LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression

Chen, Zhiping; Zhong, Tianyu; Li, Tao; Zhong, Jinghua; Tang, Yang; Liu, Zhanyu; Ling, Baodian; Wang, Lanfeng

doi:10.1042/bsr20204177

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…LncRNA LINC01018 inhibits the progression of AML by targeting miR-499-5p to regulate PDCD4 (71). Moreover, lncRNA SNHG15 was reported to executed oncogenic proprieties in GC by impairing miR-506-5p expression (72). A very recent study has shown that LncRNA LINC01410 induced by Myc accelerates Glioma progression via decreasing the expression of miR-506-3p and Modulating Notch2 Expression to motivate Notch signaling pathway.…”

Section: Inhibition Of Ts Mirna By Long Non Coding Rnasmentioning

confidence: 99%

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

2021

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MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important posttranscriptional regulators of gene expression. miRNAs production is controlled at multiple levels, including transcriptional and posttranscriptional regulation. Extensive profiling studies have shown that the regulation of mature miRNAs expression plays a causal role in cancer development and progression. miRNAs have been identified to act as tumor suppressors (TS) or as oncogenes based on their modulating effect on the expression of their target genes. Upregulation of oncogenic miRNAs blocks TS genes and leads to tumor formation. In contrast, downregulation of miRNAs with TS function increases the translation of oncogenes. Several miRNAs exhibiting TS properties have been studied. In this review we focus on recent studies on the role of TS miRNAs in cancer cells and the tumor microenvironment (TME). Furthermore, we discuss how TS miRNA impacts the aggressiveness of cancer cells, with focus of the mechanism that regulate its expression. The study of the mechanisms of miRNA regulation in cancer cells and the TME may paved the way to understand its critical role in the development and progression of cancer and is likely to have important clinical implications in a near future. Finally, the potential roles of miRNAs as specific biomarkers for the diagnosis and the prognosis of cancer and the replacement of tumor suppressive miRNAs using miRNA mimics could be promising approaches for cancer therapy.

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Section: Inhibition Of Ts Mirna By Long Non Coding Rnasmentioning

confidence: 99%

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

2021

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“… 32 For instance, lncRNA SNHG15 promotes gastric cancer tumorigenesis by impairing miR-506-5p expression. 31 FOXD2-AS1 facilitates cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p. 32 In this study, we demonstrated that overexpression of miR-506-5p could inhibit the proliferation, migration and EMT of gastric cancer cells, while enhanced LINC01232 abundance could interrupt the tumor suppressor effect of miR-506-5p.…”

Section: Discussionmentioning

confidence: 99%

“…Limited evidence showed that miR-506-5p act as a tumor suppressor and interact with lncRNAs in gastric cancer 31 and glioma. 32 For instance, lncRNA SNHG15 promotes gastric cancer tumorigenesis by impairing miR-506-5p expression.…”

Section: Discussionmentioning

confidence: 99%

LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer

Chen¹,

Liao²,

Xu³

et al. 2022

CMAR

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Background Long non-coding RNA LINC01232 plays an important role in the progression of metastasis in several cancers. However, the function of LINC01232 in gastric cancer is limited. Authors aimed to investigate the role and mechanism of LINC01232 in the metastasis of gastric cancer. Methods The expression levels and correlation of LINC01232, miR-506-5p, and PAK1 were analyzed by GEPIA or ENCORI, and the abundance of LINC01232 and miR-506-5p was measured in tissues and cells via qRT-PCR, the location of LINC01232 in gastric cells was analyzed by nuclear and cytoplasmic fractionation, while the protein levels of PAK1, E-cadherin and vimentin were additionally quantified by Western blotting. Interactions between LINC01232, miR-506-5p, and PAK1 were detected through luciferase reporter assays, qRT-PCR and Western blotting. Cellular viability was evaluated through CCK8 assays, migration ability was measured by transwell assays, invasion ability was tested by wound healing experiment. Results LINC01232 was overexpressed in gastric cancer tissues and cells, and mainly located in nucleus. The inhibition of LINC01232 could suppress migration, invasion and EMT of gastric cancer cells. MiR-506-5p was downregulated in gastric cancer tissues and cells. LINC01232 sponged miR-506-5p to accelerate migration and EMT. PAK1 was certified to be a target of miR-506-5p, inhibition of PAK1 could interrupt LINC01232 overexpression-induced migration of gastric cancer cells. Conclusion The LINC01232/miR-506-5p/PAK1 axis promotes metastasis of gastric cancer cells.

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“…SNHG15 was firstly reported in 2012 [ 28 ]. Subsequently, SNHG15 was investigated in tumor, and the SNHG15 expression was upregulated in cancers and high SNHG15 expression predicted poor prognosis, for instance, gastric cancer [ 17 ], lung cancer [ 18 ], colorectal cancer [ 29 ], and glioma [ 24 ]. Consistent with the recent evidence raised by Zhang et al [ 30 ], our results showed that SNHG15 was upregulated in ovarian cancer; it is noteworthy that our results were based on the GEO dataset and verified by the specimen of our own; this makes the results more reliable.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, SNHG15 was described as an oncogenic lncRNA in several cancers [ 17 – 19 ] but the role of SNGH15 in ovarian cancer remains unclear. Herein, SNHG15 was identified by using GEO datasets and validated by ovarian cancer tissues and we investigated the clinical value and mechanism of SNHG15 in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR‐370‐3p

Wang

Ding

Yuan

et al. 2021

BioMed Research International

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Ovarian cancer is a kind of cancer from the female genital tract; the molecular mechanism still needs to be explored. lncRNA plays a vital role in tumorigenesis and development. Our aim was to identify oncogenic lncRNAs in ovarian cancer and explore the potential molecular mechanism. SNHG15 was initially identified by using GEO datasets (GSE135886 and GSE119054) and validated by tumor tissues and the cell line, identifying that SNHG15 was upregulated in ovarian cancer. Besides, high SNHG15 indicated poor prognosis in ovarian cancer. Furthermore, knockdown SNHG15 suppresses ovarian cancer proliferation and promotes apoptosis. Mechanistically, SNHG15 promotes proliferation through upregulated CDK6 via sponging miR-370-3p. Taken together, our findings emphasize the important role of SNHG15 in ovarian cancer, suggesting that SNHG15 may be a promising target for ovarian cancer.

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LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression

Cited by 18 publications

References 31 publications

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer

lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR‐370‐3p

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