LncRNAs in Kawasaki disease and Henoch-Schönlein purpura: mechanisms and clinical applications

Yang, Kangping; Tang, Jiayao; Li, Haoying; Zhang, Hejin; Ding, Jiatong; Li, Zelin; Luo, Jinghua

doi:10.1007/s11010-023-04832-x

Mol Cell Biochem

2023

DOI: 10.1007/s11010-023-04832-x

|View full text |Cite

LncRNAs in Kawasaki disease and Henoch-Schönlein purpura: mechanisms and clinical applications

Kangping Yang,

Jiayao Tang,

Haoying Li

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study

Espinosa-Bautista,

Salazar-Sánchez,

Brianza-Padilla

et al. 2024

Clin Rheumatol

View full text Add to dashboard Cite

Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study

Espinosa-Bautista,

Salazar-Sánchez,

Brianza-Padilla

et al. 2024

Clin Rheumatol

View full text Add to dashboard Cite

Non-coding RNAs as potential targets in metformin therapy for cancer

Zhang,

Wu,

Liu

et al. 2024

Cancer Cell Int

View full text Add to dashboard Cite

Metformin, a widely used oral hypoglycemic drug, has emerged as a potential therapeutic agent for cancer treatment. While initially known for its role in managing diabetes, accumulating evidence suggests that metformin exhibits anticancer properties through various mechanisms. Several cellular or animal experiments have attempted to elucidate the role of non-coding RNA molecules, including microRNAs and long non-coding RNAs, in mediating the anticancer effects of metformin. The present review summarized the current understanding of the mechanisms by which non-coding RNAs modulate the response to metformin in cancer cells. The regulatory roles of non-coding RNAs, particularly miRNAs, in key cellular processes such as cell proliferation, cell death, angiogenesis, metabolism and epigenetics, and how metformin affects these processes are discussed. This review also highlights the role of lncRNAs in cancer types such as lung adenocarcinoma, breast cancer, and renal cancer, and points out the need for further exploration of the mechanisms by which metformin regulates lncRNAs. In addition, the present review explores the potential advantages of metformin-based therapies over direct delivery of ncRNAs, and this review highlights the mechanisms of non-coding RNA regulation when metformin is combined with other therapies. Overall, the present review provides insights into the molecular mechanisms underlying the anticancer effects of metformin mediated by non-coding RNAs, offering novel opportunities for the development of personalized treatment strategies in cancer patients.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

LncRNAs in Kawasaki disease and Henoch-Schönlein purpura: mechanisms and clinical applications

Cited by 2 publications

References 137 publications

Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study

Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study

Non-coding RNAs as potential targets in metformin therapy for cancer

Contact Info

Product

Resources

About