The power flows in the unified power flow controller (UPFC) embedded system is mainly regulated by the two variables containing the magnitude and the phase angle of the output series inserted voltage (OSIV) of UPFC. Different value combinations of the two variables can form multiple regulation modes of OSIV, and the regulation principles and efficiencies for power flows are distinct by different regulation modes. This paper dedicates to research the regulation principles of active and reactive power flow gradients (PFG) to multiple characteristic independent variables (CIVs) at several selected critical points (SCP) of the system in different operation conditions. The CIVs contains the magnitude of OSIV, the phase angle of OSIV, and the phase difference of the system. First, multiple power flow regulation modes of OSIV are designed, the mathematical models of the PFG to each CIV at each SCP are established, and the theoretical principles for the PFG to each CIV at each SCP are analyzed and compared. Next, four typical operation conditions of the system and four regulation scenarios are assumed and case studies for the PFG to each CIV at different SCP are carried out. The test results at each SCP are analyzed both in the two-dimensional planes and three-dimensional spaces. The regulation principles and efficiencies of PFG to each CIV at different SCP are compared with each other and summarized, which can offer useful references for practical engineering and applications of UPFC.