LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells

Wang, J.Z.; Xu, Cunlai; H, Wu; Shen, Shiwei

doi:10.1590/1414-431x20176079

Cited by 88 publications

(86 citation statements)

References 24 publications

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“…32 Wang et al put forward that SNHG12 augmented colon cancer proliferation, cell cycle progression and inhibited apoptosis by inhibiting the related proteins CDK4, CDK6 and CCND1, and suppressing CASP3. 54 Shorter overall survival rate and disease-free survival rate were correlated with higher DANCR expression. It was determined as an individual poor prognosis factor in colon cancer.…”

Section: Snhgs In Colorectal Cancermentioning

confidence: 93%

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.

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Section: Snhgs In Colorectal Cancermentioning

confidence: 93%

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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“…discovered that SNHG12 was up‐regulated in colorectal cancer tissues and cells. They also detected the effect of SNHG12 on cell proliferation, cell cycle, apoptosis and the related proteins expression in CRC cells . Subsequently, Wang et al .…”

Section: Small Nucleolar Rna Host Gene 12 (Snhg12)mentioning

confidence: 99%

Roles and expression profiles of long non‐coding RNAs in triple‐negative breast cancers

Kong

Liu

Kong

2017

J Cellular Molecular Medi

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Triple‐negative breast cancer (TNBC) refers to the breast cancers that express little human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR) and oestrogen receptor (ER). When compared to other types of breast cancers, TNBC behaves more aggressively with relatively poorer prognosis. Moreover, except chemotherapy, no targeted treatments have been approved yet until now. Although the molecular‐biological mechanisms of the initiation and development of TNBC have been explored a lot, the exact details underlying its progressions are still not clear. Long non‐coding RNAs (lncRNAs), with the length greater than 200 nucleotides, are non‐protein coding transcripts. Previous researches have shown that lncRNAs are significantly involved in a variety of pathophysiological processes such as cell migration, invasion, proliferation, differentiation and development. lncRNAs’ dysregulated expressions have been observed in many types of tumours including TNBCs. This article will review the functional roles and dysregulations of lncRNAs in TNBCs. These lncRNAs are worthy of exploitation regarding their potential application values of TNBC's diagnosis and treatment.

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“…Intriguingly, lncRNA small nucleolar RNA host genes (SNHGs) have been reported to have close associations with tumor growth and metastasis, and SNHG1/5/12 specifically enhances tumorigenesis and metastasis in non-small cell lung cancer [14], gastric cancer (GC) [15], colorectal cancer (CRC) [16], and HCC [17] by targeting miR-101-3p [14], miR-32 [15], and miR-199a/b [17]. However, SNHG5 suppresses GC progression by trapping MTA2 in the cytosol [18], suggesting that SNHGs may also represent novel therapeutic targets for cancer.…”

Section: Introductionmentioning

confidence: 99%

lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma

Dong

Teng

Guo

et al. 2018

Cell Physiol Biochem

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Background/Aims: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays a key role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which SNHG8 contributes to HCC remain elusive and merit exploration. Methods: The association between SNHG8 expression and the clinicopathological characteristics and prognoses in HCC patients was analysed by using qRT-PCR analysis and the data from The Cancer Genome Atlas. Cell growth and metastatic potential were determined by MTT, colony formation, Transwell assays, and the mouse xenograft tumor model and lung metastasis model. Epithelial–mesenchymal transition markers were detected by western blot analysis. The binding capacity of SNHG8 with miRNAs was evidenced by bioinformatic analysis and a luciferase reporter assay. In addition, the rescue experiments were performed based on co-transfection with sh-SNHG8 and a miR-149 inhibitor in HCC cells. Results: The expression levels of lncRNA SNHG8 were dramatically increased in HCC tissues and cell lines as compared with the adjacent normal tissues, and SNHG8 expression was an independent prognostic factor of tumor recurrence in HCC patients. Furthermore, knockdown of SNHG8 inhibited cell proliferation, invasion, and lung metastasis in vitro and in vivo, whereas overexpression of SNHG8 reversed these effects. SNHG8 acted as a sponge of miR-149 and counteracted the tumor suppressive effects of mi R-149 in HCC cells. Expression of phosphatase, Mg2+/Mn2+ dependent 1F, a target of R-149, displayed a negative correlation with miR-149 expression but a positive correlation with SNHG8 expression in HCC specimens. Conclusion: As lncRNA SNHG8 may promote HCC tumorigenesis and metastasis by sponging miR-149, it is a potential candidate marker and therapeutic target for HCC.

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LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells

Cited by 88 publications

References 24 publications

Long non‐coding small nucleolar RNA host genes in digestive cancers

Long non‐coding small nucleolar RNA host genes in digestive cancers

Roles and expression profiles of long non‐coding RNAs in triple‐negative breast cancers

lncRNA SNHG8 Promotes the Tumorigenesis and Metastasis by Sponging miR-149-5p and Predicts Tumor Recurrence in Hepatocellular Carcinoma

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