LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis

Gao, Fangyuan; Feng, Jing; Yao, Hairong; Li, Yanying; Xi, Jie; Yang, Jun

doi:10.1080/21691401.2019.1577883

Cited by 66 publications

(65 citation statements)

References 22 publications

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“…For example, lncRNA SOX21-AS1 accelerates CC development by sponging miR-7 and targeting VDAC1 [15]. LncRNA SBF2-AS1 contributes to the development of CC by modulating the miR-361-5p/FOXM1 axis [16]. LncRNA RP11-552M11.4 is conducive to oncogenesis and development of CC through regulating miR-3941/ATF1 signaling pathway [17].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis

Liang

Zhang

Wang³

et al. 2020

Bioscience Reports

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Cervical cancer (CC) is ranked as the fourth most common cancer that occurs in women universally, which normally causes pain in the lower belly. Plenty of studies have stated that the expression of long non-coding RNAs (lncRNAs) is linked to the cellular development of many kinds of cancers. DSCAM-AS1 has been reported to act as an oncogene in other cancer types and the aim of our study was to uncover the function and regulatory mechanism of DSCAM-AS1 in CC. In this research, our findings presented that DSCAM-AS1 expression was up-regulated in CC cells. DSCAM-AS1 led to the development of CC by enhancing cell proliferation, migration and invasion ability. DSCAM-AS1 was verified to combine with miR-877-5p and down-regulate the expression of miR-877-5p. Results also showed that ATXN7L3 was a downstream target gene of miR-877-5p and it was unfavorably modulated by miR-877-5p. Enhanced expression of ATXN7L3 counterbalanced the DSCAM-AS1 knockdown effect on the progression of CC. This was the first time to analyze the underlying regulatory mechanism of the oncogenic DSCAM-AS1. Our findings clarified that DSCAM-AS1 played as an oncogenic lncRNA by targeting miR-877-5p/ATXN7L3 axis to promote CC progression, which may provide insights into the prevention of CC.

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis

Liang

Zhang

Wang³

et al. 2020

Bioscience Reports

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“…Briefly, the logarithmically growing cells (1 Â 10 4 /well) were inoculated into 96-well culture plates and cultured for indicated times. Then 10 lL CCK-8 solutions were added and incubated for 2 h at 37 C. Absorbance at 450 nm was measured using a microtiter plate reader (Bio-Rad, CA) [13].…”

Section: Cell Proliferation Assaymentioning

confidence: 99%

“…SBF2-AS1 is a 2708 nt antisense RNA to SBF2, which is located at the 11p15.1 locus [11]. Recent studies showed that SBF2-AS1 might play critical roles in tumor progression, such as lung cancer, cervical cancer, esophageal squamous cell carcinoma, and liver cancer [12][13][14][15]. However, the roles and underlying mechanisms of SBF2-AS1 in AML remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SBF2-AS1 act as a ceRNA to modulate cell proliferation via binding with miR-188-5p in acute myeloid leukemia

Tian

Wang

Xiao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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LncRNA SBF2-AS1 has been reported to be implicated in the deterioration of multiple human cancers. However, the roles and underlying mechanisms of SBF2-AS1 in acute myeloid leukemia (AML) are still unclear. In the present study, the online GEPIA database showed that SBF2-AS1 expression was significantly increased in AML samples. QRT-PCR results showed that SBF2-AS1 expression was upregulated in AML cells. CCK-8 assay revealed that SBF2-AS1 inhibition decreased AML cells proliferation ability in vitro. Flow cytometry assays showed that SBF2-AS1 inhibition induced AML cells apoptosis and arrested AML cells in G0/G1 phase. Mechanistically, miR-188-5p was identified as a direct target of SBF2-AS1. SBF2-AS1 upregulated the expression level of ZFP91 by sponging miR-188-5p. And the effects of SBF2-AS1 suppression on AML cells progression could be abolished by miR-188-5p inhibitors. Moreover, we found that SBF2-AS1 inhibition reduced tumor growth in vivo. Taken together, our findings elucidated that SBF2-AS1 could act as a miRNA sponge in AML progression, and provided a potential therapeutic strategy for AML treatment.

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“…For example, the lncRNA LOC105374902 promotes the malignancy of CC cells by acting as a sponge of miR-1285-3p, a process enhanced by TNF-α (25). Furthermore, the lncRNA SBF2-AS1 promotes the progression of CC by regulating the miR-361-5p/FOXM1 axis (26), while the lncRNA BDNF-Anti-Sense is downregulated in CC and possesses anti-tumor functions by negatively associating with brain-derived neurotrophic factor (27). RP11-480I12.5 is a newly identified lncRNA and, to the best of our knowledge, has not yet been extensively studied.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway

Zhang¹,

Sona³

2019

Oncol Lett

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T he long non-coding R NA (lncR NA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular mechanism of RP11-480I12.5 in CC. First, reverse transcription-quantitative PCR was implemented in order to detect differences in the expression of RP11-480I12.5 between normal and CC tissues. The present study used in vitro analysis to establish RP11-480I12.5 stable knockdown and overexpressing cell lines, in order to investigate the function and potential molecular mechanism of RP11-480I12.5 in the progression of CC. RP11-480I12.5 was upregulated in CC tissue compared with normal tissue. Furthermore, RP11-480I12.5 was associated with clinical stage, tumor size and lymph node metastasis. RP11-480I12.5 promoted the proliferation, migration and invasion of CC cell lines. Subsequently, the present study investigated the association between RP11-480I12.5 and the epithelial-to-mesenchymal transition (EMT) and Wnt/β-catenin pathways. RP11-480I12.5 promoted EMT through the Wnt/β-catenin pathway. Overall, the results of the present study demonstrate that RP11-480I12.5 promotes cercical cancer cell migration, invasion and EMT through the Wnt/β-catenin pathway.

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LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis

Cited by 66 publications

References 22 publications

Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis

Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis

Long noncoding RNA SBF2-AS1 act as a ceRNA to modulate cell proliferation via binding with miR-188-5p in acute myeloid leukemia

Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway

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