LncRNA SNHG4 promotes the increased growth of endometrial tissue outside the uterine cavity via regulating c-Met mediated by miR-148a-3p

Liu, Yanjun; Huang, Xiaowu; Lü, Dan; Feng, Yue-Lan; Xu, Ruifang; Li, Xuan; Yin, Chenghong; Xue, Bing; Zhao, Huanying; Wang, Shuyu; Ma, Yanmin; Chen, Jia

doi:10.1016/j.mce.2020.110887

Cited by 17 publications

(19 citation statements)

References 21 publications

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“…Besides, Liu et al . found that the reduced abundance level of miR-148a-3p leads to the higher abundance level of its target gene, the small nucleolar RNA host gene 4 ( SNHG4 ), and thus has a direct influence on the ectopic growth of the endometrium outside the uterus 32 . As for miR-28-5p, Vanhie et al .…”

Section: Discussionmentioning

confidence: 99%

Characterization of micro-RNA in women with different ovarian reserve

Abu‐Halima

Becker

Ayesh

et al. 2021

Sci Rep

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Women undergoing infertility treatment are routinely subjected to one or more tests of ovarian reserve. Therefore, an adequate assessment of the ovarian reserve is necessary for the treatment. In this study, we aimed to characterize the potential role of microRNAs (miRNAs) as biomarkers for women with different ovarian reserves. A total of 159 women were recruited in the study and classified according to their anti-Müllerian hormone (AMH) level into three groups: (1) low ovarian reserve (LAMH, n = 39), (2) normal ovarian reserve (NAMH, n = 80), and (3) high ovarian reserve (HAMH, n = 40). SurePrint Human miRNA array screening and reverse transcription-quantitative PCR (RT-qPCR) were respectively employed to screen and validate the miRNA abundance level in the three tested groups. Compared with NAMH, the abundance level of 34 and 98 miRNAs was found to be significantly altered in LAMH and HAMH, respectively. The abundance level of miRNAs was further validated by RT-qPCR in both, the screening samples as well as in an independent set of validation samples. The abundance levels of the validated miRNAs were significantly correlated with the AMH level. The best AUC value for the prediction of the increase and decrease in the AMH level was obtained for the miR-100-5p and miR-21-5p, respectively. The level of miRNAs abundance correlates with the level of AMH, which may serve as a tool for identifying women with a different ovarian reserve and may help to lay the ground for the development of novel diagnostic approaches.

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Section: Discussionmentioning

confidence: 99%

Characterization of micro-RNA in women with different ovarian reserve

Abu‐Halima

Becker

Ayesh

et al. 2021

Sci Rep

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“…In ACI [ 20 ], NP [ 30 ], DR [ 19 ], AML [ 21 ], neuroblastoma [ 33 ], CRC [ 35 ], cervical cancer (CC) [ 80 ], non-small-cell lung cancer (NSCLC) [ 28 ], and endometriosis [ 81 ], researchers explored the expression of SNHG4 in patients with these diseases. However, they did not seem to have studied the relationship between SNHG4 and the clinical features of these diseases, nor have they explored the relationship between SNHG4 and disease prognosis.…”

Section: Snhg4 In Human Studiesmentioning

confidence: 99%

“…Similarly, SNHG4 knockdown could inhibit RCC [ 32 ], CRC [ 35 ], osteosarcoma [ 71 ], CC [ 80 ], lung cancer [ 82 ], and NSCLC [ 28 ] tumour growth. In addition, Liu and colleagues [ 81 ] pointed out that silencing SNHG4 inhibited the growth of endometrial tissue outside the uterine cavity in vivo . In summary, the results of in vivo studies showed that SNHG4 not only plays a tumorigenic role in some cancers but also promotes the growth of intimal tissues in non-tumour diseases such as endometriosis.…”

Section: Snhg4 In In Vivo Studiesmentioning

confidence: 99%

“…Next, we will mainly introduce the in vitro cell function verification of SNHG4. A large number of studies have revealed that SNHG4 mainly promotes proliferation, invasion, migration, apoptosis inhibition and EMT [ 31 , 35 , 70 , 81 ]. In addition, Zhang and Pan et al [ 20 , 22 ] found that SNHG4 has dual pro-inflammatory and anti-inflammatory functions (Table 2 ).…”

Section: Snhg4 In Cell Lines Studiesmentioning

confidence: 99%

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Long noncoding RNA SNHG4: a novel target in human diseases

Chu

Zheng

et al. 2021

Cancer Cell Int

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Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member of the lncRNA SNHG family, is abnormally expressed in a variety of human diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate cancer, colorectal cancer, osteosarcoma, cervical cancer, liver cancer, lung cancer, non-small-cell lung cancer, neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, acute myeloid leukaemia, and endometriosis. In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SNHG4 in the above diseases. In addition, the specific mechanism of SNHG4 as a competing endogenous RNA (ceRNA) is discussed. The findings indicate that SNHG4 can be used as a biomarker for disease prognosis evaluation and as a potential target for disease diagnosis and treatment.

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“…The inhibitor of miR-148a-3p combined with SNHG4 knockdown rescued endometriotic lesions growth and upregulated the MET expression. The authors postulated that SNHG4 might upregulate proto-oncogene expression, in particular MET, via the suppression of miR-148a-3p, to promote the increased growth of endometrial tissue outside the uterine cavity and endometriosis lesions [ 110 ]. The impact of oncogenes and the manipulation of oncogenes in therapy for endometriosis deserves future study, particularly as non-hormonal therapies.…”

Section: Therapeutic Opportunities For Lncrnasmentioning

confidence: 99%

Translational Applications of Linear and Circular Long Noncoding RNAs in Endometriosis

Wang

Parodi

Hawkins

2021

IJMS

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Endometriosis is a chronic gynecologic disease that negatively affects the quality of life of many women. Unfortunately, endometriosis does not have a cure. The current medical treatments involve hormonal manipulation with unwanted side effects and high recurrence rates after stopping the medication. Sadly, a definitive diagnosis for endometriosis requires invasive surgical procedures, with the risk of complications, additional surgeries in the future, and a high rate of recurrence. Both improved therapies and noninvasive diagnostic tests are needed. The unique molecular features of endometriosis have been studied at the coding gene level. While the molecular components of endometriosis at the small RNA level have been studied extensively, other noncoding RNAs, such as long intergenic noncoding RNAs and the more recently discovered subset of long noncoding RNAs called circular RNAs, have been studied more limitedly. This review describes the molecular formation of long noncoding and the unique circumstances of the formation of circular long noncoding RNAs, their expression and function in endometriosis, and promising preclinical studies. Continued translational research on long noncoding RNAs, including the more stable circular long noncoding RNAs, may lead to improved therapeutic and diagnostic opportunities.

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LncRNA SNHG4 promotes the increased growth of endometrial tissue outside the uterine cavity via regulating c-Met mediated by miR-148a-3p

Cited by 17 publications

References 21 publications

Characterization of micro-RNA in women with different ovarian reserve

Characterization of micro-RNA in women with different ovarian reserve

Long noncoding RNA SNHG4: a novel target in human diseases

Translational Applications of Linear and Circular Long Noncoding RNAs in Endometriosis

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