LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis

Huang, Weizhen; Zhang, Hang; Tian, Yufang; Li, Yang; Li, Jun; Zhong, Xinghua; Yuan, Xiaocong

doi:10.1097/cad.0000000000001289

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…By contrast, the exosome-mediated delivery of miR-374a-5p inhibitor suppresses chemoresistance by increasing neuro D1 expression in gastric cancer cells [ 81 ]. The downregulation of SNHG11 induces apoptosis in bevacizumab-resistant CRC cells by targeting miR-1207-5p and decreasing the expression of ABCC1 [ 82 ]. Exosomal circSFMBT2 is highly expressed in the serum of docetaxel-resistant prostate cancer patients [ 83 ].…”

Section: Exosomal Non-coding Rnas As Regulators Of Cancer Progression...mentioning

confidence: 99%

“…In particular, mimics or inhibitors could be used in combination with chemotherapeutic drugs to overcome anticancer drug resistance. Table 2 [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ] and Figure 3 show the roles played by exosomal non-coding RNAs in cancer progression and anticancer drug resistance.…”

Section: Exosomal Non-coding Rnas As Regulators Of Cancer Progression...mentioning

confidence: 99%

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Exosomes: Diagnostic and Therapeutic Implications in Cancer

Shim

Jeoung

2023

Pharmaceutics

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Exosomes are a subset of extracellular vesicles produced by all cells, and they are present in various body fluids. Exosomes play crucial roles in tumor initiation/progression, immune suppression, immune surveillance, metabolic reprogramming, angiogenesis, and the polarization of macrophages. In this work, we summarize the mechanisms of exosome biogenesis and secretion. Since exosomes may be increased in the cancer cells and body fluids of cancer patients, exosomes and exosomal contents can be used as cancer diagnostic and prognostic markers. Exosomes contain proteins, lipids, and nucleic acids. These exosomal contents can be transferred into recipient cells. Therefore, this work details the roles of exosomes and exosomal contents in intercellular communications. Since exosomes mediate cellular interactions, exosomes can be targeted for developing anticancer therapy. This review summarizes current studies on the effects of exosomal inhibitors on cancer initiation and progression. Since exosomal contents can be transferred, exosomes can be modified to deliver molecular cargo such as anticancer drugs, small interfering RNAs (siRNAs), and micro RNAs (miRNAs). Thus, we also summarize recent advances in developing exosomes as drug delivery platforms. Exosomes display low toxicity, biodegradability, and efficient tissue targeting, which make them reliable delivery vehicles. We discuss the applications and challenges of exosomes as delivery vehicles in tumors, along with the clinical values of exosomes. In this review, we aim to highlight the biogenesis, functions, and diagnostic and therapeutic implications of exosomes in cancer.

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Section: Exosomal Non-coding Rnas As Regulators Of Cancer Progression...mentioning

confidence: 99%

Section: Exosomal Non-coding Rnas As Regulators Of Cancer Progression...mentioning

confidence: 99%

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Shim

Jeoung

2023

Pharmaceutics

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“…Several studies have reported the lack of association [ 190 , 192 ], whereas others have observed a link between TNM staging and differentiation grade and enhanced MRP1 expression in CRC biopsies, revealed by positive immunohistochemical staining [ 193 ]. Moreover, in vitro testing has demonstrated that MRP1 is associated with resistance to oxaliplatin, 5-FU, and bevacizumab [ 177 , 178 , 194 ]. Besides, the detection of MRP1 in circulating tumor cells in patients with CRC has recently been suggested as a biomarker of irinotecan resistance [ 179 , 195 ].…”

Section: Colorectal Carcinomamentioning

confidence: 99%

Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers

Marin

Monte

Macı́as

et al. 2022

Cancers

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Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the ten million deaths caused by cancer worldwide every year. The two main reasons for this high mortality are their late diagnosis and their high refractoriness to pharmacological treatments, regardless of whether these are based on classical chemotherapeutic agents, targeted drugs, or newer immunomodulators. Mechanisms of chemoresistance (MOC) defining the multidrug resistance (MDR) phenotype of each tumor depend on the synergic function of proteins encoded by more than one hundred genes classified into seven groups (MOC1-7). Among them, the efflux of active agents from cancer cells across the plasma membrane caused by members of the superfamily of ATP-binding cassette (ABC) proteins (MOC-1b) plays a crucial role in determining tumor MDR. Although seven families of human ABC proteins are known, only a few pumps (mainly MDR1, MRP1-6, and BCRP) have been associated with reducing drug content and hence inducing chemoresistance in hepatobiliary, pancreatic, and gastrointestinal cancer cells. The present descriptive review, which compiles the updated information on the expression of these ABC proteins, will be helpful because there is still some confusion on the actual relevance of these pumps in response to pharmacological regimens currently used in treating these cancers. Moreover, we aim to define the MOC pattern on a tumor-by-tumor basis, even in a dynamic way, because it can vary during tumor progression and in response to chemotherapy. This information is indispensable for developing novel strategies for sensitization.

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“…The lncRNAs affect cell growth, proliferation, apoptosis, and differentiation 26,27 via epigenetic mechanisms 28,29 . SNHG11, a potential prognostic marker in gastric cancer, 27 colorectal cancer, 30 hepatocellular carcinoma, 31 and prostate cancer, 32 promotes proliferation 33 and migration, 34 thereby suppressing apoptosis, 35 while impacting other cellular functions 36 …”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25] The lncRNAs affect cell growth, proliferation, apoptosis, and differentiation 26,27 via epigenetic mechanisms. 28,29 SNHG11, a potential prognostic marker in gastric cancer, 27 colorectal cancer, 30 hepatocellular carcinoma, 31 and prostate cancer, 32 promotes proliferation 33 and migration, 34 thereby suppressing apoptosis, 35 while impacting other cellular functions. 36 In this study, we found a decrease in the expression of SNHG11 in glaucomatous human TM (GTM 3 ) cells compared with immortalized human TM (iHTM) cells, while its role in TM cells remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA SNHG11 regulates the Wnt/β‐catenin signaling pathway through rho/ROCK in trabecular meshwork cells

et al. 2023

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Trabecular meshwork (TM) cell dysfunction is the leading cause of elevated intraocular pressure (IOP) and glaucoma. The long non-coding RNA (lncRNA) small nucleolar RNA host gene 11 (SNHG11) is associated with cell proliferation and apoptosis, but its biological functions and role in glaucoma pathogenesis remain unclear. In the present study, we investigated the role of SNHG11 in TM cells using immortalized human TM and glaucomatous human TM (GTM 3 ) cells and an acute ocular hypertension mouse model. SNHG11 expression was depleted using siRNA targeting SNHG11. Transwell assays, quantitative real-time PCR analysis (qRT-PCR), western blotting, and CCK-8 assay were used to evaluate cell migration, apoptosis, autophagy, and proliferation. Wnt/β-catenin pathway activity was inferred from qRT-PCR, western blotting, immunofluorescence, and luciferase reporter and TOPFlash reporter assays. The expression of Rho kinases (ROCKs) was detected using qRT-PCR and western blotting. SNHG11 was downregulated in GTM 3 cells and mice with acute ocular hypertension. In TM cells, SNHG11 knockdown inhibited cell proliferation and migration, activated autophagy, and apoptosis, repressing the Wnt/β-catenin signaling pathway, and activated Rho/ROCK. Wnt/β-catenin signaling pathway activity increased in TM cells treated with ROCK inhibitor. SNHG11 regulated Wnt/β-catenin signaling through Rho/ROCK by increasing GSK-3β expression and βcatenin phosphorylation at Ser33/37/Thr41 while decreasing βcatenin phosphorylation at Ser675. We demonstrate that the lncRNA SNHG11 regulates Wnt/β-catenin signaling through Rho/ROCK via βcatenin phosphorylation at Ser675 or GSK-3β-mediated

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LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis

Cited by 17 publications

References 35 publications

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Exosomes: Diagnostic and Therapeutic Implications in Cancer

Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers

Long non‐coding RNA SNHG11 regulates the Wnt/β‐catenin signaling pathway through rho/ROCK in trabecular meshwork cells

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