lncRNA SERPINB9P1 Regulates SIRT6 Mediated Osteogenic Differentiation of BMSCs via miR-545-3p

Wu, Min; Dai, Min; Liu, Xuqiang; Zeng, Qunqun; Lu, Yunhu

doi:10.1007/s00223-022-01034-3

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…LncRNAs are commonly found as competitive endogenous RNAs to sponge miRNAs and modulates downstream mRNAs function. For example, Wu found lncRNA SERPINB9P1 regulated BMSCs osteogenic differentiation via altering SIRT6 mRNA levels through its suppression on miR-545-3p 67 . However, most of the lncRNAs are found by RNA-seq for the first time and their functions are not annotated.…”

Section: Discussionmentioning

confidence: 99%

What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing

Li,

Cong,

Wang

et al. 2024

Int. J. Med. Sci.

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Evidence presented that osteoporosis is closely related to the dysfunction of bone mesenchymal stem cells (BMSCs). But most studies are insufficient to reveal what actually happens to the osteoporotic BMSCs. In this study, BMSCs were harvested from ovariectomized and sham-operated rats. After checking the characteristics of rat models and stem cells, the BMSCs were carried out for RNA sequencing. Part of the findings were verified that seven mRNAs (Abi3bp, Aifm3, Ccl11, Cdkn1c, Chst10, Id2, Vcam1) were significantly up-regulated in osteoporotic BMSCs while seven mRNAs (Cep63, Fgfr3, Myc, Omd, Pou2f1, Smarcal1, Timm10b) were down-regulated. In addition, potential miRNA-mRNA and lncRNA-mRNA regulatory networks were illustrated. The changes in osteoporotic BMSCs covered a large set of biological processes, including cell viability, differentiation, immunoreaction, bone repairment and estrogen defect. This study enriched the pathophysiological mechanisms of BMSCs and osteporosis, as well as provided dozens of attractive RNA targets for further treatment.

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Section: Discussionmentioning

confidence: 99%

What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing

Li,

Cong,

Wang

et al. 2024

Int. J. Med. Sci.

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“…LncRNA, functioning as a ceRNA, exerts a substantial influence on disease prevention and treatment by inhibiting miRNA expression through sponge adsorption and subsequently regulating downstream target genes. Furthermore, the comprehensive demonstration of the involvement of the "LncRNA miRNA" network loop in the treatment of OP has been established through its regulation of bone marrow mesenchymal stem cell (BMSC) differentiation into adipocytes and the maintenance of bone homeostasis (168)(169)(170). Moreover, it has been observed that certain traditional Chinese medicines, known for their therapeutic effects on OP, can also modulate the "LncRNA miRNA" network loop and influence BMSC's differentiation into adipocytes, suggesting that the therapeutic efficacy of traditional Chinese medicine in OP may be attributed to its impact on the "LncRNA miRNA" network loop.…”

Section: Discussionmentioning

confidence: 99%

Research progress on the role of lncRNA–miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis

Wang

et al. 2023

Front. Endocrinol.

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Osteoporosis (OP) is characterized by a decrease in osteoblasts and an increase in adipocytes in the bone marrow compartment, alongside abnormal bone/fat differentiation, which ultimately results in imbalanced bone homeostasis. Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts and adipocytes to maintain bone homeostasis. Several studies have shown that lncRNAs are competitive endogenous RNAs that form a lncRNA–miRNA network by targeting miRNA for the regulation of bone/fat differentiation in BMSCs; this mechanism is closely related to the corresponding treatment of OP and is important in the development of novel OP-targeted therapies. However, by reviewing the current literature, it became clear that there are limited summaries discussing the effects of the lncRNA–miRNA network on osteogenic/adipogenic differentiation in BMSCs. Therefore, this article provides a review of the current literature to explore the impact of the lncRNA–miRNA network on the osteogenic/adipogenic differentiation of BMSCs, with the aim of providing a new theoretical basis for the treatment of OP.

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“…The SERPINB9P1 gene has been reported to regulate osteogenic differentiation of bone marrow stromal cells. 40 Considering these features, methylation of this CpG site may have resulted in a decreased immune system and growth rate in maltreated children. It may be important to this methylation that the sensitivity period was at three years of age and that the CM occurred during a period of rapid growth.…”

Section: Discussionmentioning

confidence: 99%

Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents

Tomoda,

Nishitani,

Fujisawa

et al. 2023

Preprint

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Child maltreatment (CM) leads to adverse outcomes in later life. We describe the epigenome-wide analyses and meta-analysis results of three original cohorts consisting of judicially or socially certified CM cases and controls to gain further insight into the epigenetic signatures engraved in maltreated children. We also show associations with biological indicators (endophenotypes) in each cohort that represent CM features with maltreatment history, thus providing further confidence in the identified methylations. Four methylations in ATE1, CHST11, SERPINB9P1, and FOXP1 associate with CM in the meta-analysis, in addition to several genome-wide level significant methylations in each cohort. FOXP1, a gene related to neurodevelopmental disorders, is of particular interest, as its methylation level correlates with atypical brain structures representing in maltreated children and contributes to the accuracy of a methylation risk score to predict CM. These results suggest that severe CM experiences may contribute to neurodevelopmental-like and traumatic symptoms via epigenetic alterations.

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lncRNA SERPINB9P1 Regulates SIRT6 Mediated Osteogenic Differentiation of BMSCs via miR-545-3p

Cited by 7 publications

References 42 publications

What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing

What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing

Research progress on the role of lncRNA–miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis

Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents

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