LncRNAs expression in adjuvant-induced arthritis rats reveals the potential role of LncRNAs contributing to rheumatoid arthritis pathogenesis

Jiang, Hui; Qin, Xiu Juan; Li, Wei Ping; Ma, Rong; Wang, Ting; Li, Zhu Qing

doi:10.1016/j.gene.2016.08.012

Cited by 23 publications

(14 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research has investigated the lncRNA expression profile in patients with rheumatoid arthritis ( 25 , 26 ), and it was concluded that lncRNA may contribute to the pathogenesis of rheumatoid arthritis ( 26 ). Compared with these studies in rheumatoid arthritis, lncRNA expression in HOA was analyzed with bioinformatics analyses, and the potential association between lncRNAs and coding genes was inferred.…”

Section: Discussionmentioning

confidence: 99%

Expression of long non-coding RNAs in chondrocytes from proximal interphalangeal joints

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Osteoarthritis (OA) of hand is a common disease, resulting in disability of the hands. The pathogenesis of hand (H) OA remains to be elucidated, and findings from knee and hip joints cannot be simply applied to HOA. To improve knowledge on the specific biology and pathobiology of HOA, the present study performed bioinformatics analyses to analyze the long non-coding (lnc) RNA expression profile in human chondrocytes of proximal interphalangeal (PIP) finger joints and knee joints. Gene expression data were downloaded from the Gene Expression Omnibus database, and PIP and knee chondrocytes were analyzed (n=3/group). Probes of the Affymetrix Human Gene 2.0 ST Microarray were annotated to obtain information about lncRNA expression profile. Compared with chondrocytes from knee joints, chondrocytes derived from PIP joints had significantly different lncRNA expression profiles, and 1,172 lncRNAs were differentially expressed. Compared with chondrocyte from knee joints, 534 lncRNAs were upregulated and 638 lncRNAs were downregulated in chondrocytes from PIP joints. A co-expression network was constructed to analyze the correlation between lncRNAs and protein-coding genes. Function annotation analyses suggested that protein-coding genes that are co-expressed with lncRNAs are enriched in the biological processes of bone morphogenesis, bone development and cartilage development. In conclusion, the present study demonstrated that chondrocytes derived from PIP joints exhibit a significant difference in lncRNA expression compared with chondrocytes derived from knee joints.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of long non-coding RNAs in chondrocytes from proximal interphalangeal joints

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…Recently, the involvement of lncRNAs in the pathogenesis of RA has attracted increasing attention. High-throughput analyses by microarray or sequencing revealed that the expression profiles of lncRNAs are altered in the PBMCs [ [50] , [51] , [52] ], serum exosomes [ 51 ], osteoclasts [ 51 ], FLSs [ 51 , 53 ], synovial tissues [ 54 ], plasma [ 55 , 56 ], and synovium of a rat model of RA [ 57 ]. Some of these differentially expressed lncRNAs are related to disease activity.…”

Section: Important Roles Of Lncrnas In Autoimmune Diseasesmentioning

confidence: 99%

“…In CD 14 (+) monocytes from RA patients, a large number of lncRNAs exhibited significantly altered expression after either IL-6 or TNF-α inhibition [ 58 ]. Aside from human lncRNAs, lncRNA expression in the synovium of rats with adjuvant-induced arthritis (AA) differs from that in the synovium of control rats [ 59 ]. In addition, treatment with astragalosides (AST), a traditional Chinese medicine used in the treatment of RA, greatly changes the expression profile of lncRNAs in an AA rat model [ 60 ].…”

Section: Important Roles Of Lncrnas In Autoimmune Diseasesmentioning

confidence: 99%

“… Autoimmune disease lncRNA Species Tissue/cell Expression level Function Ref RA Hotair, LUST, anti-NOS2A, MEG9, SNHG4, TUG1, NEAT1 Human Serum exosome Up-regulated – [ 51 ] Malat1, SNHG1, mascRNA, PR antisense transcripts, PRINS, HOXA3as Human Serum exosome Down-regulated [ 51 ] Hotair, LUST, H19 antisense, anti-NOS2A, MEG9, SNHG4, HAR1B, TUG1, NEAT1, and GAS5 Human PBMC Up-regulated [ 51 ] DHFR upstream transcripts, Jpx, KRASP1, mascRNA, PR antisense transcripts, PRINS, and HOXA3as Human PBMC Down-regulated [ 51 ] ENST00000483588 Human FLSs Up-regulated Positively correlated with CRP and the Simplified Disease Activity Index score(SDAI). [ 53 ] lnc-AL928768.3, lnc-AC091493.1 Human Synovium tissue Up-regulated Positively associated with CRP and disease activity score in 28 joints(DAS28) [ 54 ] U75927, XR_008357, MRAK046251, AA rat Synovium tissue Up-regulated [ 59 ] DQ266363, XR_006457, MRAK003448 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases

Zou

2020

Journal of Translational Autoimmunity

View full text Add to dashboard Cite

Autoimmune diseases are a group of heterogeneous disorders characterized by damage to various organs caused by abnormal innate and adaptive immune responses. The pathogenesis of autoimmune diseases is extremely complicated and has not yet been fully elucidated. Long noncoding RNAs (lncRNAs), which are defined as transcripts containing more than 200 nucleotides with no protein-coding capacity, are emerging as important regulators of gene expression via epigenetic modification, transcriptional regulation and posttranscriptional regulation. Accumulating evidence has demonstrated that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. In this review, we discuss various molecular mechanisms by which lncRNAs regulate gene expression and recent findings regarding the involvement of lncRNAs in many human autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), systemic sclerosis (SSc) and Sjögren’s syndrome (pSS).

show abstract

“…compared the expression of lncRNAs in FLSs between the RA model rats induced by Freund’s complete adjuvant (FCA) and HCs. [23] Up to 260 lncRNAs were found to be dysregulated in FCA-induced RA model rats. Of those, six dysregulated lncRNAs including XR_008357, U75927, MRAK046251, XR_006457, DQ266363 and MRAK003448 were further validated by qRT-PCR.…”

Section: Dysregulated Expression Of Lncrnas In Ramentioning

confidence: 99%

LncRNA: An all-rounder in rheumatoid arthritis

Liang

Chen

Lin

2019

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA.

show abstract

LncRNAs expression in adjuvant-induced arthritis rats reveals the potential role of LncRNAs contributing to rheumatoid arthritis pathogenesis

Cited by 23 publications

References 44 publications

Expression of long non-coding RNAs in chondrocytes from proximal interphalangeal joints

Expression of long non-coding RNAs in chondrocytes from proximal interphalangeal joints

Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases

LncRNA: An all-rounder in rheumatoid arthritis

Contact Info

Product

Resources

About