LncRNA-SNPs in a Brazilian Breast Cancer Cohort: A Case-Control Study

Mathias, Carolina; Marin, Anelis Maria; Kohler, Ana Flávia; Sanchuki, Heloisa Bruna Soligo; Sukow, Natalie Mary; Beltrame, Márcia Holsbach; Baal, Suelen Cristina Soares; Sebastião, Ana Paula Martins; Ribeiro, Enilze Maria de Souza Fonseca; Gradia, Daniela Fiori; Aoki, Mateus Nóbrega; Oliveira, Jaqueline Carvalho de

doi:10.3390/genes14050971

Cited by 2 publications

References 35 publications

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CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Yin,

Tong,

Wan

et al. 2023

BMC Cancer

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Background Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This study aimed to explore the relationship between CYP4B1 single nucleotide polymorphisms (SNPs) and BC risk in Chinese women. Methods A case-control study of 1,143 women (571 patients and 572 healthy individuals) was conducted. Rs2297813 G/T, rs12142787 G/A, and rs3766197 C/T in CYP4B1 were selected and genotyped by MassARRAY system. The relationships between these SNPs and the risk of BC were assessed by logistic regression analysis. In addition, multi-factor dimensionality reduction (MDR) was used to analyze SNP-SNP interactions. Results CYP4B1 rs2297813 had a risk-increasing effect on BC in women with body mass index (BMI) ≤ 24 kg/m2 (OR = 1.72, p = 0.026). CYP4B1 rs12142787 was associated with an increased BC risk in smokers (AA: OR = 1.32, p = 0.045). Among non-drinkers, rs2297813 (OR = 1.69, p = 0.009) and rs12142787 (OR = 1.51, p = 0.020) were related to an increased incidence of BC. CYP4B1 rs3766197 (OR = 1.61p = 0.031) was associated with a higher risk of advanced stages (III/IV stage) of BC. Besides, the contributions of CYP4B1 rs2297813 (OR = 1.55, p = 0.021) and rs12142787 (OR = 1.53, p = 0.033) to BC risk might be associated with more than one birth in patients with BC. The three-locus model consisting of rs2297813, rs12142787, and rs3766197 was regarded as the best predictive model for BC risk. Conclusion CYP4B1 SNPs were associated with BC risk in Chinese women, especially in patients with BMI ≤ 24 kg/m2, smokers, non-drinkers, patients in advanced stages (III/IV stage), and patients who reproduced once. These findings shed light on the relationship between CYP4B1 SNPs and BC risk in Chinese women.

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CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Yin,

Tong,

Wan

et al. 2023

BMC Cancer

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Comprehensive analysis to investigate the association between IL-8 gene polymorphisms and the risk of cancer from 135 case-control studies

Xu,

Yan

2023

Preprint

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Background The association between polymorphisms in the interleukin-8 (IL-8) gene and the development of cancer risk have been investigated in many studies. Nonetheless, the past findings have needed to be more consistent and conclusive. Thus, the current study aims to comprehensively evaluate the association between IL-8 gene polymorphisms and cancer risk. Methods The literature survey was conducted across multiple databases. The search comprised all relevant publications conducted on June 23, 2023. Results In accordance with the predefined search criteria for assessing cancer susceptibility, an inclusive meta-analysis was conducted, containing 135 case-control studies. This investigation yielded a collection of six distinct polymorphisms (-251, -353, + 678, +1633, + 2767, +781), which were identified and documented. The association strength was evaluated via odds ratios with 95% confidence intervals. This research has made a significant discovery regarding the − 251 polymorphism and its potential association with increased cancer risk. The resulting analyses encompassed various populations, including Asians and individuals of mixed ancestry, as well as different sources of control, precisely hospital-based sources. Furthermore, the study examined multiple types of cancer, such as gastric, glioma, bladder, and colorectal. These examinations suggest that the − 251 polymorphism may have been implicated in elevating the susceptibility to these malignancies. The − 353 polymorphism was identified as a potential risk factor that indicated its involvement in cancer development, while the + 781 polymorphism was also linked with elevated cancer risk. Conclusions Overall, the investigation has revealed that IL-8 gene polymorphisms significantly influence vulnerability to cancer development.

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LncRNA-SNPs in a Brazilian Breast Cancer Cohort: A Case-Control Study

Cited by 2 publications

References 35 publications

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study

Comprehensive analysis to investigate the association between IL-8 gene polymorphisms and the risk of cancer from 135 case-control studies

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