lnterleukin-6 Production by Draining Lymph Node Cells following Primary Contact Sensitisation of Mice: Relationship to the Proliferative Response

Hope, Jayne; Dearman, R.J.; Debicki, R.J.; Kimber, Ian; Hopkins, Stephen

doi:10.1159/000236657

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…The latter accords with our observation that proliferation and IL-6 production by LNCs are highly correlated (Hope, Dearman, Debicki, et al, 1994). Initially, we determined the proliferation of draining LNCs in response to application of antigens to the skin of Syrian hamsters.…”

Section: Discussionsupporting

confidence: 83%

Different Photoperiods Affect Proliferation of Lymphocytes but Not Expression of Cellular, Humoral, or Innate Immunity in Hamsters

Zhou¹,

Cagampang²,

Stirland³

et al. 2002

J Biol Rhythms

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In seasonal mammals, photoperiod change is associated with a suite of alterations in physiology. It has recently been proposed that the immune response is one of the systems regulated by changes in photoperiod, although this hypothesis has not been rigorously challenged by assays of functional immune responses. The aim of this study was to test the hypothesis that photoperiod modulates immune responsiveness in Syrian (Mesocricetus auratus) and Siberian (Phodopus sungorus) hamsters. Consistent with previously reported data, short-day-housed (SD) animals exhibited a significant increase in lymph node cell (LNC) numbers and increased cellular proliferation in response to the polyclonal mitogen concanavalin A compared to long-day-housed (LD) animals. In contrast, LNC numbers from intact or gonadectomized SD animals that had been sensitized with the antigen dinitrofluorobenzene (DNFB) exhibited a reduced ex vivo proliferative response and reduced production of interleukin-6 (IL-6) compared to LD animals. In vivo studies of the contact hypersensitivity response of animals that had previously been sensitized, and subsequently challenged, with DNFB were similar in SD and LD animals, as was the proliferative activity of LNC recovered from these animals. There were also no photoperiodic differences in the antidinitrophenyl antibody response of animals sensitized with DNFB, or the anti-sheep red blood cell (srbc) response of animals immunized with srbc. Furthermore, no differences could be detected in the activity of natural killer cells from spleens of LD and SD Siberian hamsters, or in lipopolysaccharide-induced IL-6 production by LD and SD Syrian hamsters in vivo. Thus, although photoperiod is able to influence factors regulating the gross number and non-antigen-specific proliferation of lymphocytes in seasonally breeding mammals, day length does not directly influence activation of an effective immune response. The authors conclude, therefore, that expression of the immune response is not directly modified or compromised by photoperiod in these seasonally breeding hamster species.

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Section: Discussionsupporting

confidence: 83%

Different Photoperiods Affect Proliferation of Lymphocytes but Not Expression of Cellular, Humoral, or Innate Immunity in Hamsters

Zhou¹,

Cagampang²,

Stirland³

et al. 2002

J Biol Rhythms

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“…In line with data from local lymph node assays in mice (Hope et al 1994b) and rats (Arts et al 1996), an increase in DLN cell numbers and ex vivo proliferation, the immunological correlates of hapten's contact-sensitizing potential, was noted in rats sensitized with DNCB. Higher DLN cellularity in sensitized, as compared to non-sensitized rats might be a consequence of cell migration to lymph nodes and/or cell proliferation.…”

Section: Discussionsupporting

confidence: 72%

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

et al. 2011

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“…Recently, some investigators have reported that retinoids modulate the production of cytokines such as IL-6 [5], IL-4 [6] and IFN-Á [7] at the transcriptional level. Retinoid is a potent ligand for retinoic acid receptors (RARs), which belong to the steroid/thyroid receptor superfamily [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Am-80, a Retinoid Derivative, on 2,4-Dinitrofluorobenzene-Induced Contact Dermatitis in Mice

et al. 2000

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Retinoids have many pharmacological activities, including anti-inflammatory action and antiangiogenesis, effected through the regulation of various gene transcriptions. In this study, we investigated the effect of Am-80, one of the retinoic acid derivatives, on hapten-induced contact hypersensitivity in BALB/c mice. After application of 2,4-dinitrofluorobenzene (DNFB) to the ears of the mice, severe contact hypersensitivity with marked infiltration of inflammatory cells and hypertrophy of the epidermis was caused. The thickness of the ears increased biphasically and reached a peak 3 and 24 h after the DNFB challenge. Am-80 significantly inhibited ear thickness in the late-(24 h), but not the early-phase (3 h) reaction in a dose-dependent manner. In a histopathological study, obvious depression of edema and infiltration of inflammatory cells was observed in the ears of mice treated with Am-80. Am-80 inhibited the levels of expression in mice ears of interferon-γ (IFN-γ) and interleukin-6 (IL-6), but not tumor necrosis factor-α (TNF-α) or interleukin-4 (IL-4). Furthermore, Am-80 inhibited the antigen-induced production of some cytokines, including IFN-γ and IL-6, but not IL-4, in vitro. Therefore, Am-80 inhibited hapten-induced contact hypersensitivity through the direct inhibition of inflammatory cytokines such as IFN-γ and IL-6.

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lnterleukin-6 Production by Draining Lymph Node Cells following Primary Contact Sensitisation of Mice: Relationship to the Proliferative Response

Cited by 20 publications

References 16 publications

Different Photoperiods Affect Proliferation of Lymphocytes but Not Expression of Cellular, Humoral, or Innate Immunity in Hamsters

Different Photoperiods Affect Proliferation of Lymphocytes but Not Expression of Cellular, Humoral, or Innate Immunity in Hamsters

Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase

Effect of Am-80, a Retinoid Derivative, on 2,4-Dinitrofluorobenzene-Induced Contact Dermatitis in Mice

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