LncRNAs and cancer

Zhang, Rui; Li, Xia; Lu, Wen; Zhang, Jing; Zhu, Jingde

doi:10.3892/ol.2016.4770

Cited by 97 publications

(74 citation statements)

References 62 publications

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“…Long non-coding RNAs (lncRNAs) are a kind of non-coding RNAs that transcripts longer than 200 nucleotides, with no protein-coding function [5,6]. LncRNAs play important roles in many processes of cellular functions, for instance, X chromosome imprinting, chromatin modification, and immune response [7,8].…”

Section: Introductionmentioning

confidence: 99%

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

2019

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This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

2019

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“…Long ncRNAs are heterogenous group of RNAs, more than 200 nucleotides long and recently shown to be involved in many biological processes. Their numbers are significantly higher than the protein‐coding genes, can act in cis and/or in trans, and are involved in disease or developmental stage including human cancers (Djebali et al., ; Zhang, Xia, Lu, Zhang, & Zhu, ). LncRNAs regulate many biological functions like imprinting genomic loci and regulating chromosome conformation (Quinn & Chang, ).…”

Section: Introductionmentioning

confidence: 99%

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

et al. 2017

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides) responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor suppressor miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and have been also implicated in carcinogenesis. These molecules have been suggested to be promising candidates as diagnostic and prognostic biomarkers and for development of novel therapeutic approaches. In this review, we have summarized recent findings on role of these ncRNAs in HPV-negative (HPV-ve) and HPV-positive (HPV+ve) HNSCC. The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs.

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“…Long non‐coding RNAs (lncRNA), commonly defined as non‐coding transcripts >200 nucleotides in length, have emerged as a class of key regulatory RNAs. LncRNAs are deregulated in diverse human cancers and associated with disease progression (Yarmishyn & Kurochkin, ; Schmitt & Chang, ; Zhang et al , ). Aberrant expression of lncRNA contributes to human carcinogenesis, metastasis, stem cell differentiation and resistance to chemotherapy; in addition, lncRNA may play a role in MM progression, but supporting data are limited (Zhou et al , ).…”

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confidence: 99%

Long non‐coding RNA MALAT1 is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma

et al. 2017

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Extramedullary myeloma (EMM) occurs when myeloma develops outside the bone marrow; it often develops after chemotherapy and is associated with the acquisition of chemo-resistance and a fatal course. The mechanisms underlying extramedullary spread have not yet been fully elucidated. MALAT1 is a highly abundantly and ubiquitously expressed long non-coding RNA that plays important roles in cancer metastasis. The aims of this study were to clarify the association of MALAT1 with EMM and to elucidate the underlying mechanism of EMM formation under chemotherapeutic pressure. MALAT1 expression was significantly higher in multiple myeloma (MM) than in monoclonal gammopathy of undetermined significance. Furthermore, MALAT1 expression was markedly higher in EMM compared with that in corresponding intramedullary myeloma cells. A higher MALAT1 level was associated with shorter overall and progression-free survival. MALAT1 expression level was positively correlated with expression of HSP90AA1, HSP90AB1 and HSP90B1 but not with TP53 expression. MALAT1 was significantly upregulated by bortezomib and doxorubicin. Considering the known functions of MALAT1, our results suggest that it acts as a stress response gene that is upregulated by chemotherapy, thereby linking chemotherapy to EMM formation. Elucidating the biological implication of long non-coding RNA contributes to deeper understanding concerning the pathogenesis and investigation of novel therapeutic targets for MM.

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LncRNAs and cancer

Cited by 97 publications

References 62 publications

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

Long non‐coding RNA MALAT1 is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma

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