LncRNA-SNX17 Promotes HTR-8/SVneo Proliferation and Invasion Through miR-517a/IGF-1 in the Placenta of Diabetic Macrosomia

Song, Guanhua; Na, Quan; Wang, Ruo‐Chen; Wang, Dan; Chen, Bingnan; Yuan-yua, LI; Bian, Yue; Jin, Feng; Qiao, Chong; Wang, Leilei

doi:10.1007/s43032-021-00687-z

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…Hsa-miR-517a-3p|hsa-miR-517b-3p was found downregulated in women with GDM, suggesting that its expression is insufficient to exert its potential effects on insulin sensitivity and counterbalance the insulin resistance state in pregnancy. Hsa-miR-517a-3p|hsa-miR-517b-3p has been found to be downregulated in the placentas of diabetic women with fetal macrosomia (39), which is consistent with our results. Our results are in line with Santovito et al (40) who found downregulation of let-7a in plasma of non-treated T2D patients and that its levels were increased 12 months after treatment initiation.…”

Section: Discussionsupporting

confidence: 92%

First Trimester Plasma MicroRNA Levels Predict Risk of Developing Gestational Diabetes Mellitus

Légaré

Desgagné²,

Thibeault³

et al. 2022

Front. Endocrinol.

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AimsOur objective is to identify first-trimester plasmatic miRNAs associated with and predictive of GDM.MethodsWe quantified miRNA using next-generation sequencing in discovery (Gen3G: n = 443/GDM = 56) and replication (3D: n = 139/GDM = 76) cohorts. We have diagnosed GDM using a 75-g oral glucose tolerance test and the IADPSG criteria. We applied stepwise logistic regression analysis among replicated miRNAs to build prediction models.ResultsWe identified 17 miRNAs associated with GDM development in both cohorts. The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR-218-5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs. 0.75). MiRNAs and GDM classic risk factors together further improved the prediction values [AUC 0.84 (95% CI 0.73–0.94)]. These results were replicated in 3D, although weaker predictive values were obtained. We suggest very low and higher risk GDM thresholds, which could be used to identify women who could do without a diagnostic test for GDM and women most likely to benefit from an early GDM prevention program.ConclusionsIn summary, three miRNAs combined with classic GDM risk factors provide excellent prediction values, potentially strong enough to improve early detection and prevention of GDM.

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Section: Discussionsupporting

confidence: 92%

First Trimester Plasma MicroRNA Levels Predict Risk of Developing Gestational Diabetes Mellitus

Légaré

Desgagné²,

Thibeault³

et al. 2022

Front. Endocrinol.

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“…Inhibition of XIST might alleviate the adverse function of HG on cell viability via sponging miR-497-5p, which may target FOXO1 to mediate the occurrence of GDM [ 47 ]. In contrast to the findings of Li et al., lncRNA SNX17 was dramatically upregulated in placental tissues of patients with macrosomia and may promote trophoblast proliferation through the miR-517a/IGF-1 pathway [ 48 ]. Similarly, the expression of lncRNA MALAT1 was higher in the placental tissues of the GDM patient group.…”

Section: Role Of Ncrnas In Gdmmentioning

confidence: 67%

The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes

Gao,

Ren,

Hao

et al. 2023

Briefings in Bioinformatics

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Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not have the potential to encode proteins. Meanwhile, they can occupy a significant portion of the human genome and participate in gene expression regulation through various mechanisms. Gestational diabetes mellitus (GDM) is a pathologic condition of carbohydrate intolerance that begins or is first detected during pregnancy, making it one of the most common pregnancy complications. Although the exact pathogenesis of GDM remains unclear, several recent studies have shown that ncRNAs play a crucial regulatory role in GDM. Herein, we present a comprehensive review on the multiple mechanisms of ncRNAs in GDM along with their potential role as biomarkers. In addition, we investigate the contribution of deep learning-based models in discovering disease-specific ncRNA biomarkers and elucidate the underlying mechanisms of ncRNA. This might assist community-wide efforts to obtain insights into the regulatory mechanisms of ncRNAs in disease and guide a novel approach for early diagnosis and treatment of disease.

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“…Human and in vitro placental experiments have shown that placental weight is closely related to macrosomia in GDM patients, possibly because Erk1/2 signaling is activated by hyperglycemia and promotes trophoblast cell proliferation[ 92 ]. Another study also confirmed that the macrosomia of GDM patients is associated with placental trophoblast proliferation[ 93 ]. The expression levels of miR-130b-3p, miR-29a-3p, and miR-let-7a-5p in the placenta of GDM patients decreased with increasing birth weight[ 94 ].…”

Section: Impact On the Expression Of Placental Mirnasmentioning

confidence: 71%

Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

Yi,

Wang,

et al. 2024

World J Diabetes

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Gestational diabetes mellitus (GDM) is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal development. As a bridge between the mother and the fetus, the placenta has nutrient transport functions, endocrine functions, etc. , and can regulate placental nutrient transport and fetal growth and development according to maternal metabolic status. Only by means of placental transmission can changes in maternal hyperglycemia affect the fetus. There are many reports on the placental pathophysiological changes associated with GDM, the impacts of GDM on the growth and development of offspring, and the prevalence of GDM in offspring after birth. Placental epigenetic changes in GDM are involved in the programming of fetal development and are involved in the pathogenesis of later chronic diseases. This paper summarizes the effects of changes in placental nutrient transport function and hormone secretion levels due to maternal hyperglycemia and hyperinsulinemia on the development of offspring as well as the participation of changes in placental epigenetic modifications due to maternal hyperglycemia in intrauterine fetal programming to promote a comprehensive understanding of the impacts of placental epigenetic modifications on the development of offspring from patients with GDM.

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LncRNA-SNX17 Promotes HTR-8/SVneo Proliferation and Invasion Through miR-517a/IGF-1 in the Placenta of Diabetic Macrosomia

Cited by 13 publications

References 29 publications

First Trimester Plasma MicroRNA Levels Predict Risk of Developing Gestational Diabetes Mellitus

First Trimester Plasma MicroRNA Levels Predict Risk of Developing Gestational Diabetes Mellitus

The role of ncRNA regulatory mechanisms in diseases—case on gestational diabetes

Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

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