LncRNA SNHG16 Functions as an Oncogene by Sponging MiR-135a and Promotes JAK2/STAT3 Signal Pathway in Gastric Cancer

Wang, Xinguo; Kan, Jie; Han, Jikhyon; Zhang, Wenyan; Bai, Liyan; Wu, Hao

doi:10.7150/jca.29527

Cited by 73 publications

(66 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the abnormal regulations between long noncoding RNA (lncRNA) and messenger RNA (mRNA), some studies have shown that lncRNA can promote the proliferation and metastasis of gastric cancer cells by regulating the differentially expressed mRNA. [9][10][11] In recent years, the study have found a new regulatory mechanism called "competitive endogenous RNA (ceRNA)" between the coding RNA and noncoding RNA. 2,4,8 For the relationships of lncRNA-miRNA, although lncRNA and miRNA do not have the function of encoding proteins, the mutual regulations between lncRNA and miRNA can lead to abnormal expression of some signaling pathways and have an important influence on the growth, metastasis, metabolism, and apoptosis of gastric cancer cells.…”

mentioning

confidence: 99%

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Wang

Ding

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

The oncogenesis and progression of gastric cancer are closely correlated with the complex regulatory relationships among messenger RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA). After constructing the gastric cancer lncRNA‐miRNA‐mRNA regulatory network, we analyzed the network topology properties and found that lncRNA ADAMTS9‐AS2 and C20orf166‐AS1 and miRNA hsa‐mir‐204 are key nodes. Further functional enrichment analysis and survival analysis were performed on these key nodes and the RNAs interacting with them. We found that CHRM2, ANGPT2, and COL1A1 interacting with ADAMTS9‐AS2 are enriched in the PI3K‐Akt signaling pathway, and low expression of the ADAMTS9‐AS2 is closely related to the prognosis of patients. Abnormal expression of CACNA1H, FLNA, and FLNC interacting with lncRNA C20orf166‐AS1 is associated with MAPK signaling pathway in gastric cancer. In addition, the downregulated miRNA hsa‐mir‐204 promotes invasion and proliferation of gastric cancer cells by regulating the abnormal expression of mRNAs (CHRDL1 and NPTX1) and lncRNAs (ADAMTS9‐AS2, NKX2‐1‐AS1, TLR8‐AS1, and VCAN‐AS1). This study systematically analyzed the lncRNA‐miRNA‐mRNA regulatory network of gastric cancer, which not only has a new understanding of the pathogenesis of gastric cancer, but also provides new insights for the early diagnosis and treatment of gastric cancer.

show abstract

mentioning

confidence: 99%

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Wang

Ding

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…The experiment was applied to monitor the relative expression of RNA in samples from cells or tissues [22].…”

Section: Quantitative Real-time Pcr (Rt-qpcr)mentioning

confidence: 99%

CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis

Cong

Zhang

et al. 2020

Cancer Cell Int

View full text Add to dashboard Cite

Background: Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies, including gastric cancer (GC). Researches concerning cancers have revealed that aberrant expression of circRNAs play a big part in tumorigenesis and development of diverse malignant tumors. Although hsa_circ_0014130 (circPIP5K1A) has been confirmed to be closely related to non-small cell lung cancer (NSCLC) progression, the knowledge of its function on GC progression remains unclear. Therefore, it is of great interest to uncover the underlying role of circPIP5K1A in GC. Methods: The expression and characteristic of circPIP5K1A were separately analyzed by RT-qPCR, nucleic acid electrophoresis, RNase R and Actinomycin D treatment. CCK-8, colony formation, EdU, transwell, TUNEL, flow cytometry, luciferase reporter, RIP and RNA pull-down assays were employed to testify the regulatory role of circPIP5K1A in GC. Results: In current study, circPIP5K1A, featured with closed-loop structure, was proved to be highly expressed in tissues and cells of GC. Loss-of-function assays depicted that silencing circPIP5K1A suppressed GC development. Followup mechanism tests unveiled that circPIP5K1A bound with miR-376c-3p and inhibition of miR-376c-3p reversed circ-PIP5K1A downregulation-mediated effect on GC progression. Additionally, ZNF146 was verified to be the downstream molecule of circPIP5K1A/miR-376c-3p axis in modulating GC progression. Conclusions: circPIP5K1A stimulates GC progression by sponging miR-376c-3p to upregulate ZNF146 expression.

show abstract

“…shown that patients with elevated expression of SNHG16 had poor OS in comparison with those with low levels [10][11][12][13][14][15][16][18][19][20][21][22][23][24]. Not only in cancer, recent evidence suggests that SNHG16 also has a significant impact on regulating the inflammatory response.…”

Section: Publication Biasmentioning

confidence: 99%

Clinicopathological significance and prognosis of long noncoding RNA SNHG16 expression in human cancers: a meta-analysis

Jiao

Jiang

Wei

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Recent studies have highlighted the important role of long non-coding RNA SNHG16 in various human cancers. Here, we conducted a meta-analysis to investigate the effect of SNHG16 expression on clinicopathological features and prognosis in patients with different kinds of human cancers.Methods We performed a systematic search in electronic databases including PubMed, EMBASE, Cochrane Library and Web of Science, to investigate the potential association between SNHG16 expression and prognostic significance and clinical features in cancer patients. Odds ratios (ORs) or hazards ratios (HRs) with corresponding 95% confidence intervals (95% CIs) were pooled to estimate the prognosis value of SNHG16 by StataSE 15.0 software.Results A total of 16 eligible studies with 1299 patients were enrolled in our meta-analysis. The results revealed that increased expression level of SNHG16 was significantly associated with larger tumor size (OR: 3.357; 95% CI: 2.173-5.185; P < 0.001), advanced TNM stage (OR: 2.930; 95% CI: 1.522-5.640; P = 0.001) and poor histological grade (OR: 3.943; 95% CI: 1.955-7.952; P < 0.001), but not correlated with smoking status (P = 0.489), sex (P = 0.932), distant metastasis (P = 0.052), or lymph node metastasis (P = 0.155). Moreover, the pooled HR showed that elevated expression SNHG16 was associated with a significantly poorer overall survival (OS) (HR=1.866, 95% CI: 1.571-2.216, P <0.001).Conclusions LncRNA SNHG16 overexpression might serve as a convinced unfavorable prognostic factor, which provides a basis for medical workers to evaluate the prognosis of patients and to help the decision-making process.

show abstract

LncRNA SNHG16 Functions as an Oncogene by Sponging MiR-135a and Promotes JAK2/STAT3 Signal Pathway in Gastric Cancer

Cited by 73 publications

References 29 publications

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

Identification of the complex regulatory relationships related to gastric cancer from lncRNA‐miRNA‐mRNA network

CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis

Clinicopathological significance and prognosis of long noncoding RNA SNHG16 expression in human cancers: a meta-analysis

Contact Info

Product

Resources

About