LncRNA00978 contributes to growth and metastasis of hepatocellular carcinoma cells via mediating microRNA-125b-5p/SOX12 pathway

Cheng, Zhiqing; Gong, Limei; Qinghe, Cai

doi:10.1080/21655979.2022.2063648

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Furthermore, LINC00978 silencing could inhibit the development and metastasis of HCC cells. It was discovered that LINC00978 could sponge microRNA-125b-5p and that SOX12 (SRY-Box Transcription Factor 12) was one of its direct target genes (Cheng et al, 2022). In fact, LINC00978 has been recommended as a fundamental player in HCC diagnosis, prognosis, and future therapeutic options/targets.…”

Section: Lncrnas Involved In Hcc Diagnosis and Prognosismentioning

confidence: 99%

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

El-Aziz

Dawoud

Kiriacos

et al. 2023

Journal Cellular Physiology

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Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular carcinoma (HCC) has gained a lot of interest. Yet, underlying mechanistic basis of the liver tumorigenesis is poorly understood. The role of some coding genes and their respective translated proteins, then later on, some noncoding RNAs (ncRNAs) such as microRNAs have been extensively studied in context of HCC pathophysiology; however, the implication of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in HCC is indeed less investigated. As a subclass of the ncRNAs which has been elusive for long time ago, lncRNAs was found to be involved in plentiful cellular functions such as DNA, RNA, and proteins regulation. Hence, it is undisputed that lncRNAs dysregulation profoundly contributes to HCC via diverse etiologies. Accordingly, lncRNAs represent a hot research topic that requires prime focus in HCC. In this review, the authors discuss breakthrough discoveries involving lncRNAs and circRNAs dysregulation that have contributed to the contemporary concepts of HCC pathophysiology and how these concepts could be leveraged as potential novel diagnostic and prognostic HCC biomarkers. Further, this review article sheds light on future trends, thereby discussing the pathological roles of lncRNAs and circRNAs in HCC proliferation, migration, and epithelial‐to‐mesenchymal transition. Along this line of reasoning, future recommendations of how these targets could be exploited to achieve effective HCC‐related drug development is highlighted.

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Section: Lncrnas Involved In Hcc Diagnosis and Prognosismentioning

confidence: 99%

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

El-Aziz

Dawoud

Kiriacos

et al. 2023

Journal Cellular Physiology

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“…Studies suggest that MIR4435-2HG exhibits a significant increase in hepatocellular carcinoma tissues compared to adjacent normal tissues and shows a positive correlation with tumor size, metastasis, and unfavorable prognosis, and can be used as a prognostic biomarker [64]. Additionally, studies have found that silencing MIR4435-2HG inhibits the migration ability and EMT process induced by hepatic stellate cells in hepatocellular carcinoma cells [14,27,28]. Transcriptomics analysis revealed a substantial increase in the relative expression of MIR4435-2HG in hepatocellular carcinoma cohorts when compared to non-hepatocellular carcinoma and healthy control cohorts.…”

Section: Mir4435-2hg and Hepatocellular Carcinomamentioning

confidence: 99%

“…Current research shows that MIR4435-2HG can sequester miR-138-5p, upregulating SOX4, thereby promoting the growth, migration, and EMT process of gastric cancer cells [26]. In hepatocellular carcinoma, MIR4435-2HG sequesters miR-1-3p, miR-125b-5p, miR-22-3p, miR-513a-5p and miR-136-5p, upregulating downstream target genes such as MM9, SRY-Box transcription factor 12 (SOX12), Ribonucleotide reductase M1/2 subunit (RRM1/2), Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), Kruppel like factor 5 (KLF5), and B3GNT, thereby promoting hepatocellular carcinoma progression [13,27,28,52,[104][105][106][107]. Additionally, MIR4435-2HG is associated with the upregulation of specific miRNAs, such as the promotion of hepatocellular carcinoma cell proliferation through the upregulation of miRNA-487a [14].…”

Section: Competitive Endogenous Rnasmentioning

confidence: 99%

Biological Roles and Pathogenic Mechanisms of LncRNA MIR4435-2HG in Cancer: A Comprehensive Review

Chen,

Guan,

Zhu

et al. 2023

CIMB

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The long non-coding RNA MIR4435-2HG has been confirmed to play a crucial regulatory role in various types of tumors. As a novel type of non-coding RNA, MIR4435-2HG plays a key role in regulating the expression of tumor-related genes, interfering with cellular signaling pathways, and affecting tumor immune evasion. Its unique structure allows it to regulate the expression of various tumor-related genes through different pathways, participating in the regulation of tumor signaling pathways, such as regulating the expression of oncogenes and tumor suppressor genes, influencing the biological behaviors of proliferation, metastasis, and apoptosis in tumors. Numerous studies have found a high expression of MIR4435-2HG in various tumor tissues, closely related to the clinical pathological characteristics of tumors, such as staging, lymph node metastasis and prognosis. Some studies have discovered that MIR4435-2HG can regulate the sensitivity of tumor cells to chemotherapy drugs, affecting tumor cell drug resistance. This provides new insights into overcoming tumor drug resistance by regulating MIR4435-2HG. Therefore, studying its molecular mechanisms, expression regulation, and its relationship with the clinical features of tumors is of great significance for revealing the mechanisms of tumor occurrence and developing new therapeutic targets.

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“…Individuals with HCC have shown aberrant miRNA levels in multiple studies. Because of their robust presence in body tissues and fluids and easy detectability [16], miRNA expression is not only used as a biomarker for diagnosis and metastasis but also predicts therapeutic response, recurrence, and overall HCC survival rate [17][18][19][20]. Research has proven that METTL1 can regulate microRNAs in an m 7 G-dependent pattern.…”

Section: Introductionmentioning

confidence: 99%

N7-methylguanosine-related miRNAs predict hepatocellular carcinoma prognosis and immune therapy

Ma,

Deng

et al. 2023

Aging

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N7-methylguanosine (m 7 G) modification has been notably linked with the development of many tumors. However, no investigations have been conducted on whether m 7 G-related miRNA (m 7 G-miRNA) is a prognostic index of hepatocellular carcinoma (HCC). Therefore, this investigation aimed to establish a predictive m 7 G-miRNA signature for efficient HCC prognosis and elucidate the associated immune cell infiltration (ICI) and functions in the tumor microenvironment. RNA sequencing and clinical data on 375 HCC and 50 healthy tissue samples were acquired from The Cancer Genome Atlas database. The m 7 G-miRNA regulators methyltransferase-like 1 and WD repeat domain 4 were acquired from the TargetScan database. Univariate Cox regression analysis was conducted on the 63 differentially expressed m 7 G-miRNAs identified. A prognostic signature that consisted of seven miRNAs was identified. According to their risk scores, individuals with HCC were divided into high-risk (HR) and low-risk (LR) cohorts. A Kaplan-Meier test revealed that survival in the HR HCC patients was poorer than in the LR cohort (p < 0.001). The area under the receiver operating characteristic curves of 1-, 3-, and 5-year overall survival were 0.706, 0.695, and 0.715, respectively. A nomogram of sex, risk score, age, and stage indicated the HCC patients’ overall survival. Furthermore, it was indicated that the HR and LR patients had different degrees of ICI and immune function. A pathway enrichment analysis revealed the association of several immunity-linked pathways with the risk model. In conclusion, the signature established has great prognostic value and could be used as a new immunotherapy target for individuals with HCC.

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LncRNA00978 contributes to growth and metastasis of hepatocellular carcinoma cells via mediating microRNA-125b-5p/SOX12 pathway

Cited by 4 publications

References 33 publications

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

Biological Roles and Pathogenic Mechanisms of LncRNA MIR4435-2HG in Cancer: A Comprehensive Review

N7-methylguanosine-related miRNAs predict hepatocellular carcinoma prognosis and immune therapy

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