LncRNA SNHG15: A new budding star in human cancers

Shuai, You; Ma, Zhonghua; Lu, Jianwei; Feng, Jifeng

doi:10.1111/cpr.12716

Cited by 41 publications

(26 citation statements)

References 149 publications

(615 reference statements)

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“…To further clarify the relationship between linc01503 level and survival outcome of patients with GC, the Kaplan‐Meier plotter (KmPlot), which has been used in various cancers, was implicated in this research (http://kmplot.com/analysis) 18‐22 …”

Section: Resultsmentioning

confidence: 99%

EGR1‐mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer

Gao

Shuai

et al. 2020

Cell Proliferation

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Objectives Long non‐coding RNAs (lncRNAs) are key mediators in various malignancies. Linc01503 was previously elucidated to promote gastric cancer (GC) cell invasion. However, the upstream mechanism of linc01503 and its involvement in GC cell cycle, apoptosis and tumorigenesis still remain unclear. Materials and Methods Bioinformatics analysis and quantitative reverse transcription polymerase chain reaction (qRT‐PCR) assays were implicated to detect linc01503 level in GC. The role of linc01503 was detected by in vitro functional assays and in vivo xenograft tumour models. The association between linc01503 and its upstream effector was identified by chromatin immunoprecipitation (ChIP) assays. The mechanistic model of linc01503 was clarified using subcellular separation, fluorescence in situ hybridization, RNA‐sequencing, RNA immunoprecipitation (RIP) and ChIP assays. Results Linc01503 was remarkably elevated in GC and tightly linked with the overall survival of patients with GC. The key transcription factor early growth response protein 1 (EGR1) critically activated the transcription of linc01503. Functionally, linc01503 knockdown resulted in the activation of apoptosis and G1/G0 phase arrest in GC. Mechanistically, linc01503 interacted with histone modification enzyme enhancer of zeste 2 (EZH2) and lysine (K)‐specific demethylase 1A (LSD1), thereby mediating the transcriptional silencing of dual‐specificity phosphatase 5 (DUSP5) and cyclin‐dependent kinase inhibitor 1A (CDKN1A) in GC. Conclusions EGR1‐activated linc01503 could epigenetically silence DUSP5/CDKN1A expression to mediate cell cycle progression and tumorigenesis, implicating it as a prospective target for GC therapeutics.

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Section: Resultsmentioning

confidence: 99%

EGR1‐mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer

Gao

Shuai

et al. 2020

Cell Proliferation

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“…Aberrant lncRNA expression has been validated to be closely linked with cell death in ischemic stroke progression [ 5 ]. SNHG15 has been widely identified as an onco-lncRNA in multiple cancer types [ 12 ], but its role in other diseases is less studied. The present study validated that SNHG15 is highly expressed in MCAO-treated mice and OGD-treated N2a cells, which aggravates neuronal injury after ischemic stroke with the involvement of the miR-18a/CXCL13/ERK/MEK axis.…”

Section: Discussionmentioning

confidence: 99%

“…Several such networks have been validated to fulfill key functions in neuron apoptosis and nerve injury after ischemic stroke [ 10 , 11 ]. Small nucleolar RNA host gene 15 (SNHG15) is a strongly conserved lncRNA located at 7p13 with 860 bp in length, and its functions in tumor progression in several human cancers have been well documented [ 12 ]. SNHG15 has been noted to promote glioma progression [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis

et al. 2020

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“…In HCC, moreover, snoRNA SNORD113-1 was also found to be significantly downregulated and functions as a tumor suppressor role [ 23 ]. SNHG16, SNORD76, and SnoU2_19 can regulate the development of HCC through Wnt/ β -catenin signaling pathway [ 29 ]. Therefore, these indicated that some specific snoRNAs had underlying abilities to serve as biomarker for clinical evaluation of HCC patients.…”

Section: Discussionmentioning

confidence: 99%

Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma

et al. 2020

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Background. Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process. Recently, dysregulation of snoRNA SNORA71A has been found involved in tumorigenesis of various malignant cancers. However, the emerging effects of SNORA71A in hepatocellular carcinoma (HCC) remain largely unclear. In this study, we aimed to explore the SNORA71A expression and its underlying significance in HCC. Methods. Expression of SNORA71A in cell lines and clinical specimens was measured by quantitative real-time PCR. Then, all enrolled HCC patients were divided into low and high SNORA71A expression subgroups and then they were compared in the aspects of clinical features as well as survival outcome by respective statistical analysis methods. Results. SNORA71A was significantly downexpressed in SK-HEP-1 (P=0.001), Huh-7 (P<0.001), Hep3B (P<0.001), and clinical HCC specimens (P=0.006). Comparing the clinical features between SNORA71A expression subgroups, it showed that low SNORA71A expression was significantly associated with large tumor diameter, multiple lesions, capsular invasion, bad tumor differentiation, and TNM stage (P<0.05). Furthermore, it was found that HCC patients with lower SNORA71A expression had higher risk in postoperative tumor relapse (median time: 9.5 vs. 35.2 months; low vs. high; P<0.001) and poor overall survival (median time: 36.8 vs. 52.9 months; low vs. high; P<0.001). Besides, SNORA71A expression served as independent risk factors for tumor-free (HR=0.450; 95% CI [0.263-0.770]; P=0.004) and long-term survival (HR=0.289; 95% CI [0.127-0.657]; P=0.003). Conclusions. Our study for the first time demonstrated that downregulation of SNORA71A could serve as a novel biomarker for clinical assessment and prognostic prediction of HCC patients.

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LncRNA SNHG15: A new budding star in human cancers

Cited by 41 publications

References 149 publications

EGR1‐mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer

EGR1‐mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer

Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis

Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma

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