The construction of strut‐and‐tie models (STMs) is the key, but also the difficulty when the model is used to describe the force mechanism and guide the reinforcement layout design of concrete disturbed regions (D‐regions). Topology optimization is a promising way to guide STMs construction. Different from the existing construction methods of predetermining nodes, the angle of inclination of the truss elements is first determined to ensure that it is consistent with that of the principal stresses in a 2D finite element model of the structure. The constructed model can well reflect the force transmission path of structural members, and it is better than the existing methods when it is evaluated through the principle of minimum strain energy. To verify the validity of the STM, a reinforcement layout scheme is adopted completely according to the position of the tension ties. On this basis, another reinforcement layout scheme adds additional transverse reinforcements in the bottle‐shaped stress field. The nonlinear finite element comparative analysis of an irregular deep beam designed by the two schemes is carried out. The results show that the two ultimate loads are close. Brittle failure occurs in the former, while the latter has higher deformability and eventually ductile failure occurs.