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

Chen,

Han,

et al. 2024

Front. Immunol.

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“…Additionally, GPX4 prevents ferroptosis, making it a potential target for therapeutic interventions, including cancer treatment ( Forcina and Dixon, 2019 ). Due to frequent m6A and m5c modification of GPX4 in CRC, it is highly overexpressed ( Chen B. et al, 2023 ; Zhang G. et al, 2023 ), leading to anti-cancer immunity ( Chen B. et al, 2023 ), radiation resistance ( Zhang et al, 2023c ), and chemoresistance ( Wang L. et al, 2023 ). The increased presence of GPX4 is detected in CRC persister cells resulting from exposure to anti-colorectal cancer drugs like 5-FU and AZ628.…”

Section: Natural Products Targeting System XC − /G...mentioning

confidence: 99%

Targeting ferroptosis regulators by natural products in colorectal cancer

Zhang,

Xie

2024

Front. Pharmacol.

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Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed cancer and the second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such as delayed diagnosis, multidrug resistance, and limited therapeutic effectiveness persist, emphasizing the need for innovative approaches. This review explores the potential of natural products, nutraceuticals, and phytochemicals for targeting ferroptosis-related regulators as a novel strategy in CRC. Ferroptosis, a form of regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance in CRC progression and therapy resistance. Natural products, known for their diverse bioactive effects and favorable safety profiles, emerge as promising candidates to induce ferroptosis in CRC cells. Exploring amino acid, iron, lipid metabolism regulators, and oxidative stress regulators reveals promising avenues for inducing cell death in CRC. This comprehensive review provides insights into the multifaceted effects of natural products on proteins integral to ferroptosis regulation, including GPX4, SLC7A11, ACSL4, NCOA4, and HO-1. By elucidating the intricate mechanisms through which natural products modulate these proteins, this review lays the foundation for a promising therapeutic strategy in CRC.

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“…Zhang et al. reported that overexpression of OTUD6B-AS1 by binding with HuR stabilizes TRIM16 and increases iron accumulation mediated by GPX4, thus weakening CRC’s radioresistance ( 170 ). Another study indicated that exosomal SNHG11 is upregulated in bevacizumab-resistant CRC cells, and SNHG11 contributes to the resistance to bevacizumab in CRC, depending on the regulation of miR-1207-5p and ABCC1 ( 184 ).…”

Section: Lncrnas Regulate Drug Resistancementioning

confidence: 99%

The functions and mechanisms of long non-coding RNA in colorectal cancer

Lin,

Zhao,

et al. 2024

Front. Oncol.

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CRC poses a significant challenge in the global health domain, with a high number of deaths attributed to this disease annually. If CRC is detected only in its advanced stages, the difficulty of treatment increases significantly. Therefore, biomarkers for the early detection of CRC play a crucial role in improving patient outcomes and increasing survival rates. The development of a reliable biomarker for early detection of CRC is particularly important for timely diagnosis and treatment. However, current methods for CRC detection, such as endoscopic examination, blood, and stool tests, have certain limitations and often only detect cases in the late stages. To overcome these constraints, researchers have turned their attention to molecular biomarkers, which are considered a promising approach to improving CRC detection. Non-invasive methods using biomarkers such as mRNA, circulating cell-free DNA, microRNA, LncRNA, and proteins can provide more reliable diagnostic information. These biomarkers can be found in blood, tissue, stool, and volatile organic compounds. Identifying molecular biomarkers with high sensitivity and specificity for the early and safe, economic, and easily measurable detection of CRC remains a significant challenge for researchers.

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LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer

Cited by 9 publications

References 51 publications

Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

Targeting ferroptosis regulators by natural products in colorectal cancer

The functions and mechanisms of long non-coding RNA in colorectal cancer

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