Load‐bearing biodegradable polycaprolactone‐poly (lactic‐co‐glycolic acid)‐ beta tri‐calcium phosphate scaffolds for bone tissue regeneration

Kumar, Alok; Zhang, Yiren; Terracciano, Amalia; Zhao, Xiao Ling; Su, Tsan‐Liang; Kalyon, Dilhan M.; Katebifar, Sara; Kumbar, Sangamesh G.; Yu, Xiaojun

doi:10.1002/pat.4551

Cited by 17 publications

(5 citation statements)

References 46 publications

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“…Kim et al fabricated magnesium phosphate ceramic 3D scaffolds and observed that, at 6 weeks after implantation, the primary structure of the scaffold was broken, while the scaffold residual remained thick. In another study, Kumar et al 39 fabricated load-bearing PCL/poly (lactic-co-glycolic acid) (PLGA)-beta tri-calcium phosphate scaffolds. They observed that the increasing the PLGA concentration accelerated the degradation rate.…”

Section: Resultsmentioning

confidence: 99%

Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study

Samadian

Khastar

Ehterami

et al. 2021

Sci Rep

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The main aim of the present study was to fabricate 3D scaffold based on poly (l-lactic acid) (PLLA)/Polycaprolactone (PCL) matrix polymer containing gelatin nanofibers (GNFs) and gold nanoparticles (AuNPs) as the scaffold for bone tissue engineering application. AuNPs were synthesized via the Turkevich method as the osteogenic factor. GNFs were fabricated by the electrospinning methods and implemented into the scaffold as the extracellular matrix mimicry structure. The prepared AuNPs and Gel nanofibers were composited by PLLA/PCL matrix polymer and converted to a 3D scaffold using thermal-induced phase separation. SEM imaging illustrated the scaffold's porous structure with a porosity range of 80–90% and a pore size range of 80 to 130 µm. The in vitro studies showed that the highest concentration of AuNPs (160 ppm) induced toxicity and 80 ppm AuNPs exhibited the highest cell proliferation. The in vivo studies showed that PCL/PLLA/Gel/80ppmAuNPs induced the highest neo-bone formation, osteocyte in lacuna woven bone formation, and angiogenesis in the defect site. In conclusion, this study showed that the prepared scaffold exhibited suitable properties for bone tissue engineering in terms of porosity, pore size, mechanical properties, biocompatibility, and osteoconduction activities.

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Section: Resultsmentioning

confidence: 99%

Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study

Samadian

Khastar

Ehterami

et al. 2021

Sci Rep

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“…PLGA includes: (1) The production of acidic substances in the degradation process leads to a decrease in local pH, which may cause inflammation of the tissue surrounding the implant [25] . (2) Brittle materials with low mechanical strength [26] …”

Section: Introductionmentioning

confidence: 99%

Performance of 3D printed PCL/PLGA/HA biological bone tissue engineering scaffold

Wang

Xie

et al. 2021

Polymer Composites

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In the repair of bone defects, bone tissue engineering scaffolds made of degradable polymers are considered as potential bone defect graft substitutes. Among them, polycaprolactone (PCL) and polylactic acid coglycolic acid (PLGA) are widely used in tissue engineering. PCL has good processability. However, the poor hydrophilicity of PCL leads to a lower cell adhesion rate of pure PCL scaffolds. PLGA has good biological properties. However, the production of acidic substances during the rapid degradation of PLGA will result in low‐local pH, and PLGA has poor toughness. In this study, PCL and PLGA were mixed in different proportions and 20 wt% hydroxyapatite (HA) was added. A PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The regular grid structure makes the transportation of nutrients more convenient. The PCL component in the scaffold improves the toughness of the scaffold. Due to the mixing of PLGA, the hydrophilicity of the composite scaffold is improved, making the scaffold more conducive to cell adhesion. At the same time, the HA component contained in the composite scaffold provides Ca2+ and PO43− for the scaffold, which promotes the osteogenic differentiation of cells on the composite scaffold. Since the PCL/PLGA/HA composite scaffold prepared by 3D printing has shown good performance in mechanical and cell tests, we believe that the composite scaffold has potential applications in the field of bone tissue engineering.

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“…CuNPs preparadas a partir do ácido ascórbico apresentaram uma área superficial (SBET) de 8m² g -1 , e volume de poros (Vp) de 0,040 cm³ g -1 , diâmetro de poros (Dp) de 20,53 nm, indicando um comportamento mesoporoso (2 < Dp < 50 nm) (KUMAR et al, 2019). )…”

Section: Resultados E Discussõesunclassified

Biosíntese E Caracterização De Nanopartículas De Cobre Para a Aplicação Em Engenharia De Tecidos

PINHEIRO¹,

MACHADO²,

SILVA³

2022

Anais Do Simpósio De Ensino, Pesquisa E Extensão (SEPE 2022)

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As lesões por pressões ocorrem em pacientes acamados, causando riscos adicionais ao paciente, como graves infecções. A nanotecnologia, aliada com a engenharia tecidual, surgem como alternativa para a busca de soluções inovadoras, por meio da aplicação de nanopartículas metálicas para auxílio dessa problemática. Nesse contexto, este trabalho tem o objetivo sintetizar e caracterizar nanopartículas de cobre (CuNPs) pelo método de biossíntese a partir ácido ascórbico, para possível aplicação em curativos cicatrizantes. CuNPs foram caracterizadas pelas técnicas de difração de raios X (DRX), microscopia eletrônica de alta resolução (MEV-FEG) e adsorção/dessorção de N2 (método BET/BJH). O difratograma mostrou picos característicos das CuNPs com uma estrutura cúbica de face centrada representando cobre metálico. A micrografia das CuNPs mostrou aglomerados heterogêneos devido à biossíntese, com área superficial de 8 m² g -1 e volume de poros de 0,04 cm³ g -1 . O perfil de segurança será realizado para verificar a avaliação na engenharia de tecidos.

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Load‐bearing biodegradable polycaprolactone‐poly (lactic‐co‐glycolic acid)‐ beta tri‐calcium phosphate scaffolds for bone tissue regeneration

Cited by 17 publications

References 46 publications

Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study

Bioengineered 3D nanocomposite based on gold nanoparticles and gelatin nanofibers for bone regeneration: in vitro and in vivo study

Performance of 3D printed PCL/PLGA/HA biological bone tissue engineering scaffold

Biosíntese E Caracterização De Nanopartículas De Cobre Para a Aplicação Em Engenharia De Tecidos

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